Data/hora: 25/05/2024 07:57:34

Biblioteca(s): 	Embrapa Agroenergia.	
Data corrente: 	05/07/2017	
Data da última atualização: 	12/01/2018	
Autoria: 	MOURA, L. T. S.; SOUZA, D. P. M.; MENDONCA, S.; RIBEIRO, J. A. de A.; SOUSA, L. F.; RAMOS, A. T.; MAIORKA, P. C.; ARAÚJO, V. L.; MARUO, V. M.	
Afiliação: 	LAIANE TEIXEIRA SOUSA MOURA; DOMENICA PALOMARIS MARIANO SOUZA; SIMONE MENDONCA, CNPAE; JOSE ANTONIO DE AQUINO RIBEIRO, CNPAE; LUCIANO FERNANDES SOUSA; ADRIANO TONY RAMOS; PAULO CÉSAR MAIORKA; VERA LÚCIA DE ARAÚJO; VIVIANE MAYUMI MARUO.	
Título: 	Histopathological and Reproductive Evaluation in Male Rats Fed Jatropha curcas Seed Cake with or without Alkaline Hydrolysis and Subjected to Heat Treatment.	
Ano de publicação: 	2017	
Fonte/Imprenta: 	BioMed Research International, v. 2017, artigo 6123408 , 2017.	
DOI: 	10.1155/2017/6123408	
Idioma: 	Inglês	
Conteúdo: 	Jatropha curcas cake, a by-product of biodiesel production, is rich in protein and has potential to be used in livestock feed; however, the presence of antinutritional factors and phorbol esters limits its use.Thus, this study investigated toxicological and reproductive effects in maleWistar rats after subchronic exposure to J. curcas cake subjected to detoxification procedures. Rats were divided into seven groups (&#119899; = 10) and treated for 60 days.The control group received commercial feed, while experimental groups received a diet containing 5% J. curcas cake nonhydrolyzed or hydrolyzed with 5MNaOH. The cakes were unwashed or washed with ethanol or water and were autoclaved at 121&#8728;C for 30 minutes. Alkaline hydrolysis combined with ethanol washing decreased the phorbol ester concentration in the cake by 98%. Histopathological findings included diffuse degeneration of the liver and edema around the pulmonary vessels in the nonhydrolyzed groups. In addition, nontreated females mated with males of nonhydrolyzed unwashed group showed a decreased number of live fetuses and an increased placental weight. There were no signs of toxicity in rats given hydrolyzed cakes washed and unwashed, indicating that alkaline hydrolysis associated with heat treatment is an efficient method for detoxification of the J. curcas cake.	
Palavras-Chave: 	Efeitos reprodutivos; Efeitos toxicológicos; Exposição subcrônica; Ratos machoWistar.	
Thesagro: 	Desintoxicação; Jatropha Curcas.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Agroenergia (CNPAE)	
Exemplares: 	CNPAE - (3142-1) - UPC - AP - DD -  -  -  - DIS