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Registro Completo |
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
Data corrente: |
01/09/2016 |
Data da última atualização: |
19/03/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
SOUZA, M. M. de; NICIURA, S. C. M.; TIZIOTO, P. C.; IBELLI, A. M. G.; GASPARIN, G.; ROCHA, M. I. P.; DONATONI, F. A. B.; MALAGO JUNIOR, W.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; LIMA, A. O.; MUDADU, M. de A.; BARIONI JUNIOR, W.; COUTINHO, L. L.; REGITANO, L. C. de A. |
Afiliação: |
M.M. de Souza, UFSCAR; SIMONE CRISTINA MEO NICIURA, CPPSE; P.C. Tizioto, FAPESP; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; G. Gasparin, USP-ESALQ; M. I. P. Rocha, UFSCAR; FLAVIA ALINE BRESSANI DONATONI, CPPSE; WILSON MALAGO JUNIOR, CPPSE; W. J. S. Diniz, UFSCAR; Priscila Silva Neubern de Oliveira, FAPESP; A. O. Lima, UFSCAR; MAURICIO DE ALVARENGA MUDADU, CNPTIA; WALDOMIRO BARIONI JUNIOR, CPPSE; L. L. Coutinho, USP-ESALQ; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
Título: |
Allele- and parent-of-origin-specific effects on expression of the KCNJ11 gene: a candidate for meat tenderness in cattle. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Genetics and Molecular Research, v.15, n.3, aug. 2016. |
Volume: |
15 |
DOI: |
http://dx.doi.org/10.4238/gmr.15038549 |
Idioma: |
Inglês Português |
Conteúdo: |
In contrast to the Mendelian inheritance model, parental alleles can contribute unequally to gene expression, which may result in phenotypic variance among individuals and bias in the predicted additive effect of molecular markers associated with production traits. Given the need to understand the effects of allelic variation and parent-of-origin effects on the expression of genes with a commercial interest in cattle, we analyzed the expression of KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11), which was previously described as a functional candidate gene for meat tenderness. Allele-specific and parent-of-origin-dependent expression of this gene were assessed in bovine muscle using the rs379610823 single nucleotide polymorphism as a reference. Biallelic expression was observed; however, the T allele was expressed at significantly higher levels than the C allele. Furthermore, increased expression of KCNJ11 was found in animals harboring the maternal T allele. This study is the first to describe the differential allelic expression of bovine KCNJ11. Our findings are important for understanding the mechanisms that underlie the pattern of KCNJ11 expression and its potential impact on the phenotypic variation of meat tenderness in Nelore beef cattle. This reinforces the need for further investigation of allelic- and parent-of-origin expression deviation in genetic markers eligible for the selection of target traits. |
Palavras-Chave: |
Differential allelic expression; Expressão alélica diferencial; Maciez da carne; Nelore; Potassium inwardly rectifying channel. |
Thesagro: |
Gado de corte; Gado Nelore; Gado Zebu. |
Thesaurus Nal: |
Alleles; Beef cattle; Meat tenderness; Nellore; Zebu. |
Categoria do assunto: |
G Melhoramento Genético X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/147026/1/Souza-et-al-2016.pdf
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Marc: |
LEADER 02862naa a2200481 a 4500 001 2052240 005 2019-03-19 008 2016 bl uuuu u00u1 u #d 024 7 $ahttp://dx.doi.org/10.4238/gmr.15038549$2DOI 100 1 $aSOUZA, M. M. de 245 $aAllele- and parent-of-origin-specific effects on expression of the KCNJ11 gene$ba candidate for meat tenderness in cattle.