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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
15/01/2008 |
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Data da última atualização: |
25/03/2014 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, V. L. S. S. de; MELLO, M. A. de; DINIZ, C. A. R.; MORITA, L. H. M.; ZUCCHI, T.; POLI, P. |
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Afiliação: |
Vera Lúcia Scherholz Salgado de Castro, Embrapa Meio Ambiente; Michele A. de Melo, Departamento de Parasitologia-ICB-USP; Carlos Diniz, UFSCAR; Lia Morita, UFSCAR; Tânia Zucchi, Departamento de Parasitologia-ICB-USP; Paola Poli, Departamento de Parasitologia-ICB-USP. |
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Título: |
Neurodevelopmental effects of perinatal fenarimol exposure on rats. |
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Ano de publicação: |
2007 |
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Fonte/Imprenta: |
Reproductive Toxicology, Elmsford, v. 23, n. 1, p. 98-105, 2007. |
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Idioma: |
Inglês |
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Conteúdo: |
Knowledge about the potential toxic effects of fenarimol, a widely used fungicide, is still limited. Fenarimol is an aromatase inhibitor and therefore can affect estrogen/androgen levels in vivo in rodents. In view of these facts, the aim of the present work was to study the effects of fenarimol maternal exposure during different critical phases in the development of central nervous system in rat pups, on early physical and neurobehavioral endpoints essential to their development. For that, the effects of the fungicide fenarimol (150 and 300 mg/kg) were examined at three different developmental stages in the rat: during the first 6 days of gestation, prenatal (15-21 days), or first 6 days of lactation. Three categories of the impact of fenarimol on neonatal growth and neurobehavioral development of offspring were assessed: (1) physical, (2) reflex and strength, and (3) motor coordination. Findings on the pups? physical development did not indicate any significant alterations of the postnatal age at which specific developmental milestones were observed (pinna detachment, development of the fur, eruption of the incisor teeth, opening of the ears and eyes and testes descent). However, there was a reduced rate of weight gain in pups of mothers treated during lactation related to the earlier testing time periods (1-23 days of life). The study of the functional state of the rat pup nervous systems at different stages of postnatal development revealed some neurodevelopmental delays in righting reflex, climbing and grip response and locomotion (20-90 days of life) in the treated groups. Taken together, findings of this study emphasize that, as a result of fenarimol maternal exposure, some neuromuscular and behavioral deficits in nursing pups may occur principally during the last gestational period and lactation. These results could be the basis for further studies on molecular actions of fenarimol in order to predict better the biological consequences of this fungicide. MenosKnowledge about the potential toxic effects of fenarimol, a widely used fungicide, is still limited. Fenarimol is an aromatase inhibitor and therefore can affect estrogen/androgen levels in vivo in rodents. In view of these facts, the aim of the present work was to study the effects of fenarimol maternal exposure during different critical phases in the development of central nervous system in rat pups, on early physical and neurobehavioral endpoints essential to their development. For that, the effects of the fungicide fenarimol (150 and 300 mg/kg) were examined at three different developmental stages in the rat: during the first 6 days of gestation, prenatal (15-21 days), or first 6 days of lactation. Three categories of the impact of fenarimol on neonatal growth and neurobehavioral development of offspring were assessed: (1) physical, (2) reflex and strength, and (3) motor coordination. Findings on the pups? physical development did not indicate any significant alterations of the postnatal age at which specific developmental milestones were observed (pinna detachment, development of the fur, eruption of the incisor teeth, opening of the ears and eyes and testes descent). However, there was a reduced rate of weight gain in pups of mothers treated during lactation related to the earlier testing time periods (1-23 days of life). The study of the functional state of the rat pup nervous systems at different stages of postnatal development revealed some neurodevelopmental delays... Mostrar Tudo |
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Palavras-Chave: |
Coordenação motora; Desenvolvimento neurocomportamental; Sistema nervoso central; Teste. |
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Thesagro: |
Fungicida; Toxicologia; Toxidez. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02738naa a2200265 a 4500
001 1015999
005 2014-03-25
008 2007 bl uuuu u00u1 u #d
100 1 $aCASTRO, V. L. S. S. de
245 $aNeurodevelopmental effects of perinatal fenarimol exposure on rats.
