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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
23/06/2017 |
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Data da última atualização: |
23/06/2017 |
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Autoria: |
PICTON, H. M.; TSONIS, C. G.; MCNEILLY, A. S. |
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Título: |
FSH causes a time-dependent stimulation of preovulatory follicle growth in the absence of pulsatile LH secretion in ewes chronically treated with gonadotrophin-releasing hormone agonist. |
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Ano de publicação: |
1990 |
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Fonte/Imprenta: |
Journal of Endocrinology, v. 126, n. 2, p. 297-307, Aug. 1990. |
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DOI: |
10.1677/joe.0.1260297 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The study investigated the relationship between the plasma concentration of FSH and the stimulation of preovulatory follicle growth in vivo in ewes chronically treated with the gonadotrophin-releasing hormone (GnRH) agonist buserelin (HOE 766). Welsh Mountain ewes with regular oestrous cycles were treated for 6 weeks with two discs implants placed s.c., each containing 5 mg of the agonist in a matrix of polyhydroxybutyric acid. Treatment with the agonist for 35 days produced a sustained suppression of the plasma concentration of FSH, stopped the pulsatile release of LH and prevented follicular development beyond 2.5 mm diameter. There was no difference between the total number of follicles greater than 1.0 mm diameter present in the ovaries of GnRH agonist-treated ewes and day 8 luteal phase control ewes. During the sixth week of agonist treatment ewes were infused with ovine FSH (6 micrograms NIADDK-oFSH-16/h) in the presence of only basal concentrations of LH. After 24, 48, 72 or 120 h of FSH infusion, the mean number of follicles greater than 1.0 mm diameters per ewe was not significantly different between treated and control animals. Infusion of FSH caused a time-dependent increase in (1) the number of follicles per ovary greater than 2.5 mm, (2) the mean diameter of these follicles and (3) the proportion of the large follicles which could be classified as oestrogenic (greater than 3.7 nmol oestradiol/follicle per h in vitro). Injection of human chorionic gonadotrophin (750 IU i.m.) after 120 h of FSH infusion caused the majority of these large follicles to ovulate and form apparently normal corpora lutea. These results indicate that, in the absence of pulsatile LH, FSH stimulates the growth of normal large oestrogenic follicles which, when stimulated, ovulate to produce viable corpora lutea. MenosAbstract: The study investigated the relationship between the plasma concentration of FSH and the stimulation of preovulatory follicle growth in vivo in ewes chronically treated with the gonadotrophin-releasing hormone (GnRH) agonist buserelin (HOE 766). Welsh Mountain ewes with regular oestrous cycles were treated for 6 weeks with two discs implants placed s.c., each containing 5 mg of the agonist in a matrix of polyhydroxybutyric acid. Treatment with the agonist for 35 days produced a sustained suppression of the plasma concentration of FSH, stopped the pulsatile release of LH and prevented follicular development beyond 2.5 mm diameter. There was no difference between the total number of follicles greater than 1.0 mm diameter present in the ovaries of GnRH agonist-treated ewes and day 8 luteal phase control ewes. During the sixth week of agonist treatment ewes were infused with ovine FSH (6 micrograms NIADDK-oFSH-16/h) in the presence of only basal concentrations of LH. After 24, 48, 72 or 120 h of FSH infusion, the mean number of follicles greater than 1.0 mm diameters per ewe was not significantly different between treated and control animals. Infusion of FSH caused a time-dependent increase in (1) the number of follicles per ovary greater than 2.5 mm, (2) the mean diameter of these follicles and (3) the proportion of the large follicles which could be classified as oestrogenic (greater than 3.7 nmol oestradiol/follicle per h in vitro). Injection of human chorionic gonad... Mostrar Tudo |
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Palavras-Chave: |
Buserelin; Drug effects; FSH; LH; Time Factors. |
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Thesaurus Nal: |
Ewes; Ovarian follicles; Pharmacology; Physiology; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02670naa a2200277 a 4500
001 2071394
005 2017-06-23
008 1990 bl uuuu u00u1 u #d
024 7 $a10.1677/joe.0.1260297$2DOI
100 1 $aPICTON, H. M.