$h[electronic resource] 260 $c2016 300 $a15 490 $v15 520 $aIn contrast to the Mendelian inheritance model, parental alleles can contribute unequally to gene expression, which may result in phenotypic variance among individuals and bias in the predicted additive effect of molecular markers associated with production traits. Given the need to understand the effects of allelic variation and parent-of-origin effects on the expression of genes with a commercial interest in cattle, we analyzed the expression of KCNJ11 (potassium inwardly rectifying channel, subfamily J, member 11), which was previously described as a functional candidate gene for meat tenderness. Allele-specific and parent-of-origin-dependent expression of this gene were assessed in bovine muscle using the rs379610823 single nucleotide polymorphism as a reference. Biallelic expression was observed; however, the T allele was expressed at significantly higher levels than the C allele. Furthermore, increased expression of KCNJ11 was found in animals harboring the maternal T allele. This study is the first to describe the differential allelic expression of bovine KCNJ11. Our findings are important for understanding the mechanisms that underlie the pattern of KCNJ11 expression and its potential impact on the phenotypic variation of meat tenderness in Nelore beef cattle. This reinforces the need for further investigation of allelic- and parent-of-origin expression deviation in genetic markers eligible for the selection of target traits. 650 $aAlleles 650 $aBeef cattle 650 $aMeat tenderness 650 $aNellore 650 $aZebu 650 $aGado de corte 650 $aGado Nelore 650 $aGado Zebu 653 $aDifferential allelic expression 653 $aExpressão alélica diferencial 653 $aMaciez da carne 653 $aNelore 653 $aPotassium inwardly rectifying channel 700 1 $aNICIURA, S. C. M. 700 1 $aTIZIOTO, P. C. 700 1 $aIBELLI, A. M. G. 700 1 $aGASPARIN, G. 700 1 $aROCHA, M. I. P. 700 1 $aDONATONI, F. A. B. 700 1 $aMALAGO JUNIOR, W. 700 1 $aDINIZ, W. J. S. 700 1 $aOLIVEIRA, P. S. N. de 700 1 $aLIMA, A. O. 700 1 $aMUDADU, M. de A. 700 1 $aBARIONI JUNIOR, W. 700 1 $aCOUTINHO, L. L. 700 1 $aREGITANO, L. C. de A. 773 $tGenetics and Molecular Research$gv.15, n.3, aug. 2016.
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Embrapa Pecuária Sudeste (CPPSE) |
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Registro Completo
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
18/09/2003 |
Data da última atualização: |
23/05/2013 |
Tipo da produção científica: |
Resumo em Anais de Congresso |
Autoria: |
MAFFILI, V. V.; TORRES, C. A. A.; FONSECA, J. F.; PROSPERI, C. P.; PONTES, R. A. M.; SANTOS, A. D. F.; MORAES, E. A. |
Afiliação: |
CNPC. |
Título: |
Taxa de gestação de cabras das raças Alpina e Saanen tratadas com gonadotrofina coriônica humana no quinto e vigésimo dia após a monta natural. |
Ano de publicação: |
2003 |
Fonte/Imprenta: |
Acta Scientiae Veterinariae, Porto Alegre, v. 31, p. 446, 2003. Suplemento. |
Idioma: |
Português |
Notas: |
Edição de anais da 17a. Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Beberibe, CE, ago. 2003. |
Palavras-Chave: |
Raça Alpina; Taxa de prenhez. |
Thesagro: |
Caprino; Endocrinologia; Gonadotrofina; Reprodução Animal. |
Thesaurus NAL: |
Saanen. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/83307/1/RAC-Taxa-de-gestacao.pdf
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Marc: |
LEADER 00948nam a2200265 a 4500 001 1529758 005 2013-05-23 008 2003 bl uuuu u00u1 u #d 100 1 $aMAFFILI, V. V. 245 $aTaxa de gestação de cabras das raças Alpina e Saanen tratadas com gonadotrofina coriônica humana no quinto e vigésimo dia após a monta natural. 260 $aActa Scientiae Veterinariae, Porto Alegre, v. 31, p. 446, 2003. Suplemento.$c2003 500 $aEdição de anais da 17a. Reunião Anual da Sociedade Brasileira de Tecnologia de Embriões, Beberibe, CE, ago. 2003. 650 $aSaanen 650 $aCaprino 650 $aEndocrinologia 650 $aGonadotrofina 650 $aReprodução Animal 653 $aRaça Alpina 653 $aTaxa de prenhez 700 1 $aTORRES, C. A. A. 700 1 $aFONSECA, J. F. 700 1 $aPROSPERI, C. P. 700 1 $aPONTES, R. A. M. 700 1 $aSANTOS, A. D. F. 700 1 $aMORAES, E. A.
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