Data/hora: 06/06/2024 04:32:24

Biblioteca(s): 	Embrapa Milho e Sorgo.	
Data corrente: 	25/04/2022	
Data da última atualização: 	09/11/2022	
Autoria: 	VEREDIANO, T. A.; MARTINO, H. S. D.; KOLBA, N.; FU, I.; PAES, M. C. D.; TAKO, E.	
Afiliação: 	THAISA AGRIZZI VEREDIANO, Cornell University; HÉRCIA STAMPINI DUARTE MARTINO, Universidade Federal de Viçosa; NIKOLAI KOLBA, Cornell University; YIMIN FU, Cornell University; MARIA CRISTINA DIAS PAES, CNPMS; ELAD TAKO, Cornell University.	
Título: 	Black corn (Zea mays L.) soluble extract showed anti-inflammatory effects and improved the intestinal barrier integrity in vivo (Gallus gallus).	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Food Research International, v. 157, 111227, 2022.	
DOI: 	https://doi.org/10.1016/j.foodres.2022.111227	
Idioma: 	Inglês	
Conteúdo: 	Black corn (Zea mays L.) is a pigmented type of this cereal whose color of the kernels is attributed to the presence of the anthocyanins. In this study, we assessed the black corn soluble extract (BCSE) effects on the intestinal functionality, morphology, and microbiota composition using an in vivo model (Gallus gallus) by an intraamniotic administration. The eggs were divided into four groups (n = 6?10): (1) No Injection; (2) 18 M&#8486; H2O/cm; (3) 5% (5 mg/mL) BCSE; (4) 15% (15 mg/mL) BCSE. The BCSE showed anti-inflammatory effects by down regulating the gene expression of tumor necrosis factor-alpha (TNF-&#945;), interleukin 6 (IL6), and the transcriptional nuclear factor kappa beta (NF-&#954;B). Further, the BCSE increased the relative abundance of E. coli and Clostridium. 5% and 15% BCSE increased the hepatic glycogen and upregulated the gene expression of sodiumglucose transport protein (SGLT1). In the morphology, 5% and 15% BCSE increased the goblet cell (GC) number on the crypt, the GC size on the villi, Paneth cell number on the crypt, and the acid GC. Further, the BCSE strengthened the epithelial physical barrier through upregulating the intestinal biomarkers AMP- activated protein kinase (AMPK) and caudal-related homeobox transcriptional factor 2 (CDX2). The overall result suggests that the BCSE promotes intestinal anti-inflammatory effects as well as enhances the intestinal barrier function.	
Palavras-Chave: 	Barreira intestinal; Célula cálice; Cianidina; Goblet cell; Intestinal barrier; Intestinal morphology; Intra-amniotic; Intra-amniótico; Milho preto; Morfologia intestinal; Polifenóis.	
Thesagro: 	Antocianina; Milho.	
Thesaurus Nal: 	Anthocyanins; Cyanidin; Polyphenols.	
Categoria do assunto: 	F Plantas e Produtos de Origem Vegetal	
Registro original: 	Embrapa Milho e Sorgo (CNPMS)	
Exemplares: 	CNPMS - (29803-1) - UPC - AP - DD -  -  -  - DIS