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Registro Completo |
Biblioteca(s): |
Ebooks. |
Data corrente: |
01/02/2013 |
Data da última atualização: |
01/02/2013 |
Autoria: |
MORRÉ, D. J.; MOLLENHAUER, H. H. |
Afiliação: |
D. James Morré; Hilton H. Mollenhauer. |
Título: |
The Golgi Apparatus: The First 100 Years. |
Ano de publicação: |
2009 |
Fonte/Imprenta: |
Springer eBooks. |
Descrição Física: |
digital. |
ISBN: |
9780387743479 |
DOI: |
10.1007/978-0-387-74347-9 |
Idioma: |
Inglês |
Conteúdo: |
History of the Golgi Apparatus -- Morphology of the Golgi Apparatus (Architecture/Structure) -- Isolation and Subfractionation -- Golgi Apparatus Tubules -- Golgi Apparatus and Membrane Biogenesis -- Golgi Apparatus Function in the Flow-Differentiation of Membranes -- Biochemistry of the Golgi Apparatus -- Golgi Apparatus Function in Secretion -- Golgi Apparatus Replication -- Cell Free Systems for Study of Golgi Apparatus Function -- Golgi Apparatus Function in Growth and Cell Enlargement -- The Golgi Apparatus and Cancer -- The Golgi Apparatus: A Look Ahead. .The Golgi apparatus (GA) found as a ubiquitous component of all eukaryotic cells is typically comprised of stacks of 3 to 7 or more saccules called cisternae that consist of a lumen or central cavity surrounded by a membrane. At the peripheries of the saccules may be found perforations about 600 nM in diameter known as fenestrate. Such fenestrated margins are usually continuous with a system of vesicles and tubules. The individual stacks are organized into larger aggregate GA structures either side-by-side to form a complex ribbon with stacks interconnected by the peripheral tubules or in a dispersed arrangement with the stacks widely separated to appear almost as discrete units within the cytoplasm. The Golgi apparatus is often considered as the "distribution and shipping department" for the cell but also plays an equally important role in cell growth and membrane biogenesis. It modifies proteins and lipids (fats) to prepare them for export outside the cell or for delivery to the plasma membrane in support of membrane growth and replacement of membrane constituents lost due to turnover. The Golgi Apparatus traces the first 100 years of GA discovery from the first published accounts from Pavia, Italy, in 1898 to the Centenary Celebration in Pavia, Italy, in 1998 to our most recent discoveries. It summarizes the past 50 years beginning with the modern era of GA discovery initiated in 1954 and made possible by the advent of the electron microscope, methods of cell fractionation and biochemical analysis, leading up to the present era where focus has been on molecular biology. Emphasized are organization and function, the existence and importance of cisternal tubules, development of methods of GA isolation and subfractionation, biochemical analyses of highly purified GA fractions and comparison to equally highly purified reference fractions and their use in cell free systems analysis of membrane trafficking, the concept of GA function as part of an integrated system of internal endomembranes (the endomembrane system), evidence for differentiation of membranes across the stacks of GA cisternae, and flux of membrane constituents along the polarity gradient defined by membrane differentiation all culminating in the membrane maturation or flow differentiation model of GA function. More recent contributions to GA in cell growth (enlargement) and to cancer are summarized in final chapters. MenosHistory of the Golgi Apparatus -- Morphology of the Golgi Apparatus (Architecture/Structure) -- Isolation and Subfractionation -- Golgi Apparatus Tubules -- Golgi Apparatus and Membrane Biogenesis -- Golgi Apparatus Function in the Flow-Differentiation of Membranes -- Biochemistry of the Golgi Apparatus -- Golgi Apparatus Function in Secretion -- Golgi Apparatus Replication -- Cell Free Systems for Study of Golgi Apparatus Function -- Golgi Apparatus Function in Growth and Cell Enlargement -- The Golgi Apparatus and Cancer -- The Golgi Apparatus: A Look Ahead. .The Golgi apparatus (GA) found as a ubiquitous component of all eukaryotic cells is typically comprised of stacks of 3 to 7 or more saccules called cisternae that consist of a lumen or central cavity surrounded by a membrane. At the peripheries of the saccules may be found perforations about 600 nM in diameter known as fenestrate. Such fenestrated margins are usually continuous with a system of vesicles and tubules. The individual stacks are organized into larger aggregate GA structures either side-by-side to form a complex ribbon with stacks interconnected by the peripheral tubules or in a dispersed arrangement with the stacks widely separated to appear almost as discrete units within the cytoplasm. The Golgi apparatus is often considered as the "distribution and shipping department" for the cell but also plays an equally important role in cell growth and membrane biogenesis. It modifies proteins and lipids ... Mostrar Tudo |
