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Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
09/12/2021 |
Data da última atualização: |
09/12/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
LOPES, P. D.; OKINO, C. H.; FERNANDO, F. S.; PAVANI, C.; MARIGUELA, V. C.; MONTASSIER, M. DE F. S.; MONTASSIER, H. J. |
Afiliação: |
PRISCILA DINIZ LOPES, UNESP; CINTIA HIROMI OKINO, CPPSE; FILIPE SANTOS FERNANDO, UNESP; CAREN PAVANI, UNESP; VIVIANE CASAGRANDE MARIGUELA, UNESP; MARIA DE FÁTIMA SILVA MONTASSIER, UNESP; HÉLIO JOSÉ MONTASSIER, UNESP. |
Título: |
Comparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Vaccines, v.9, n.12, 1457, 2021. |
ISSN: |
2076-393X |
DOI: |
https://doi.org/10.3390/vaccines9121457 |
Idioma: |
Inglês |
Conteúdo: |
Efficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection. MenosEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vacci... Mostrar Tudo |
Palavras-Chave: |
Avian infectious bronchitis; Cellular immune response; Delivery carrier adjuvant; Mucosal immunization; Oil adjuvant. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/228815/1/ComparativeEvaluationImmune.pdf
|
Marc: |
LEADER 02553naa a2200277 a 4500 001 2137397 005 2021-12-09 008 2021 bl uuuu u00u1 u #d 022 $a2076-393X 024 7 $ahttps://doi.org/10.3390/vaccines9121457$2DOI 100 1 $aLOPES, P. D. 245 $aComparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens.$h[electronic resource] 260 $c2021 520 $aEfficient vaccines are the main strategy to control the avian coronavirus (AvCoV), although several drawbacks related to traditional attenuated and inactivated vaccines have been reported. These counterpoints highlight the importance of developing new alternative vaccines against AvCoV, especially those able to induce long-lasting immune responses. This study evaluated and compared two inactivated vaccines formulated with AvCoV BR-I variants, one composed of chitosan nanoparticles (AvCoV-CS) and the second by Montanide oily adjuvant (AvCoV-O). Both developed vaccines were administered in a single dose or associated with the traditional Mass attenuated vaccine. The AvCoV-CS vaccine administered alone or associated with the Mass vaccine was able to induce strong humoral and cell-mediated immune (CMI) responses and complete protection against IBV virulent infection, wherein single administration was characterized by high IgA antibody levels in the mucosa, whereas when associated with the Mass vaccine, the serum IgG antibody was predominantly observed. On the other hand, single administration of the oily vaccine presented poor humoral and CMI responses and consequently incomplete protection against virulent challenge, but when associated with the Mass vaccine, immune responses were developed, and complete protection against infection was observed. Both of our experimental vaccines were able to induce full protection against virulent IBV challenge. A single dose of AvCoV-CS vaccine was sufficient to achieve complete protection, while AvCoV-O required a previous priming by a Mass strain to complete the protection. 653 $aAvian infectious bronchitis 653 $aCellular immune response 653 $aDelivery carrier adjuvant 653 $aMucosal immunization 653 $aOil adjuvant 700 1 $aOKINO, C. H. 700 1 $aFERNANDO, F. S. 700 1 $aPAVANI, C. 700 1 $aMARIGUELA, V. C. 700 1 $aMONTASSIER, M. DE F. S. 700 1 $aMONTASSIER, H. J. 773 $tVaccines$gv.9, n.12, 1457, 2021.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Registros recuperados : 25 | |
3. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MONTASSIER, M. F. S.; BRENTANO, L.; RICHTZENHAIN, L. J.; OKINO, C. H.; MONTASSIER, H. J. Genetic diversity of partial S1 an N gene sequences of infectious bronckitis virus isolates from Brazil. Virus Reviews and Research, v. 15, supl. 1, p. 196, oct. 2010. Trabalho apresentado no NATIONAL MEETING OF VIROLOGY, 21.; MERCOSUL MEETING OF VIROLOGY, 5. Projeto/Plano de Ação: 03.09.01900-01.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
