Data/hora: 21/06/2024 10:41:27

Biblioteca(s): 	Embrapa Agricultura Digital.	
Data corrente: 	26/11/2009	
Data da última atualização: 	15/01/2020	
Autoria: 	MAZONI, I.; BORRO, L. C.; MANCINI, A.; SALIM, J. A.; MORAES, F. R.; JARDINE, J. G.; NESHICH, I. P.; NESHICH, G.	
Afiliação: 	IVAN MAZONI, CNPTIA; L. C. BORRO, CNPTIA; ADAUTO LUIZ MANCINI, CNPTIA; JOSÉ AUGUSTO SALIM, Estagiário/CNPTIA; FABIO ROGERIO DE MORAES, Bolsista/CNPTIA; JOSE GILBERTO JARDINE, CNPTIA; IZABELLA PENA NESHICH, Estagiária/CNPTIA; GORAN NESHICH, CNPTIA.	
Título: 	Computational analysis of the secondary structure elements based on the physical chemical and geometrical descriptors and statistics data.	
Ano de publicação: 	2009	
Fonte/Imprenta: 	In: INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY, 5., 2009, Angra dos Reis. Abstracts book... Angra dos Reis: ABBCB, 2009.	
Páginas: 	Não paginado	
Idioma: 	Inglês	
Notas: 	X-Meeting 2009.	
Conteúdo: 	JSSD is software developed on the Java programming language, to analyze the secondary structure elements of the proteins. This analysis is based on the information about the amino acids physical chemical and geometrical parameters and allows characterize the functional proteins nanoenvironment, where the nucleation of secondary structure elements (alpha-helix, beta-sheets and loops) occurs (composed by initiation, propagation and termination). JSSD uses a database containing 720 different descriptors for each amino acid in any protein deposited in the PDB. Considering that each protein has 2 chains with 300 amino acids each one and there are more than 60000 structures deposited in the PDB, our database has 720 x 2 x 300 x 60,000 = 25,920,000,000 registers approximately. A first experiment was done with 40,710 proteins. We created data marts (extracts from PDB based on strict rules for selecting a particular characteristic) from these structures for the proteins families: all-alpha, all-beta and alpha + beta. Using only the amino acids sequence matching the initial and final position at selected secondary structure element and that has consensus on all three identifiers PDB, DSSP and Stride, the experiment showed that there are 34,095 alpha-helices on the all-alpha protein family; 8,645 beta-sheets on the all-beta protein family and 306,556 alpha-helices and 250,674 beta-sheets on the alpha + beta protein family (both secondary structure element of variable size starting from minimum 5 amino acids).	
Palavras-Chave: 	Análise computacional; Elementos de estrutura secundária; JSSD.	
Thesagro: 	Dados Estatísticos.	
Thesaurus Nal: 	Computer software.	
Categoria do assunto: 	X Pesquisa, Tecnologia e Engenharia	
Registro original: 	Embrapa Agricultura Digital (CNPTIA)	
Exemplares: 	CNPTIA - (14193-1) - UPC - RA - PP -  -  - 2009.00162 - DES
CNPTIA - (14193-2) - UPC - RA - DD -  -  -  - DIS