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 | Acesso ao texto completo restrito à biblioteca da Embrapa Suínos e Aves. Para informações adicionais entre em contato com cnpsa.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
26/07/2021 |
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Data da última atualização: |
27/07/2021 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
TEIXEIRA, S. A.; MARQUES, D. B. D.; COSTA, T. C.; OLIVEIRA, H. C.; COSTA, K. A.; CARRARA, E. R.; SILVA, W. da; GUIMARÃES, J. D.; NEVES, M. N.; IBELLI, A. M. G.; CANTAO, M. E.; LEDUR, M. C.; PEIXOTO, J. de O.; GUIMARÃES, S. E. F. |
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Afiliação: |
SUSANA A. TEIXEIRA, UFV; DANIELE BOTELHO DINIZ MARQUES, UFV; THAÍS C. COSTA, UFV; HANIEL CEDRAZ DE OLIVEIRA, UFV; KARINE A. COSTA, UFV; EULA R. CARRARA, UFV; WALMIR DA SILVA, UFV; JOSÉ D. GUIMARÃES, UFV; MARIANA M. NEVES, UFV; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; MAURICIO EGIDIO CANTAO, CNPSA; MONICA CORREA LEDUR, CNPSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; SIMONE ELIZA FACIONI GUIMARÃES, UFV. |
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Título: |
Transcription landscape of the early developmental biology in pigs. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Animals, v. 11, n. 1443, 2021. |
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DOI: |
https://doi.org/10.3390/ani11051443 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Since pre- and postnatal development are programmed during early prenatal life, studies addressing the complete transcriptional landscape during organogenesis are needed. Therefore, we aimed to disentangle differentially expressed (DE) genes between fetuses (at 35 days old) and embryos (at 25 days old) through RNA-sequencing analysis using the pig as model. In total, 1705 genes were DE, including the top DE IBSP, COL6A6, HBE1, HBZ, HBB, and NEUROD6 genes, which are associated with developmental transition from embryos to fetuses, such as ossification, skeletal muscle development, extracellular matrix organization, cardiovascular system, erythrocyte differentiation, and neuronal system. In pathway analysis, embryonic development highlighted those mainly related to morphogenic signaling and cell interactions, which are crucial for transcriptional control during the establishment of the main organs in early prenatal development, while pathways related to myogenesis, neuronal development, and cardiac and striated muscle contraction were enriched for fetal development, according to the greater complexity of organs and body structures at this developmental stage. Our findings provide an exploratory and informative transcriptional landscape of pig organogenesis, which might contribute to further studies addressing specific developmental events in pigs and in other mammals. |
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Palavras-Chave: |
Desenvolvimento pré-natal; RNA-seq. |
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Thesagro: |
Organogénese; Reprodução Animal; Suíno. |
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Thesaurus NAL: |
Organogenesis; Prenatal development; Swine. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02456naa a2200385 a 4500
001 2133113
005 2021-07-27
008 2021 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3390/ani11051443$2DOI
100 1 $aTEIXEIRA, S. A.
245 $aTranscription landscape of the early developmental biology in pigs.$h[electronic resource]
260 $c2021
520 $aAbstract: Since pre- and postnatal development are programmed during early prenatal life, studies addressing the complete transcriptional landscape during organogenesis are needed. Therefore, we aimed to disentangle differentially expressed (DE) genes between fetuses (at 35 days old) and embryos (at 25 days old) through RNA-sequencing analysis using the pig as model. In total, 1705 genes were DE, including the top DE IBSP, COL6A6, HBE1, HBZ, HBB, and NEUROD6 genes, which are associated with developmental transition from embryos to fetuses, such as ossification, skeletal muscle development, extracellular matrix organization, cardiovascular system, erythrocyte differentiation, and neuronal system. In pathway analysis, embryonic development highlighted those mainly related to morphogenic signaling and cell interactions, which are crucial for transcriptional control during the establishment of the main organs in early prenatal development, while pathways related to myogenesis, neuronal development, and cardiac and striated muscle contraction were enriched for fetal development, according to the greater complexity of organs and body structures at this developmental stage. Our findings provide an exploratory and informative transcriptional landscape of pig organogenesis, which might contribute to further studies addressing specific developmental events in pigs and in other mammals.
650 $aOrganogenesis
650 $aPrenatal development
650 $aSwine
650 $aOrganogénese
650 $aReprodução Animal
650 $aSuíno
653 $aDesenvolvimento pré-natal
653 $aRNA-seq
700 1 $aMARQUES, D. B. D.
700 1 $aCOSTA, T. C.
700 1 $aOLIVEIRA, H. C.
700 1 $aCOSTA, K. A.
700 1 $aCARRARA, E. R.
700 1 $aSILVA, W. da
700 1 $aGUIMARÃES, J. D.
700 1 $aNEVES, M. N.
700 1 $aIBELLI, A. M. G.
700 1 $aCANTAO, M. E.
700 1 $aLEDUR, M. C.
700 1 $aPEIXOTO, J. de O.
700 1 $aGUIMARÃES, S. E. F.
773 $tAnimals$gv. 11, n. 1443, 2021.
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