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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Gado de Leite; Embrapa Pecuária Sudeste. |
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Data corrente: |
23/08/2017 |
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Data da última atualização: |
01/02/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BUZANSKAS, M. E.; GROSSI, D. do A.; VENTURA, R. V.; SCHENKEL, F. S.; CHUD, T. C. S.; STAFUZZA, N. B.; ROLA, L. D.; MEIRELLES, S. L. C.; MOKRY, F. B.; MUDADU, M. de A.; HIGA, R. H.; SILVA, M. V. G. B.; ALENCAR, M. M. de; REGITANO, L. C. de A.; MUNARI, D. P. |
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Afiliação: |
MARCOS ELI BUZANSKAS, UFPB; DANIELA DO AMARAL GROSSI, Fast Genetics, Saskatoon; RICARDO VIEIRA VENTURA, Beef Improvement Opportunities, Guelph; FLAVIO SCHRAMM SCHENKEL, University of Guelph; TATIANE CRISTINA SELEGUIM CHUD, FCAV/Unesp; NEDENIA BONVINO STAFUZZA, FCAV/Unesp; LUCIANA DINIZ ROLA, FCAV/Unesp; SARAH LAGUNA CONCEIÇÃO MEIRELLES, Ufla; FABIANA BARICHELLO MOKRY, UFSCar; MAURICIO DE ALVARENGA MUDADU, CNPTIA; ROBERTO HIROSHI HIGA, CNPTIA; MARCOS VINICIUS GUALBERTO B SILVA, CNPGL; MAURICIO MELLO DE ALENCAR, CPPSE; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; DANÍSIO PRADO MUNARI, FCAV/Unesp. |
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Título: |
Candidate genes for male and female reproductive traits in Canchim beef cattle. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
Journal of Animal Science and Biotechnology, v. 8, p. 1-10, 2017. |
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DOI: |
10.1186/s40104-017-0199-8 |
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Idioma: |
Inglês |
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Notas: |
Artigo 67. Na publicação: Marcos Vinícius Gualberto Barbosa da Silva. |
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Conteúdo: |
Background: Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 animals. Results: Associated SNPs were observed for scrotal circumference at 420 d of age (435 SNPs), followed by scrotal circumference at 210 d of age (12 SNPs), age at first calving (six SNPs), and age at second calving (four SNPs). We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and reproduction. Conclusions: Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless, the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, all relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program. MenosBackground: Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 animals. Results: Associated SNPs were observed for scrotal circumference at 420 d of age (435 SNPs), followed by scrotal circumference at 210 d of age (12 SNPs), age at first calving (six SNPs), and age at second calving (four SNPs). We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and reproduction. Conclusions: Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless, the high linkage d... Mostrar Tudo |
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Palavras-Chave: |
Polimorfismo de nucleotídeo único. |
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Thesagro: |
Gado Canchim; Gado de corte. |
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Thesaurus Nal: |
Beef cattle; Genome-wide association study; Quantitative trait loci; Single nucleotide polymorphism. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/162973/1/AP-Candidate-genes-Buzanskas-etal.pdf
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Marc: |
LEADER 03090naa a2200397 a 4500
001 2074373
005 2018-02-01
008 2017 bl uuuu u00u1 u #d
024 7 $a10.1186/s40104-017-0199-8$2DOI
100 1 $aBUZANSKAS, M. E.
245 $aCandidate genes for male and female reproductive traits in Canchim beef cattle.$h[electronic resource]
260 $c2017
500 $aArtigo 67. Na publicação: Marcos Vinícius Gualberto Barbosa da Silva.
520 $aBackground: Beef cattle breeding programs in Brazil have placed greater emphasis on the genomic study of reproductive traits of males and females due to their economic importance. In this study, genome-wide associations were assessed for scrotal circumference at 210 d of age, scrotal circumference at 420 d of age, age at first calving, and age at second calving, in Canchim beef cattle. Data quality control was conducted resulting in 672,778 SNPs and 392 animals. Results: Associated SNPs were observed for scrotal circumference at 420 d of age (435 SNPs), followed by scrotal circumference at 210 d of age (12 SNPs), age at first calving (six SNPs), and age at second calving (four SNPs). We investigated whether significant SNPs were within genic or surrounding regions. Biological processes of genes were associated with immune system, multicellular organismal process, response to stimulus, apoptotic process, cellular component organization or biogenesis, biological adhesion, and reproduction. Conclusions: Few associations were observed for scrotal circumference at 210 d of age, age at first calving, and age at second calving, reinforcing their polygenic inheritance and the complexity of understanding the genetic architecture of reproductive traits. Finding many associations for scrotal circumference at 420 d of age in various regions of the Canchim genome also reveals the difficulty of targeting specific candidate genes that could act on fertility; nonetheless, the high linkage disequilibrium between loci herein estimated could aid to overcome this issue. Therefore, all relevant information about genomic regions influencing reproductive traits may contribute to target candidate genes for further investigation of causal mutations and aid in future genomic studies in Canchim cattle to improve the breeding program.
650 $aBeef cattle
650 $aGenome-wide association study
650 $aQuantitative trait loci
650 $aSingle nucleotide polymorphism
650 $aGado Canchim
650 $aGado de corte
653 $aPolimorfismo de nucleotídeo único
700 1 $aGROSSI, D. do A.
700 1 $aVENTURA, R. V.
700 1 $aSCHENKEL, F. S.
700 1 $aCHUD, T. C. S.
700 1 $aSTAFUZZA, N. B.
700 1 $aROLA, L. D.
700 1 $aMEIRELLES, S. L. C.
700 1 $aMOKRY, F. B.
700 1 $aMUDADU, M. de A.
700 1 $aHIGA, R. H.
700 1 $aSILVA, M. V. G. B.
700 1 $aALENCAR, M. M. de
700 1 $aREGITANO, L. C. de A.
700 1 $aMUNARI, D. P.
773 $tJournal of Animal Science and Biotechnology$gv. 8, p. 1-10, 2017.
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Embrapa Agricultura Digital (CNPTIA) |
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