Data/hora: 16/06/2024 07:26:48

Biblioteca(s): | Embrapa Agricultura Digital; Embrapa Pecuária Sudeste.
Data corrente: | 26/07/2022
Data da última atualização: | 10/11/2022
Autoria: | CARDOSO, T. F.; BRUSCADIN, J. J.; AFONSO, J.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; MALHEIROS, J. M.; ROCHA, M. I. P.; ZERLOTINI NETO, A.; FERRAZ, J. B. S.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A.
Afiliação: | UFSCar; ESALQ/USP; Munster Technological University; UFSCar; Federal University of Latin American Integration, Foz do Iguaçu; UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; FZEA/USP; ESALQ/USP; ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE.
Título: | EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.
Ano de publicação: | 2022
Fonte/Imprenta: | Mammalian Genome, v. 33, n. 4, p. 619-628, Dec. 2022.
DOI: | https://doi.org/10.1007/s00335-022-09959-8
Idioma: | Inglês
Conteúdo: | Abstract. Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes? expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (? = 3.02; P-value = 3.51E-03) and the residual feed intake trait (? = -3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, coexpression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle.
Palavras-Chave: | Cofatores de transcrição; Expressão gênica; Fatores de transcrição; Loci de característica quantitativa; Nelore cattle; Polimorfismos de nucleotídeo único.
Thesagro: | Gado Nelore.
Thesaurus Nal: | Gene expression; Quantitative trait loci; Single nucleotide polymorphism; Transcription (genetics); Transcription factors.

Categoria do assunto:

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G Melhoramento Genético

Registro original: | Embrapa Agricultura Digital (CNPTIA)

Exemplares:

CNPTIA - (21230-1) - UPC - AP - DD -  -  -  - DIS
CPPSE - (25684-1) - UPC - AP - DD - PROCI-2022.00052 - CAR - 2022.00107 - DIS