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| Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
20/12/2011 |
Data da última atualização: |
05/02/2024 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
BRUGIOLO, A. S. S.; ALVES, C. C. de S.; GOUVEIA, A. C. C.; DIAS, A. T.; RODRIGUES, M. F.; PACÍFICO, L. G. G.; AARESTRUP, B. J. V.; MACHADO, M. A.; DOMINGUES, R.; TEIXEIRA, H. C.; GAMEIRO, J.; FERREIRA, A. P. |
Afiliação: |
ALESSA SIN SINGER BRUGIOLO, UFJF; CAIO CÉSAR DE SOUZA ALVES, UFJF; ANA CLÁUDIA CARVALHO GOUVEIA, UFJF; ALYRIA TEIXEIRA DIAS, UFJF; MICHELE FERNANDES RODRIGUES, UFJF; LUCILA GROSSI GONÇALVES PACÍFICO, FIOCRUZ; BEATRIZ JULIÃO VIEIRA AARESTRUP, UFJF; MARCO ANTONIO MACHADO, CNPGL; ROBERT DOMINGUES, UFJF; HENRIQUE COUTO TEIXEIRA, UFJF; JACY GAMEIRO, UFJF; ANA PAULA FERREIRA, UFJF. |
Título: |
Effects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy. |
Ano de publicação: |
2011 |
Fonte/Imprenta: |
Annals of Allergy, Asthma & Immunology, v. 106, n. 6, p. 481-488, 2011. |
DOI: |
https://doi.org/10.1016/j.anai.2011.01.008 |
Idioma: |
Inglês |
Conteúdo: |
Background - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and may be useful as a potential therapeutic agent for asthma. MenosBackground - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and ma... Mostrar Tudo |
Palavras-Chave: |
Allergic pulmonary inflammation. |
Thesaurus Nal: |
Asthma; Immune response. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 02517naa a2200301 a 4500 001 1910453 005 2024-02-05 008 2011 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.anai.2011.01.008$2DOI 100 1 $aBRUGIOLO, A. S. S. 245 $aEffects of aqueous extract of Echinodorus grandiflorus on the immune response in ovalbumin-induced pulmonary allergy.$h[electronic resource] 260 $c2011 520 $aBackground - Asthma is a disease characterized by intermittent obstruction of the airways and chronic inflammation that affects approximately 300 million people worldwide. The immune response in asthma is predominantly TH2, with high levels of total and allergen-specific IgE and bronchial eosinophilia. Asthma treatment is aimed at controlling the disease, and the drugs used currently have systemic adverse effects and generally are not effective in difficult-to-control cases. Objective - To investigate the effect of aqueous extract of Echinodorus grandiflorus, a plant used in folk medicine for its diuretic and anti-inflammatory properties, in a model of pulmonary allergy. Methods - BALB/c mice were intraperitoneally sensitized and nasally challenged with ovalbumin. Aqueous extract and dexamethasone treatments (0.1 mL/d per mouse) were initiated on day 32 and concluded on day 40. Eight hours after the last challenge evaluations, of serum, bronchoalveolar lavage, and lung tissue were performed. Results - Oral treatment with the extract markedly reduced the number of total cells and eosinophils in bronchoalveolar lavage. The eosinophil peroxidase activity in lung tissue, the levels of ovalbumin-specific IgE in serum, the levels of CCL11, and the gene expression of interleukin 4 and interleukin 13 in lung tissue were also lower after treatment. Conclusions - These results suggest that the aqueous extract of E grandiflorus is able to modulate allergic pulmonary inflammation and may be useful as a potential therapeutic agent for asthma. 650 $aAsthma 650 $aImmune response 653 $aAllergic pulmonary inflammation 700 1 $aALVES, C. C. de S. 700 1 $aGOUVEIA, A. C. C. 700 1 $aDIAS, A. T. 700 1 $aRODRIGUES, M. F. 700 1 $aPACÍFICO, L. G. G. 700 1 $aAARESTRUP, B. J. V. 700 1 $aMACHADO, M. A. 700 1 $aDOMINGUES, R. 700 1 $aTEIXEIRA, H. C. 700 1 $aGAMEIRO, J. 700 1 $aFERREIRA, A. P. 773 $tAnnals of Allergy, Asthma & Immunology$gv. 106, n. 6, p. 481-488, 2011.
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| Acesso ao texto completo restrito à biblioteca da Embrapa Agroenergia. Para informações adicionais entre em contato com cnpae.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Agroenergia. |
Data corrente: |
17/10/2012 |
Data da última atualização: |
19/09/2013 |
Tipo da produção científica: |
Artigo em Anais de Congresso |
Autoria: |
FRANCO, P. F.; LIMA, L. M.; POLETTO, C. M.; MENDES, T. D.; SALUM, T. F. C.; FAVARO, L. C. de L.; ALMEIDA, J. R. M. de. |
Afiliação: |
PAULA FERNANDES FRANCO, CNPAE; Larissa M. Lima; CAROLINA MADALOZZO POLETTO, CNPAE; THAIS DEMARCHI MENDES, CNPAE; THAIS FABIANA CHAN SALUM, CNPAE; LEIA CECILIA DE LIMA FAVARO, CNPAE; JOAO RICARDO MOREIRA DE ALMEIDA, CNPAE. |
Título: |
Prospecção e melhoramento de microrganismos para produção de etanol lignocelulósico. |
Ano de publicação: |
2012 |
Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 2., 2012, Belém, PA. Anais... Brasília, DF: SBRG; Manaus: Embrapa Amazônia Ocidental, 2012. |
Páginas: |
Não paginado. |
Idioma: |
Português |
Palavras-Chave: |
Biocombustíveis; Glicerol bruto; Leveduras; Lignocelulose. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00785nam a2200229 a 4500 001 1936972 005 2013-09-19 008 2012 bl uuuu u00u1 u #d 100 1 $aFRANCO, P. F. 245 $aProspecção e melhoramento de microrganismos para produção de etanol lignocelulósico.$h[electronic resource] 260 $aIn: CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 2., 2012, Belém, PA. Anais... Brasília, DF: SBRG; Manaus: Embrapa Amazônia Ocidental$c2012 300 $aNão paginado. 653 $aBiocombustíveis 653 $aGlicerol bruto 653 $aLeveduras 653 $aLignocelulose 700 1 $aLIMA, L. M. 700 1 $aPOLETTO, C. M. 700 1 $aMENDES, T. D. 700 1 $aSALUM, T. F. C. 700 1 $aFAVARO, L. C. de L. 700 1 $aALMEIDA, J. R. M. de
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