| ![Visualizar detalhes do registro](/consulta/web/img/visualizar.png) ![Imprime registro no formato completo](/consulta/web/img/print.png) |
4. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MONTASSIER, M. F. S.; BRENTANO, L.; RICHTZENHAIN, L. J.; MONTASSIER, H. J. Diversity in relevant epitopes of S1 glycoprotein and nucleocapsid (N) protein of Brazilian variants of infectious bronchitis virus. Virus Reviews and Research, v. 15, supl. 1, p. 196, oct. 2010. Trabalho apresentado no NATIONAL MEETING OF VIROLOGY, 21.; MERCOSUL MEETING OF VIROLOGY, 5. Projeto/Plano de Ação: 03.09.01900-01.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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6. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OKINO, C. H.; MONTASSIER, M. de F. S.; SILVA, K. R.; FERNANDO, F. S.; BRENTANO, L.; MONTASSIER, H. J. Avian infectious bronchitis vírus (IBV): effect of vaccine doses on mucosal imune responses and protection after challenge in chickens. In: WORLD´S POULTRY CONGRESS, 24., 2012, Salvador. Abstract... Salvador: WSPA, 2012. 1 CD-ROM. World's Poultry Science Journal, v. 68, supl. 1, 2012. Projeto/Plano de Ação: 05.11.11.002.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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7. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | SANTOS, I. L.; GIBERTONI, A. M.; MONTASSIER, M. de F. S.; OKINO, C. H.; MONTASSIER, H. J. Improvement of immunodiagnosis of avian infectious bronchitis virus (IBV) infection by the detection of IgM and IgG antibodies using a new recombinant nucleoprotein-based Elisa. In: WORLD´S POULTRY CONGRESS, 24., 2012, Salvador. Abstract... Salvador: WSPA, 2012. 1 CD-ROM. World's Poultry Science Journal, v. 68, supl. 1, 2012. Projeto/Plano de Ação: 05.11.11.002.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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8. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | SANTOS, I. L.; OKINO, C. H.; MONTASSIER, M. de F. S.; SILVA, K. R.; FERNANDO, F. S.; MONTASSIER, H. J. Immune-protection mechanisms against late challenge with avian infectious bronchitis vírus (IBV) induced by a single-dose of an attenuated vaccine in day-old chicks. In: WORLD´S POULTRY CONGRESS, 24., 2012, Salvador. Abstract... Salvador: WSPA, 2012. 1 CD-ROM. World's Poultry Science Journal, v. 68, supl. 1, 2012. Projeto/Plano de Ação: 05.11.11.002Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
| ![Visualizar detalhes do registro](/consulta/web/img/visualizar.png) ![Acesso ao objeto digital](/consulta/web/img/pdf.png) ![Imprime registro no formato completo](/consulta/web/img/print.png) |
11. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | MATTOS, G. L. M.; OKINO, C. H.; TREVISOL, I. M.; MORES, M. A. Z.; LOPES, L. dos S.; MONTASSIER, H. J. Avaliação da imunidade celular contra isolado de campo de vírus da bronquite infecciosa (VBI) das galinhas. In: ANAIS DA CONFERÊNCIA NACIONAL DE DEFESA AGROPECUÁRIA: Defesa agropecuária a serviço de um estado de excelência, 5, 2014, Florianópolis, SC. Anais... Concórdia: Embrapa Suínos e Aves, 2014. 1 CD-ROM. ISBN 978-85-68630-00-6. P. 353Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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12. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | LOPES, P. D.; OKINO, C. H.; FERNANDO, F. S.; PAVANI, C.; MARIGUELA, V. C.; MONTASSIER, M. DE F. S.; MONTASSIER, H. J. Comparative evaluation of immune responses and protection of chitosan nanoparticles and oil-emulsion adjuvants in avian coronavirus inactivated vaccines in chickens. Vaccines, v.9, n.12, 1457, 2021.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Pecuária Sudeste. |