Palavras-Chave: |
Biochemistry, general; Biological Microscopy; Cancer Research; Cytology; Life Sciences; Neurosciences; Oncology. |
Thesaurus Nal: |
biochemistry; cell biology; microscopy; plant biochemistry. |
Categoria do assunto: |
-- |
URL: |
https://dx.doi.org/10.1007/978-0-387-74347-9
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Marc: |
LEADER 03798nam a2200289 a 4500 001 1947218 005 2013-02-01 008 2009 bl uuuu 00u1 u #d 020 $a9780387743479 024 7 $a10.1007/978-0-387-74347-9$2DOI 100 1 $aMORRÉ, D. J. 245 $aThe Golgi Apparatus$bThe First 100 Years.$h[electronic resource] 260 $aSpringer eBooks.$c2009 300 $cdigital. 520 $a<P>History of the Golgi Apparatus -- Morphology of the Golgi Apparatus (Architecture/Structure) -- Isolation and Subfractionation -- Golgi Apparatus Tubules -- Golgi Apparatus and Membrane Biogenesis -- Golgi Apparatus Function in the Flow-Differentiation of Membranes -- Biochemistry of the Golgi Apparatus -- Golgi Apparatus Function in Secretion -- Golgi Apparatus Replication -- Cell Free Systems for Study of Golgi Apparatus Function -- Golgi Apparatus Function in Growth and Cell Enlargement -- The Golgi Apparatus and Cancer -- The Golgi Apparatus: A Look Ahead.</P>.<P>The Golgi apparatus (GA) found as a ubiquitous component of all eukaryotic cells is typically comprised of stacks of 3 to 7 or more saccules called cisternae that consist of a lumen or central cavity surrounded by a membrane. At the peripheries of the saccules may be found perforations about 600 nM in diameter known as fenestrate. Such fenestrated margins are usually continuous with a system of vesicles and tubules. The individual stacks are organized into larger aggregate GA structures either side-by-side to form a complex ribbon with stacks interconnected by the peripheral tubules or in a dispersed arrangement with the stacks widely separated to appear almost as discrete units within the cytoplasm. The Golgi apparatus is often considered as the "distribution and shipping department" for the cell but also plays an equally important role in cell growth and membrane biogenesis. It modifies proteins and lipids (fats) to prepare them for export outside the cell or for delivery to the plasma membrane in support of membrane growth and replacement of membrane constituents lost due to turnover.</P> <P>The Golgi Apparatus traces the first 100 years of GA discovery from the first published accounts from Pavia, Italy, in 1898 to the Centenary Celebration in Pavia, Italy, in 1998 to our most recent discoveries. It summarizes the past 50 years beginning with the modern era of GA discovery initiated in 1954 and made possible by the advent of the electron microscope, methods of cell fractionation and biochemical analysis, leading up to the present era where focus has been on molecular biology. Emphasized are organization and function, the existence and importance of cisternal tubules, development of methods of GA isolation and subfractionation, biochemical analyses of highly purified GA fractions and comparison to equally highly purified reference fractions and their use in cell free systems analysis of membrane trafficking, the concept of GA function as part of an integrated system of internal endomembranes (the endomembrane system), evidence for differentiation of membranes across the stacks of GA cisternae, and flux of membrane constituents along the polarity gradient defined by membrane differentiation all culminating in the membrane maturation or flow differentiation model of GA function. More recent contributions to GA in cell growth (enlargement) and to cancer are summarized in final chapters.</P> 650 $abiochemistry 650 $acell biology 650 $amicroscopy 650 $aplant biochemistry 653 $aBiochemistry, general 653 $aBiological Microscopy 653 $aCancer Research 653 $aCytology 653 $aLife Sciences 653 $aNeurosciences 653 $aOncology 700 1 $aMOLLENHAUER, H. H.
