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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
31/05/1993 |
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Data da última atualização: |
17/02/2016 |
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Autoria: |
FAGGIN, B. M.; PALERMO NETO, J. |
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Afiliação: |
B. M. FAGGIN, CNPMA. |
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Título: |
Differential alterations in brain sensivity to amphetamine and pentylenetetrazol in socially deprived mice. |
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Ano de publicação: |
1985 |
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Fonte/Imprenta: |
General Pharmacology, v.16, n.3, p.299-302, 1985. |
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Idioma: |
Inglês |
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Conteúdo: |
Mice deprived of social interactions for different periods of time (56, 69, 79, 89 or 97 days) were studied. Social isolation increased both general activity observed in an open-field and amphetamine-induced hyperactivity; CNS responsiveness to pentylenetetrazol-induced convulsions; however, decreased. The differences in general activity were detected after 69 and 79 days of social deprivation; the hyperactivity induced by amphetamine was greater after 79 days of isolation and the pentylenetetrazol CD50s were higher after 56, 69 and 79 days solitude. These data, obtained with mice, show first that isolation time is an important variable to display drug effects and secondly that long-term deprivation of social stimuli does not increase CNS susceptibility to all stimulant drugs. A combination of a higher release of catecholamines onto previously supersensitive receptors was considered to be involved with the differences observed. |
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Palavras-Chave: |
Atividade; Estimulante; Isolation; Stimulant activity. |
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Thesagro: |
Camundongo; Isolamento. |
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Thesaurus Nal: |
mice. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01567naa a2200217 a 4500
001 1010489
005 2016-02-17
008 1985 bl uuuu u00u1 u #d
100 1 $aFAGGIN, B. M.
245 $aDifferential alterations in brain sensivity to amphetamine and pentylenetetrazol in socially deprived mice.$h[electronic resource]
260 $c1985
520 $aMice deprived of social interactions for different periods of time (56, 69, 79, 89 or 97 days) were studied. Social isolation increased both general activity observed in an open-field and amphetamine-induced hyperactivity; CNS responsiveness to pentylenetetrazol-induced convulsions; however, decreased. The differences in general activity were detected after 69 and 79 days of social deprivation; the hyperactivity induced by amphetamine was greater after 79 days of isolation and the pentylenetetrazol CD50s were higher after 56, 69 and 79 days solitude. These data, obtained with mice, show first that isolation time is an important variable to display drug effects and secondly that long-term deprivation of social stimuli does not increase CNS susceptibility to all stimulant drugs. A combination of a higher release of catecholamines onto previously supersensitive receptors was considered to be involved with the differences observed.
650 $amice
650 $aCamundongo
650 $aIsolamento
653 $aAtividade
653 $aEstimulante
653 $aIsolation
653 $aStimulant activity
700 1 $aPALERMO NETO, J.
773 $tGeneral Pharmacology$gv.16, n.3, p.299-302, 1985.
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