Data/hora: 23/09/2024 12:18:01

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	10/09/2018	
Data da última atualização: 	10/09/2018	
Autoria: 	MANTLE, P. G.; MORTIMER, P. H.; WHITE, E. P.	
Título: 	Mycotoxic tremorgens of Claviceps paspali and Penicillium cyclopium: a comparative study of effects on sheep and cattle in relation to natural staggers syndromes.	
Ano de publicação: 	1978	
Fonte/Imprenta: 	Research in Veterinary Science, v. 24, n. 1, p. 49-56, Jan. 1978.	
Idioma: 	Inglês	
Conteúdo: 	Abstract: Claviceps paspali sclerotia were dosed orally at various levels to sheep and cattle and the neurotoxic effects are described. Evidence is presented which indicates that the tremors are produced by a neutral tremorgen fraction. The ergot alkaloids, principally D-lysergic acid alpha-hydroxyethylamide and its isolysergic acid isomer, are not involved. The mixture of C paspali tremorgens has not been separated and characterised but its components are chemically related to other known tremorgens, such as penitrem A, produced by saprophytic moulds, notably Penicillium cyclopium. P cyclopium mycelium and C paspali sclerotia were dosed to produce comparable effects in sheep and in cattle. Similarly, effects of penitrem A and tremorgen concentrate of C paspali were compared after intravenous dosage to sheep. Observed enurotoxic effects of both moulds were identical in most respects. A low level of tremorgenic activity was detected at the honeydew stage of C paspali. These findings are discussed in relation to staggers syndromes occurring in grazing livestock.	
Palavras-Chave: 	Chemically induced; Tremor.	
Thesaurus Nal: 	Claviceps; Dosage; Intravenous injection; Mycotoxins; Oral administration; Sheep diseases; Toxicity.	
Categoria do assunto: 	H Saúde e Patologia	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (37546-1) - ADD - AP - PP -  -  -  - DIS