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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite. |
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Data corrente: |
30/10/2021 |
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Data da última atualização: |
03/10/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OLIVEIRA, E. R.; FAYER, L.; ZANETTE, R. S. S.; LADEIRA, L. O.; OLIVEIRA, L. F. C. de; MARANDUBA, C. M. C.; BRANDAO, H. de M.; MUNK, M. |
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Afiliação: |
EDUARDA R. OLIVEIRA, Universidade Federal de Juiz de Fora; LEONARA FAYER, Universidade Federal de Juiz de Fora; RAFAELLA S. S. ZANETTE, Universidade Federal de Juiz de Fora; LUIZ O. LADEIRA, Universidade Federal de Minas Gerais; LUIZ F. C. DE OLIVEIRA, Universidade Federal de Juiz de Fora; CARLOS M. C. MARANDUBA, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, Universidade Federal de Juiz de Fora. |
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Título: |
Cytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Nanotechnology, v. 33, n. 6, 065101, 2022. |
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DOI: |
https://doi.org/10.1088/1361-6528/ac335b |
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Idioma: |
Inglês |
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Conteúdo: |
Carboxylated Multi-wall Carbon Nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNTCOOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields. |
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Palavras-Chave: |
Células-tronco; Engenharia de tecido; Estudo in vitro; Nanotecnologia. |
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Thesagro: |
Carbono. |
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Categoria do assunto: |
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1135728/1/Cytocompatibility-of-carboxylated-multi-wall-carbon-nanotubes-in-stem-cells-.pdf
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Marc: |
LEADER 01878naa a2200277 a 4500
001 2135728
005 2023-10-03
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1088/1361-6528/ac335b$2DOI
100 1 $aOLIVEIRA, E. R.
245 $aCytocompatibility of carboxylated multi-wall carbon nanotubes in stem cells from human exfoliated deciduous teeth.$h[electronic resource]
260 $c2022
520 $aCarboxylated Multi-wall Carbon Nanotube (MWCNT-COOH) presents unique properties due to nanoscale dimensions and permits a broad range of applications in different fields, such as bone tissue engineering and regenerative medicine. However, the cytocompatibility of MWCNT-COOH with human stem cells is poorly understood. Thus, studies elucidating how MWCNT-COOH affects human stem cell viability are essential to a safer application of nanotechnologies. Using stem cells from the human exfoliated deciduous teeth model, we have evaluated the effects of MWCNT-COOH on cell viability, oxidative cell stress, and DNA integrity. Results demonstrated that despite the decreased metabolism of mitochondria, MWCNT-COOH had no toxicity against stem cells. Cells maintained viability after MWCNT-COOH exposure. MWCNTCOOH did not alter the superoxide dismutase activity and did not cause genotoxic effects. The present findings are relevant to the potential application of MWCNT-COOH in the tissue engineering and regenerative medicine fields.
650 $aCarbono
653 $aCélulas-tronco
653 $aEngenharia de tecido
653 $aEstudo in vitro
653 $aNanotecnologia
700 1 $aFAYER, L.
700 1 $aZANETTE, R. S. S.
700 1 $aLADEIRA, L. O.
700 1 $aOLIVEIRA, L. F. C. de
700 1 $aMARANDUBA, C. M. C.
700 1 $aBRANDAO, H. de M.
700 1 $aMUNK, M.
773 $tNanotechnology$gv. 33, n. 6, 065101, 2022.
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Embrapa Gado de Leite (CNPGL) |
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