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Registro Completo |
Biblioteca(s): |
Embrapa Unidades Centrais. |
Data corrente: |
15/08/2016 |
Data da última atualização: |
15/08/2016 |
Autoria: |
ARGOLO NETO, N. M.; DEL CARLO, R. J.; MONTEIRO, B. S.; NARDI, N. B.; CHAGASTELLES, P. C.; BRITO, A. F. S.; REIS, A. M. S.; SILVA, L. M. C. |
Afiliação: |
NAPOLEÃO C. CHAGASTELLES, UFPI; RICARDO J. DEL CARLO, UFV; BETÂNEA S. MONTEIRO, UFV; NACE B. NARDI, ULBRA; PEDRO C. CHAGASTELLES, UFRGS; ANA FLORA S. BRITO, UFV; AMANDA M. S. REIS, UFV; LAÍS M. C. SILVA, UFPI. |
Título: |
Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice. |
Ano de publicação: |
2016 |
Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Brasília, DF, v.36, n. 7, p. 617-624, jul. 2016. |
Idioma: |
Inglês |
Conteúdo: |
Chronic cutaneous lesions affect 15% of diabetic human patients and represent a risk 15 to 46 times larger of limb amputations compared to people with normal glycemia. It is assumed that half of these amputations could be prevented by early treatment of wounds, for example, with proper cell therapy. Objectives: In this study, the action of the autologous transplant of mesenchymal stem-cells (MSC) was evaluated compared to the treatment with autologous platelet rich plasma (PRP) in the cicatrization of cutaneous lesions induced in diabetic mice. These animals were previously treated with streptozootocin to induce diabetes mellitus and round wounds of 1.5cm in diameter were created in the posterior region. Diameters of the wounds and healing time were evaluated during 30 days and the results were submitted to variance analysis and Tukey?s test average. It was noticed that the animals treated with MSC presented a more accelerated cicatrization of the cutaneous lesion than the animals treated with PRP. However, the treatment with PRP presented better results than just the daily asepsis of the lesions with saline or covering them with semi-permeable bandage. Besides, the use of semi-permeable bandage kept the cutaneous lesions of diabetic mice did not interfere negatively with cicatrization, proved to be harmless to use, but kept the cutaneous lesions more hydrated than the ones exposed to the environment. |
Palavras-Chave: |
Célula-troncos mesenquimais; Cicatrização da lesão; Cicatrization; Mesenchymal stem cells. |
Thesagro: |
Lesão cutânea. |
Thesaurus Nal: |
diabetes mellitus; Skin lesions; Tissue repair. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/146380/1/Role-of-the-autologous.pdf
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Marc: |
LEADER 02376naa a2200301 a 4500 001 2050889 005 2016-08-15 008 2016 bl uuuu u00u1 u #d 100 1 $aARGOLO NETO, N. M. 245 $aRole of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice. 260 $c2016 520 $aChronic cutaneous lesions affect 15% of diabetic human patients and represent a risk 15 to 46 times larger of limb amputations compared to people with normal glycemia. It is assumed that half of these amputations could be prevented by early treatment of wounds, for example, with proper cell therapy. Objectives: In this study, the action of the autologous transplant of mesenchymal stem-cells (MSC) was evaluated compared to the treatment with autologous platelet rich plasma (PRP) in the cicatrization of cutaneous lesions induced in diabetic mice. These animals were previously treated with streptozootocin to induce diabetes mellitus and round wounds of 1.5cm in diameter were created in the posterior region. Diameters of the wounds and healing time were evaluated during 30 days and the results were submitted to variance analysis and Tukey?s test average. It was noticed that the animals treated with MSC presented a more accelerated cicatrization of the cutaneous lesion than the animals treated with PRP. However, the treatment with PRP presented better results than just the daily asepsis of the lesions with saline or covering them with semi-permeable bandage. Besides, the use of semi-permeable bandage kept the cutaneous lesions of diabetic mice did not interfere negatively with cicatrization, proved to be harmless to use, but kept the cutaneous lesions more hydrated than the ones exposed to the environment. 650 $adiabetes mellitus 650 $aSkin lesions 650 $aTissue repair 650 $aLesão cutânea 653 $aCélula-troncos mesenquimais 653 $aCicatrização da lesão 653 $aCicatrization 653 $aMesenchymal stem cells 700 1 $aDEL CARLO, R. J. 700 1 $aMONTEIRO, B. S. 700 1 $aNARDI, N. B. 700 1 $aCHAGASTELLES, P. C. 700 1 $aBRITO, A. F. S. 700 1 $aREIS, A. M. S. 700 1 $aSILVA, L. M. C. 773 $tPesquisa Veterinária Brasileira, Brasília, DF$gv.36, n. 7, p. 617-624, jul. 2016.
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Embrapa Unidades Centrais (AI-SEDE) |
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Registros recuperados : 4 | |
1. | | OLIVEIRA, A. P. L.; RANGEL, J. P. P.; RAPOSO, V.; PIANCA, N. G.; CRUZ, E. P.; PEREIRA NETO, E.; FIORIO, W. A. B.; MONTEIRO, B. S. Allogenic mesenchymal stem cell intravenous infusion in reparation of mild intestinal ischemia/reperfusion injury in New Zealand rabbits. Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 38, n. 4, p. 710-721, abril 2018 Título em português: Infusão intravenosa de células tronco mesenquimais alógenas na reparação da lesão branda de isquemia/reperfusão intestinal em coelhos Nova Zelândia.Biblioteca(s): Embrapa Unidades Centrais. |
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2. | | BORGES, E. N.; ARAÚJO, C. de A.; MONTEIRO, B. S.; SILVA, A. S.; ALBUQUERQUE, L. de F.; ARAUJO, G. G. L. de; CAMPOS, F. S.; GOIS, G. C.; SOUZA, R. C. de; ARAÚJO, A. O. de. Buffel grass pre-dried as a modulator of the fermentation, nutritional and aerobic stability profile of cactus pear silage. New Zealand Journal of Agricultural Research, May, 2023. On line.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 3 |
Biblioteca(s): Embrapa Semiárido. |
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3. | | OLIVEIRA, A. P. L.; RANGEL, J. P. P.; RIODADES, L. F. S.; ALMEIDA, B. L.; MATHIAS, C. H. T.; CONTI, L. M. C.; FIORIO, W. A. B.; MONTEIRO, B. S. Establishment of an experimental model of small intestinal ischemia and reperfusion injuries in New Zealand rabbits. Pesquisa Veterinária Brasileira, Brasília, DF, v. 38, n 8, p. 1664-1674, agosto 2018 Título em português: Estabelecimento de modelo experimental de indução da lesão de isquemia e reperfusão de intestino delgado em coelhos Nova Zelândia.Biblioteca(s): Embrapa Unidades Centrais. |
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4. | | ARGOLO NETO, N. M.; DEL CARLO, R. J.; MONTEIRO, B. S.; NARDI, N. B.; CHAGASTELLES, P. C.; BRITO, A. F. S.; REIS, A. M. S.; SILVA, L. M. C. Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice. Pesquisa Veterinária Brasileira, Brasília, DF, v.36, n. 7, p. 617-624, jul. 2016.Biblioteca(s): Embrapa Unidades Centrais. |
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Registros recuperados : 4 | |
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