245 $aFSH causes a time-dependent stimulation of preovulatory follicle growth in the absence of pulsatile LH secretion in ewes chronically treated with gonadotrophin-releasing hormone agonist.
260 $c1990
520 $aAbstract: The study investigated the relationship between the plasma concentration of FSH and the stimulation of preovulatory follicle growth in vivo in ewes chronically treated with the gonadotrophin-releasing hormone (GnRH) agonist buserelin (HOE 766). Welsh Mountain ewes with regular oestrous cycles were treated for 6 weeks with two discs implants placed s.c., each containing 5 mg of the agonist in a matrix of polyhydroxybutyric acid. Treatment with the agonist for 35 days produced a sustained suppression of the plasma concentration of FSH, stopped the pulsatile release of LH and prevented follicular development beyond 2.5 mm diameter. There was no difference between the total number of follicles greater than 1.0 mm diameter present in the ovaries of GnRH agonist-treated ewes and day 8 luteal phase control ewes. During the sixth week of agonist treatment ewes were infused with ovine FSH (6 micrograms NIADDK-oFSH-16/h) in the presence of only basal concentrations of LH. After 24, 48, 72 or 120 h of FSH infusion, the mean number of follicles greater than 1.0 mm diameters per ewe was not significantly different between treated and control animals. Infusion of FSH caused a time-dependent increase in (1) the number of follicles per ovary greater than 2.5 mm, (2) the mean diameter of these follicles and (3) the proportion of the large follicles which could be classified as oestrogenic (greater than 3.7 nmol oestradiol/follicle per h in vitro). Injection of human chorionic gonadotrophin (750 IU i.m.) after 120 h of FSH infusion caused the majority of these large follicles to ovulate and form apparently normal corpora lutea. These results indicate that, in the absence of pulsatile LH, FSH stimulates the growth of normal large oestrogenic follicles which, when stimulated, ovulate to produce viable corpora lutea.
650 $aEwes
650 $aOvarian follicles
650 $aPharmacology
650 $aPhysiology
650 $aSheep
653 $aBuserelin
653 $aDrug effects
653 $aFSH
653 $aLH
653 $aTime Factors
700 1 $aTSONIS, C. G.
700 1 $aMCNEILLY, A. S.
773 $tJournal of Endocrinology$gv. 126, n. 2, p. 297-307, Aug. 1990.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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| Registros recuperados : 6 | |
| 4. |  | SOUZA, C. J. H. de; McNEILLY, A. S.; BENAVIDES, M. V.; MELO, E. O.; MORAES, J. C. F. Mutation in the protease cleavage site of GDF9 increases ovulation rate and litter size in heterozygous ewes and causes infertility in homozygous ewes. Animal Genetics, Oxford, v. 45, n. 5, p. 732-739, Oct. 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pecuária Sul; Embrapa Pesca e Aquicultura; Embrapa Recursos Genéticos e Biotecnologia. |
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| 5. | | SOUZA, C. J. H. de; MCNEILLY, A. S.; BENAVIDES, M. V.; MELO, E. de O.; MORAES, J. C. F. Polimorfismo no gene GDF9 determinante de maior taxa de ovulação e prolificidade em ovinos. In: REUNIÓN DE LA ASOCIACIÓN LATINOAMERICANA DE PRODUCCIÓN ANIMAL, 22., 2011, Montevideo, Uruguay. Memorias... Montevideo: Asociación Uruguaya de Producción Animal, 2011. Poster.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 6. | | SOUZA, C. J. H. de; MCNEILLY, A. S.; BENAVIDES, M. V.; MELO, E. de O.; MORAES, J. C. F. Polimorfismo no gene GDF9 determinante de maior taxa de ovulação e prolificidade em ovinos. In: REUNIÓN DE LA ASOCIACIÓN LATINOAMERICANA DE PRODUCCIÓN ANIMAL, 22., 2011, Montevideo, Uruguay. Memorias... Montevideo: Asociación Uruguaya de Producción Animal, 2011. 1 CD-ROM.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
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| Registros recuperados : 6 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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