Data/hora: 16/06/2024 06:09:20

Biblioteca(s): | Embrapa Caprinos e Ovinos.
Data corrente: | 01/08/1992
Data da última atualização: | 08/11/2023
Autoria: | ROBINSON, T. J.; BRANDER, W. M.
Título: | Comparative activies of a number of oestrogens when administered intravenously and intramusculary in the sheep.
Ano de publicação: | 1962
Fonte/Imprenta: | Journal of Reproduction and Fertility, v. 3, n. 1, p. 74-88, Feb. 1962.
DOI: | 10.1530/jrf.0.0030074
Idioma: | Inglês
Conteúdo: | Abstract: The activities of six oestrogenic substances were compared when given as a single injection, intravenously (i/v) or intramuscularly (i/m), to spayed progesterone-primed ewes. The following values for the ED50 for oestrous behaviour, with associated 95% fiducial limits, were obtained: Oestradiol-17? (i/v) 16 ?, 25 ? 39; (i/m) 3 ? 7 ? 16; Oestradiol benzoate (i/v) 30 ? 45 ? 69; (i/m) 5 ? 11 ? 23; Oestrone (i/v) 48 ? 96 ? 194; (i/m) No data; Diethylstilboestrol (i/v) 6 ? 10 ? 18; (i/m) 6 ? 10 ? 18; Hexoestrol (i/v) 46 ? 103 ? 234; (i/m) 46 ? 103 ? 234; Methylethylstilboestrol (i/v) ? ? ; (i/m) 130 ? 279 ? 600; They fell into three groups, with the following i/v : i/m ratios: natural oestrogens; oestradiol- 17?, oestradiol benzoate, 4 : 1: synthetic oestrogens; diethylstilboestrol and hexoestrol, 1 : 1 : pro-oestrogen; methylethylstilboestrol, ? : 1. True oestrogens are presumed to accumulate in the reacting tissues with variable efficiencies. Pro-oestrogens, given i/v, are probably ineffective because they are not converted to oestrogens in a manner or at a rate suitable for such accumulation.
Palavras-Chave: | Estradiol Congeners.
Thesagro: | Endocrinologia; Estrógeno; Fisiologia; Hormônio; Ovino; Reprodução.
Thesaurus Nal: | Animal reproduction; Estrogens; Estrus; Intramuscular injection; Pharmacology; Sheep.
Categoria do assunto: | L Ciência Animal e Produtos de Origem Animal
Registro original: | Embrapa Caprinos e Ovinos (CNPC)
Exemplares: | CNPC - (6519-1) - ADD - AP - DD -  -  -  - DIS