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Registros recuperados : 109 | |
7. | | RIBEIRO, S. S.; CARVALHO, H. W. L. de; FUKUDA, W. M. G.; OLIVEIRA, I. R. de; OLIVEIRA, V. D. de. Avaliação de cultivares de mandioca para consumo humano na zona centro-sul do Estado de Sergipe. In: CONGRESSO BRASILEIRO DA MANDIOCA, 12., 2007, Paranavaí. Mandioca: bioenergia, alimento e renda. Botucatu: CERAT- UNESP, [2007].Tipo: Artigo em Anais de Congresso / Nota Técnica |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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9. | | OLIVEIRA, V. D. de; CARVALHO, H. W. L. de; FUKUDA, W. M. G.; OLIVEIRA, I. R. de; RIBEIRO, S. S. Avaliação de cultivares de mandioca na zona agreste de Sergipe. In: CONGRESSO BRASILEIRO DA MANDIOCA, 12., 2007, Paranavaí. Mandioca: bioenergia, alimento e renda. Botucatu: CERAT- UNESP, [2007].Tipo: Artigo em Anais de Congresso / Nota Técnica |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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12. | | MELO, K. E. de O.; OLIVEIRA, V. D. de; FEITOSA, L. F.; CARVALHO, H. W. L. de C. Avaliação de variedades de mandioca para consumo humano. In: ENCONTRO DE INICIAÇÃO CIENTÍFICA, 17., ENCONTRO DE PÓS-GRADUAÇÃO, 3., 2007, São Cristóvão. Anais... São Cristovão: Universidade Federal de Sergipe, 2007. 1 CD-ROM.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Tabuleiros Costeiros. |
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15. | | CARVALHO, H. W. L. de; FUKUDA, W. M. G.; OLIVEIRA, I. R. de; OLIVEIRA, V. D. DE; RIBEIRO, S. S. Comportamento de cultivares de mandioca brava na microrregião do agreste de Lagarto-SE. In: CONGRESSO BRASILEIRO DA MANDIOCA, 12., 2007, Paranavaí. Mandioca: bioenergia, alimento e renda. Botucatu: CERAT- UNESP, [2007].Tipo: Artigo em Anais de Congresso / Nota Técnica |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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17. | | OLIVEIRA, V. D. de; CARVALHO, H. W. L. de; FUKUDA, W. M. G.; OLIVEIRA, I. R. de; RIBEIRO, S. S. Desempenho de cultivares de mandioca na zona centro-sul do Estado de Sergipe. In: CONGRESSO BRASILEIRO DA MANDIOCA, 12., 2007, Paranavaí. Mandioca: bioenergia, alimento e renda. Botucatu: CERAT- UNESP, [2007].Tipo: Artigo em Anais de Congresso / Nota Técnica |
Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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18. | | CARVALHO, H. W. L. de; PACHECO, C. A. P.; RODRIGUES, A. R. S.; RIBEIRO, S. S.; OLIVEIRA, V. D. de. Estimativas dos parâmetros genéticos nas populações CPATC-5 e CPATC-6. In: CONGRESSO NACIONAL DE MILHO E SORGO, 26.; SIMPÓSIO BRASILEIRO SOBRE A LAGARTA-DO-CARTUCHO, SPODOPTERA FRUGIPERDA, 2.; SIMPÓSIO SOBRE COLLETOTRICHUM GRAMINICOLA, 1., 2006, Belo Horizonte. Inovação para sistemas integrados de produção: trabalhos apresentados. [Sete Lagoas]: ABMS, 2006. 1 CD-ROM.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Milho e Sorgo. |
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