Data/hora: 22/06/2024 00:35:21

Biblioteca(s): 	Embrapa Instrumentação.	
Data corrente: 	30/09/2022	
Data da última atualização: 	23/01/2024	
Autoria: 	SANTOS, D. M. dos; DIAS, L. M.; SURUR, A. K.; MORAES, D. A. de; PAVARINA, A. C.; FONTANA, C. R.; CORREA, D. S.	
Afiliação: 	DANIEL SOUZA CORREA, CNPDIA.	
Título: 	Electrospun composite bead-on-string nanofibers containing CaO2 nanoparticles and MnO2 nanosheets as oxygen-release systems for biomedical applications.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	ACS Applied Nano Materials, v. 5, 2022.	
Páginas: 	14425 - 14436	
ISSN: 	2574-0970	
DOI: 	https://doi.org/10.1021/acsanm.2c02774	
Idioma: 	Inglês	
Conteúdo: 	Oxygen-generating biomaterials have the potential to improve tissue engineering and regenerative therapeutic strategies. However, the development of such materials capable of controlling the local partial pressure of oxygen (pO2) in the long term is still a major challenge. Here we report nanostructured composite membranes comprising electrospun fibers exhibiting a bead-on-string structure as a controlled oxygen-release system for periodontitis treatment. For this, calcium peroxide nanoparticles (CaO2 NPs) and manganese dioxide nanosheets (MnO2 NSs) were incorporated into the structure of hydrophobic electrospun poly (lactic acid) (PLA)-based nanofibers. We use CaO2 NPs as hydrogen peroxide (H2O2)-generating precursors when exposed to water, while MnO2 NSs were applied as a nanozyme to catalyze the decomposition of H2O2 to the final oxygen product. Our results revealed that the beads on the fibrous structure acted as reservoirs of CaO2 NPs and MnO2 NSs. Moreover, the composite membranes provided sustained oxygen release over 7 days, where levels were modulated by the CaO2 NP content. Such constructs exhibited suitable physicochemical properties and antimicrobial activities against some bacteria (e.g., Porphyromonas gingivalis and Treponema denticola) typically associated with aggressive and chronic periodontitis. In vitro studies also revealed that the membranes were not cytotoxic toward human oral keratinocyte (Nok-si) cells as well as enhanced the cell viability when high content of CaO2 NP and MnO2 NS were incorporated into the fiber?s structure. Taken together, our results demonstrate that the nanostructured composite membranes show potential to be employed as oxygen-release platforms for periodontal tissue regeneration.	
Palavras-Chave: 	Bead-on-string fibers; Electrospinning; Oxygen generation; Periodontal regeneration.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Instrumentação (CNPDIA)	
Exemplares: 	CNPDIA - (18079-1) - UPC - AP - DD - PROCI.22/116 -  - 2022/116 - DIS