Enzymatic Basis Of Phase I And Phase II Drug Metabolism -- Transporters: Importance In Drug Absorption, Distribution And Elimination -- ADME Pharmacogenetics and Its Impact on Drug-Drug Interactions -- Impact Of Nuclear Receptors, CAR, PXR, FXR, And VDR, And Their Ligands On Enzymes And Transporters -- Impact of Physiological Determinants: Flow, Binding, Transporters And Enzymes On Organ and Total Body Clearances -- In Silico Approaches to Predict Drug-Drug Interactions -- In Vitro Techniques To Study Drug-Drug Interactions Of Drug Metabolism: Cytochrome P450 -- In Vitro Characterization Of Inhibitory Drug-Drug Interactions Involving UDP-Glucuronosyltransferase -- In Vitro Techniques To Study Transporter-Based Drug-Drug Interactions -- In Vitro Techniques To Study Drug-Drug Interactions Involving Transport: Caco-2 Model For Study Of P-Glycoprotein And Other Transporters -- Use Of In Vivo Animal Models To Assess Drug-Drug Interactions -- Extrapolation of In Vitro Metabolic and P-Glycoprotein-mediated Transport Data To In Vivo By Modeling and Simulations -- Translation Of In Vitro Metabolic Data To Predict In Vivo Drug-Drug Interactions: IVIVE And Modeling And Simulations -- Absorption Models To Examine Bioavailability And DDI’s In Humans -- Management Of Drug Interactions Of New Drugs In Multicenter Trials Using The Metabolism & Transport Drug Interaction Database© -- Web-Based Database As A Tool To Examine Drug-Drug Interactions Involving Transporters -- Drug Disposition And Drug-Drug Interactions: Importance Of First-Pass Metabolism In Gut And Liver -- Transporter Based Drug-Drug Interactions And Their Effect On Distribution Volumes -- Inactivation Of Human Cytochrome P450 Enzymes And Drug-Drug Interactions -- Allosteric Enzyme And Transporter Based Interactions -- Interplay Of Transporter-Drug Interaction: Complications Of Both Inhibitory And Inductive Events In Drug-Drug Interaction -- Herbal Supplement-Based Interactions -- Anticipating And Minimizing Drug Interactions In A Drug Discovery And Development Setting: Industrial Perspective -- Clinical Studies Of Drug-Drug Interactions: Design And Interpretation -- Toxicological Consequences Of Drug-Drug Interactions -- Complex Drug Interactions: Significance And Evaluation -- DDI: Labeling And Marketing Perspectives -- Drug-Drug Interactions: What Have We Learnt And Where Are We Going?

Enzymatic Basis Of Phase I And Phase II Drug Metabolism -- Transporters: Importance In Drug Absorption, Distribution And Elimination -- ADME Pharmacogenetics and Its Impact on Drug-Drug Interactions -- Impact Of Nuclear Receptors, CAR, PXR, FXR, And VDR, And Their Ligands On Enzymes And Transporters -- Impact of Physiological Determinants: Flow, Binding, Transporters And Enzymes On Organ and Total Body Clearances -- In Silico Approaches to Predict Drug-Drug Interactions -- In Vitro Techniques To Study Drug-Drug Interactions Of Drug Metabolism: Cytochrome P450 -- In Vitro Characterization Of Inhibitory Drug-Drug Interactions Involving UDP-Glucuronosyltransferase -- In Vitro Techniques To Study Transporter-Based Drug-Drug Interactions -- In Vitro Techniques To Study Drug-Drug Interactions Involving Transport: Caco-2 Model For Study Of P-Glycoprotein And Other Transporters -- Use Of In Vivo Animal Models To Assess Drug-Drug Interactions -- Extrapolation of In Vitro Metabolic and P-Glycoprotein-mediated Transport Data To In Vivo By Modeling and Simulations -- Translation Of In Vitro Metabolic Data To Predict In Vivo Drug-Drug Interactions: IVIVE And Modeling And Simulations -- Absorption Models To Examine Bioavailability And DDI’s In Humans -- Management Of Drug Interactions Of New Drugs In Multicenter Trials Using The Metabolism & Transport Drug Interaction Database© -- Web-Based Database As A Tool To Examine Drug-Drug Interactions Involving Transporters -- Drug Disposit... Mostrar Tudo