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![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
Registro Completo |
Biblioteca(s): |
Embrapa Gado de Leite. |
Data corrente: |
19/12/2018 |
Data da última atualização: |
24/01/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
DIAS, A. T.; CASTRO, S. B. R. de; ALVES, C. C. de S.; EVANGELISTA, M. G.; SILVA, L. C. da; REIS, D. R. de L.; MACHADO, M. A.; JULIANO, M. A.; FERREIRA, A. P. |
Afiliação: |
ALYRIA TEIXEIRA DIAS, UFJF; SANDRA BERTELLI RIBEIRO DE CASTRO, UFJF; CAIO CÉSAR DE SOUZA ALVES, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Teófilo Otoni; MARCILENE GOMES EVANGELISTA, UFJF; LUAN CRISTIAN DA SILVA, UFJF; DANIELE RIBEIRO DE LIMA REIS FAZA, CNPGL; MARCO ANTONIO MACHADO, CNPGL; MARIA APARECIDA JULIANO, Universidade Federal de São Paulo; ANA PAULA FERREIRA, UFJF. |
Título: |
Genistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Inflammation Research, v. 67, n. 7, p. 597-608, 2018. |
DOI: |
10.1007/s00011-018-1146-7 |
Idioma: |
Inglês |
Conteúdo: |
Abstract OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s.c. and were initiated 2 days before the immunization and continued daily until day 6 postimmunization. METHODS: Animals were monitored daily for clinical signs of EAE up to day 21. Inflammatory infiltration, demyelination, Toll-like receptor (TLR) expression, cytokines and transcription factors were analyzed in spinal cords. RESULTS: The present study demonstrates, for the first time, the genistein ability to modulate the factors involved in the innate immune response in the early stages of EAE. The genistein therapy delayed the onset of the disease, with reduced inflammatory infiltration and demyelination. In addition, the expression of TLR3, TLR9 and IFN-β were increased in genistein group, with reduction in the factors of TH1 and Th17 cells. CONCLUSION: These findings shed light on the potential of genistein as a prophylactic strategy for multiple sclerosis (MS) prevention. |
Palavras-Chave: |
Experimental autoimmune encephalomyelitis; IFN-beta; Multiple sclerosis; Toll-like. |
Thesaurus Nal: |
Immune response. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
Marc: |
LEADER 02278naa a2200289 a 4500 001 2102082 005 2023-01-24 008 2018 bl uuuu u00u1 u #d 024 7 $a10.1007/s00011-018-1146-7$2DOI 100 1 $aDIAS, A. T. 245 $aGenistein modulates the expression of Toll-like receptors in experimental autoimmune encephalomyelitis.$h[electronic resource] 260 $c2018 520 $aAbstract OBJECTIVE AND DESIGN: The present work investigates the modulation of experimental autoimmune encephalomyelitis (EAE) using genistein before the EAE induction. MATERIAL: Female C57BL/6 mice (n = 96 mice/experiment), 4-6 weeks old, were used to induce the EAE. The mice were divided into three experimental groups: non-immunized group, immunized group (EAE), and immunized and treated with genistein group (Genistein). TREATMENT: Genistein was used at a dose of 200 mg/kg s.c. and were initiated 2 days before the immunization and continued daily until day 6 postimmunization. METHODS: Animals were monitored daily for clinical signs of EAE up to day 21. Inflammatory infiltration, demyelination, Toll-like receptor (TLR) expression, cytokines and transcription factors were analyzed in spinal cords. RESULTS: The present study demonstrates, for the first time, the genistein ability to modulate the factors involved in the innate immune response in the early stages of EAE. The genistein therapy delayed the onset of the disease, with reduced inflammatory infiltration and demyelination. In addition, the expression of TLR3, TLR9 and IFN-β were increased in genistein group, with reduction in the factors of TH1 and Th17 cells. CONCLUSION: These findings shed light on the potential of genistein as a prophylactic strategy for multiple sclerosis (MS) prevention. 650 $aImmune response 653 $aExperimental autoimmune encephalomyelitis 653 $aIFN-beta 653 $aMultiple sclerosis 653 $aToll-like 700 1 $aCASTRO, S. B. R. de 700 1 $aALVES, C. C. de S. 700 1 $aEVANGELISTA, M. G. 700 1 $aSILVA, L. C. da 700 1 $aREIS, D. R. de L. 700 1 $aMACHADO, M. A. 700 1 $aJULIANO, M. A. 700 1 $aFERREIRA, A. P. 773 $tInflammation Research$gv. 67, n. 7, p. 597-608, 2018.
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Embrapa Gado de Leite (CNPGL) |
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![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Algodão. Para informações adicionais entre em contato com cnpa.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Algodão. |
Data corrente: |
24/11/2011 |
Data da última atualização: |
24/11/2011 |
Tipo da produção científica: |
Artigo em Anais de Congresso |
Autoria: |
FRANÇA, P. R. C. DE.; SILVA, J. B.; SILVA, O. R. R. F.; MEDEIROS, E. P. de; MORAIS, J. P. S. |
Afiliação: |
PABLO RADAMÉS CABRAL DE FRANÇA; JOAN BRUNO SILVA; ODILON RENY RIBEIRO FERREIRA SILVA, CNPA; EVERALDO PAULO DE MEDEIROS, CNPA; JOAO PAULO SARAIVA MORAIS, CNPA. |
Título: |
Capacidade extrativa de sumo de sisal utilizando resíduos de Agave Sisalana e do Agave Híbrido 11648. |
Ano de publicação: |
2010 |
Fonte/Imprenta: |
In: CONGRESSO PARAIBANO DE AGROECOLOGIA, 1.; FÓRUM SOBRE O REGISTRO PROFISSIONAL DO AGROECÓLOGO, 4., 2010, Lagoa Seca. Anais... Lagoa Seca: UEPB; SEBRAE; Embrapa Algodão, 2010. |
Páginas: |
5 p. |
Idioma: |
Português |
Palavras-Chave: |
Bioinseticida. |
Thesagro: |
Agave Sisalana; Agricultura Familiar; Extrato; Sisal. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00795nam a2200217 a 4500 001 1907205 005 2011-11-24 008 2010 bl uuuu u00u1 u #d 100 1 $aFRANÇA, P. R. C. DE. 245 $aCapacidade extrativa de sumo de sisal utilizando resíduos de Agave Sisalana e do Agave Híbrido 11648.$h[electronic resource] 260 $aIn: CONGRESSO PARAIBANO DE AGROECOLOGIA, 1.; FÓRUM SOBRE O REGISTRO PROFISSIONAL DO AGROECÓLOGO, 4., 2010, Lagoa Seca. Anais... Lagoa Seca: UEPB; SEBRAE; Embrapa Algodão$c2010 300 $a5 p. 650 $aAgave Sisalana 650 $aAgricultura Familiar 650 $aExtrato 650 $aSisal 653 $aBioinseticida 700 1 $aSILVA, J. B. 700 1 $aSILVA, O. R. R. F. 700 1 $aMEDEIROS, E. P. de 700 1 $aMORAIS, J. P. S.
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