Data/hora: 13/06/2024 01:41:52

Biblioteca(s): | Embrapa Gado de Leite; Embrapa Instrumentação.
Data corrente: | 06/09/2023
Data da última atualização: | 13/09/2023
Autoria: | ZANETTE, R. de S. S.; FAYER, L.; VASCONCELLOS, R.; OLIVEIRA, L. F. C. de; MARANDUBA, C. M. da C.; ALVARENGA, E. L. F. C. de; MARTINS, M. A.; BRANDAO, H. de M.; MUNK, M.
Afiliação: | RAFAELLA DE SOUZA SALOMÃO ZANETTE, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; LEONARA FAYER, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; REBECCA VASCONCELLOS, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; LUIZ FERNANDO CAPPA DE OLIVEIRA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; CARLOS MAGNO DA COSTA MARANDUBA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; ERIKA LORENA FONSECA COSTA DE ALVARENGA, UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REY; MARIA ALICE MARTINS, CNPDIA; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, UNIVERSIDADE FEDERAL DE JUIZ DE FORA.
Título: | Cytocompatible and osteoinductive cotton cellulose nanofiber/chitosan nanobiocomposite scaffold for bone tissue engineering.
Ano de publicação: | 2023
Fonte/Imprenta: | Biomedical Materials, v. 18, 055016, 2023.
DOI: | http://doi.org/10.1088/1748-605X/aceac8
Idioma: | Inglês
Conteúdo: | Natural polymeric nanobiocomposites hold promise in repairing damaged bone tissue in tissue engineering. These materials create an extracellular matrix (ECM)-like microenvironment that induces stem cell differentiation. In this study, we investigated a new cytocompatible nanobiocomposite made from cotton cellulose nanofibers (CNFs) combined with chitosan polymer to induce osteogenic stem cell differentiation. First, we characterized the chemical composition, nanotopography, swelling properties, and mechanical properties of the cotton CNF/chitosan nanobiocomposite scaffold. Then, we examined the biological characteristics of the nanocomposites to evaluate their cytocompatibility and osteogenic differentiation potential using human mesenchymal stem cells derived from exfoliated deciduous teeth. The results showed that the nanobiocomposite exhibited favorable cytocompatibility and promoted osteogenic differentiation of cells without the need for chemical inducers, as demonstrated by the increase in alkaline phosphatase activity and ECM mineralization. Therefore, the cotton CNF/chitosan nanobiocomposite scaffold holds great promise for bone tissue engineering applications.
Palavras-Chave: | Biomedical nanomaterials; Human mesenchymal; Nanofibra; Tecido ósseo.
Thesagro: | Algodão; Célula; Celulose.
Thesaurus Nal: | Cell differentiation; Nanomaterials; Stem cells.
Categoria do assunto: | G Melhoramento Genético
Registro original: | Embrapa Instrumentação (CNPDIA)

Exemplares:

CNPGL - (26094-1) - UPC - AP - DD -  -  -  - DIS
CNPDIA - (18271-1) - UPC - AP - DD - PROCI.23/81 -  - 2023/86 - DIS