Data/hora: 23/06/2024 23:28:07

Biblioteca(s): 	Embrapa Agroindústria de Alimentos.	
Data corrente: 	16/06/2015	
Data da última atualização: 	24/06/2016	
Autoria: 	PEIXOTO, A. G.; VIEIRA, T. O.; MELO, B. T. A.; NASCIMENTO, C. C. H. C.; AZEVEDO, L. A. C.; CAMACHO, A. C. L. F.; OLIVEIRA, J. F. F.; GOMES, M. L.; BARROS NETO, L. C. de; NASCIMENTO, S. F.; NOGUEIRA, R. I.; BARRETO, A. S.; DIRÉ, G. F.	
Afiliação: 	A. G. PEIXOTO, UEZO; T. O. VIEIRA, UEZO; B. T. A. MELLO, UEZO; C. C. H. C. NASCIMENTO, UEZO; L. A. C. AZEVEDO, FAETEC/Rio de Janeiro; A. C. L. F. CAMACHO, UFF; J. F. F. OLIVEIRA, UNESA; M. L. GOMES, INCa; L. C. DE BARROS NETO, UNIABEU, Rio de Janeiro; S. F. NASCIMENTO, UNESA; REGINA ISABEL NOGUEIRA, CTAA; A. S. BARRETO, UEZO; G. F. DIRÉ, UEZO.	
Título: 	Study of the biological effects of a hydroalcoholic extract of PUNICA GRANATUM (POMEGRANATE).	
Ano de publicação: 	2015	
Fonte/Imprenta: 	International Journal of Current Research in Chemistry and Pharmaceutical Sciences, v. 2, n. 6, p. 44-58, 2015.	
ISBN: 	2348-5221	
Idioma: 	Inglês	
Conteúdo: 	Herbal medicines are derived from medicinal plants and/or parts with known pharmacological characteristics. The use of these plants has been encouraged by the World Health Organization, as the culture use is still beneficial due to traditional factors and curative conferred its users. The development of antimicrobial drugs is important for the development of new sources for the therapeutic treatment of infectious diseases, considering that the characteristic of bacteria have become resistant to the action of antibiotics. Thus, aim of this study was to evaluate the influence of an alcoholic extract of the fruit peel of Punica granatum as its possible genotoxicity, cytotoxicity and mutagenic action against Staphylococcus aureus (ATCC 8096). To obtain the extract, the skins were dried, crushed and subjected to extraction with ethanol and, after that, the extract was placed on rotary evaporator. To assess cytotoxicity, we employed the method of nutrient agar diffusion disk. After standardization of turbidity of saline (0.9% NaCl) for UFC comparing with the scale of 0.5 Mc Farland was rated the bacterial growth front discs impregnated the presence of different volumes of extract and antibiotics. For the determination of genotoxicity and mutagenicity, beyond this extract were used as genotoxic and mutagenic agent’s hydrogen peroxide (H2O2) and Stannous Chloride (SnCl2). The results show that the extract in question has a similar effect of the antibiotics gentamicin and chloramphenicol and also that the extract has similar activity to the stannous chloride and hydrogen peroxide, which are agents that interfere with the bacterial genome. With the analysis of the results may suggest that the hydroalcoholic extract of the fruit peel of Punica granatum has cytotoxic, genotoxic and mutagenic action likely, but there is a need for more specific analyzes to elucidate the presence of this last feature.	
Palavras-Chave: 	Disk diffusion.	
Thesagro: 	Punica Granatum; Staphylococcus Aureus.	
Thesaurus Nal: 	genotoxicity; mutagenicity.	
Categoria do assunto: 	X Pesquisa, Tecnologia e Engenharia	
Registro original: 	Embrapa Agroindústria de Alimentos (CTAA)	
Exemplares: 	CTAA - (12736-1) - UPC - AP - DD -  -  -  - DIS