Data/hora: 21/06/2024 23:17:59

Biblioteca(s): 	Embrapa Instrumentação.	
Data corrente: 	20/06/2022	
Data da última atualização: 	20/06/2022	
Autoria: 	BORGES, F. A.; DRAGO, B. C.; BAGGIO, L. O.; BARROS, N. R. de; BRASIL, G. S. P.; SCONTRI, M.; MUSSAGY, C. U.; RIBEIRO, M. C. S.; MILORI, D. M. B. P.; MORAIS, C. P. de; MARANGONI, B. S.; NICOLODELLI, G.; MECWAN, M.; MANDAL, K.; GUERRA, N. B.; MENEGATTI, C. R.; HERCULANO, R. D.	
Afiliação: 	DEBORA MARCONDES BASTOS PEREIRA, CNPDIA.	
Título: 	Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	International Journal of Biological Macromolecules, v. 211, 2022.	
Páginas: 	568?579	
ISSN: 	0141-8130	
DOI: 	https://doi.org/10.1016/j.ijbiomac.2022.05.025	
Idioma: 	Inglês	
Conteúdo: 	Gold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV?Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 ± 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications	
Palavras-Chave: 	Gold nanoparticles; LIBS; Sustained release.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Instrumentação (CNPDIA)	
Exemplares: 	CNPDIA - (18033-1) - UPC - AP - DD - PROCI.22/75 -  - 2022/82 - DIS