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 | Acesso ao texto completo restrito à biblioteca da Embrapa Amazônia Ocidental. Para informações adicionais entre em contato com cpaa.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Amazônia Ocidental. |
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Data corrente: |
19/09/2006 |
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Data da última atualização: |
06/01/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FUKUMASU, H.; AVANZO, J. L.; HEIDOR, R.; SILVA, T. C.; ATROCH, A.; MORENO, F. S.; DAGLI, M. L. Z. |
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Afiliação: |
H. Fukumasu, USP; J.L. Avanzo, USP; R. Heidor, USP; T.C. Silva, USP; André Atroch, CPAA; F.S. Moreno, USP; M.L.Z. Dagli, USP. |
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Título: |
Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. |
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Ano de publicação: |
2006 |
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Fonte/Imprenta: |
Food and Chemical Toxicology, v. 44, n. 6 , p. 862-867, jun. 2006. |
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Idioma: |
Inglês |
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Conteúdo: |
Guarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver. |
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Thesagro: |
DNA; Guaraná; Paullinia Cupana. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01880naa a2200229 a 4500
001 1678895
005 2015-01-06
008 2006 bl uuuu u00u1 u #d
100 1 $aFUKUMASU, H.
245 $aProtective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver.
260 $c2006
520 $aGuarana (Paullinia cupana Mart. var. Sorbilis) is a plant originally from Brazil, which is rich in tannins. Some tannins are known to present protective effects against DNA damage. This study was performed to investigate the anti-genotoxic/cytotoxic properties of guarana in hepatocytes of mice injected with N-nitrosodiethylamine (DEN). The protective effect of guarana was evaluated both by comet assay and DNA smear fragmentation technique in two month-old female BALB/c mice. These were treated previously with 2.0 mg/g bw of guarana for 16 days and then injected with DEN (160 µg/g body weight) to induce DNA damage. The DEN-only treated group presented higher comet image length than the guarana plus DEN and untreated groups (116.06 ± 5.0 µm, 104.09 ± 3.3 µm and 93.28 ± 14.4 µm, respectively; p < 0.01). Guarana treatment presented a 52.54% reduction in comet image length when animals were exposed to DEN (p < 0.05). DNA samples from the guarana plus DEN group clearly showed less EtBr fluorescence intensity when compared to the DEN-only group, reinforcing the comet assay data. These results show, for the first time, that guarana has a protective effect against DEN-induced DNA damage in mouse liver.
650 $aDNA
650 $aGuaraná
650 $aPaullinia Cupana
700 1 $aAVANZO, J. L.
700 1 $aHEIDOR, R.
700 1 $aSILVA, T. C.
700 1 $aATROCH, A.
700 1 $aMORENO, F. S.
700 1 $aDAGLI, M. L. Z.
773 $tFood and Chemical Toxicology$gv. 44, n. 6 , p. 862-867, jun. 2006.
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Registro original: |
Embrapa Amazônia Ocidental (CPAA) |
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| Registros recuperados : 2 | |
| 1. |  | FUKUMASU, H.; AVANZO, J. L.; HEIDOR, R.; SILVA, T. C.; ATROCH, A.; MORENO, F. S.; DAGLI, M. L. Z. Protective effects of guarana (Paullinia cupana Mart. var. Sorbilis) against DEN-induced DNA damage on mouse liver. Food and Chemical Toxicology, v. 44, n. 6 , p. 862-867, jun. 2006.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - A |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| 2. | | FUKUMASU, H.; SILVA, T. C. da; AVANZO, J. L.; LIMA, C. E. de; MACKOWIAK, I. I.; ATROCH, A.; SPINOSA, H. de S.; MORENO, F. S.; DAGLI, M. L. Z. Chemopreventive effects of Paullinia cupana Mart var. sorbilis, the guarana, on mouse hepatocarcinogenesis. Cancer Letters, v. 233, n. 1, p. 158-164, fev. 2006.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - C |
| Biblioteca(s): Embrapa Amazônia Ocidental. |
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| Registros recuperados : 2 | |
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