260 $c2007
520 $aKnowledge about the potential toxic effects of fenarimol, a widely used fungicide, is still limited. Fenarimol is an aromatase inhibitor and therefore can affect estrogen/androgen levels in vivo in rodents. In view of these facts, the aim of the present work was to study the effects of fenarimol maternal exposure during different critical phases in the development of central nervous system in rat pups, on early physical and neurobehavioral endpoints essential to their development. For that, the effects of the fungicide fenarimol (150 and 300 mg/kg) were examined at three different developmental stages in the rat: during the first 6 days of gestation, prenatal (15-21 days), or first 6 days of lactation. Three categories of the impact of fenarimol on neonatal growth and neurobehavioral development of offspring were assessed: (1) physical, (2) reflex and strength, and (3) motor coordination. Findings on the pups? physical development did not indicate any significant alterations of the postnatal age at which specific developmental milestones were observed (pinna detachment, development of the fur, eruption of the incisor teeth, opening of the ears and eyes and testes descent). However, there was a reduced rate of weight gain in pups of mothers treated during lactation related to the earlier testing time periods (1-23 days of life). The study of the functional state of the rat pup nervous systems at different stages of postnatal development revealed some neurodevelopmental delays in righting reflex, climbing and grip response and locomotion (20-90 days of life) in the treated groups. Taken together, findings of this study emphasize that, as a result of fenarimol maternal exposure, some neuromuscular and behavioral deficits in nursing pups may occur principally during the last gestational period and lactation. These results could be the basis for further studies on molecular actions of fenarimol in order to predict better the biological consequences of this fungicide.
650 $aFungicida
650 $aToxicologia
650 $aToxidez
653 $aCoordenação motora
653 $aDesenvolvimento neurocomportamental
653 $aSistema nervoso central
653 $aTeste
700 1 $aMELLO, M. A. de
700 1 $aDINIZ, C. A. R.
700 1 $aMORITA, L. H. M.
700 1 $aZUCCHI, T.
700 1 $aPOLI, P.
773 $tReproductive Toxicology, Elmsford$gv. 23, n. 1, p. 98-105, 2007.
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| Registros recuperados : 5 | |
| 3. |  | MORITA, L. H. M.; DINIZ, C. A. R.; CASTRO, V. L. S. S. de. Estudo do reflexo de subir como parâmetro do desenvolvimento físico de filhotes expostos perinatalmente ao fungicida fenarimol. In: REUNIÃO ANUAL DA REGIÃO BRASILEIRA DA SOCIEDADE INTERNACIONAL DE BIOMETRIA, 50., SIMPÓSIO DE ESTATÍTSTICA APLICADA À EXXPERIMENTAÇÃO AGRONÔMICA, 11., 2005, Londrina/PR. [Anais...] Londrina/PR: RBRAS, SEAGRO, 2005. p. 1-5.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Meio Ambiente. |
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| 4. | | MORITA, L. H. M.; DINIZ, C. A. R.; CASTRO, V. L. S. S. de. Estudo do reflexo de subir como parâmetro do desenvolvimento físico de filhotes expostos perinatalmente ao fungicida fenarimol. In: REUNIÃO ANUAL DA REGIÃO BRASILEIRA DA SOCIEDADE INTERNACIONAL DE BIOMETRIA, 50., SIMPÓSIO DE ESTATÍTSTICA APLICADA À EXPERIMENTAÇÃO AGRONÔMICA, 11., 2005, Londrina/PR. Programa e resumos. Londrina/PR: RBRAS, SEAGRO, 2005. p.151.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Meio Ambiente. |
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| 5. | | CASTRO, V. L. S. S. de; MELLO, M. A. de; DINIZ, C. A. R.; MORITA, L. H. M.; ZUCCHI, T.; POLI, P. Neurodevelopmental effects of perinatal fenarimol exposure on rats. Reproductive Toxicology, Elmsford, v. 23, n. 1, p. 98-105, 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Meio Ambiente. |
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| Registros recuperados : 5 | |
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