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13. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OKINO, C. H.; MALAGO JUNIOR, W.; MARCONDES, C. R.; GIGLIOTI, R.; MONTASSIER, H. J.; OLIVEIRA, H. N. DE; OLIVEIRA, M. C. de S. CD4 bovine gene: differential polymorphisms among cattle breeds and a new tool for rapid identification. Veterinary Immunology and Immunopathology, v. 251, sep. 2022, 110462. 18 p.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Pecuária Sudeste. |
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14. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OKINO, C. H.; MORES, M. A. Z.; MONTASSIER, H. J.; MATTOS, G. L. M.; BRENTANO, L.; COLDEBELLA, A.; RITTERBUSCH, G. A.; ESTEVES, P. A.; TREVISOL, I. M. Primary and secondary mucosal immunity after challenge with Brazilian avian infectious bronchitis variant. Journal of the Brazilian Society for Virology, Ribeirão Preto, v. 19, 2014. Suppl. 2. Edição dos anais do 25º. Brazilian Congress of Virology e 9º. Mercosur Meeting of Virology, Ribeirão Preto, set./out, 2014. p. 52Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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15. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | FERNANDO, F. S.; OKINO, C. H.; SILVA, K. R.; FERNANDES, C. C.; GONÇALVES, M. C. M.; MONTASSIER, M. F. S.; VASCONCELOS, R. O.; MONTASSIER, H. J. Increased expression of Interleukin-6 related to nephritis in chickens challenged with an Avian infectious bronchitis virus variant. Pesquisa Veterinária Brasileira, Brasília, DF, v. 35, n. 3, p. 216-222, mar. 2015.Biblioteca(s): Embrapa Unidades Centrais. |
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16. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | LOPES, P. D.; OKINO, C. H.; FERNANDO, F. S.; PAVANI, C.; CASAGRANDE, V. M.; LOPEZ, R. F. V.; MONTASSIER, M. F. de; MONTASSIER, H. J. Inactivated infectious bronchitis virus vaccine encapsulated in chitosan nanoparticles induces mucosal immune responses and effective protection against challenge. Vaccine, v. 36, p. 2630-2636, abr. 2018. 36Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Pecuária Sudeste. |
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17. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OKINO, C. H.; ALESSI, A. C.; MONTASSIER, M. de F. S.; ROSA, A. J. de M.; WANG, X.; MONTASSIER, H. J. Humoral and Cell-Mediated Immune Responses to Different Doses of Attenuated Vaccine Against Avian Infectious Bronchitis Virus. Viral Immunology, Nova York, v. 26, n. 4, p. 1-9, 2013.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
Biblioteca(s): Embrapa Cerrados. |
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18. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BORZI, M. M.; MONTASSIER, M. F. S.; OLIVEIRA, E. S.; SILVA, K. R.; SILVA, F. S.; OKINO, C. H.; MONTASSIER, H. J.; REISCHAK, D.; MENDONÇA, A. de O. Cloned nucleoprotein (NP) gene of avian influenza virus for using as a positive control in syber green I real time RT-PCR (RRT-PCR). In: BRAZILIAN CONGRESS OF VIROLOGY, 23.; MERCOSUR MEETING OF VIROLOGY, 7., 2012, Foz do Iguaçu. Virus and Research? Foz do Iguaçu: SBV, 2012. p. 409. Journal of the Brazilian Society for Virology, v. 17, n. 2, suppl. 1, 2012. Projeto/Plano de Ação: 11.11.11.111.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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19. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | OKINO, C. H.; MORES, M. A. Z.; MATTOS, G. L. M.; ESTEVES, P. A.; BRENTANO, L.; MONTASSIER, H. J.; TREVISOL, I. M. Diferentes respostas imunes locais induzidas após desafio com isolados de campo brasileiros do vírus da bronquite infecciosa das galinhas. In: CONFERÊNCIA FACTA, 2014, Atibaia. [Anais...] Campinas: Fundação APINCO de Ciência e Tecnologia Avícolas, 2014. 1 CD-ROM.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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20. | ![Imagem marcado/desmarcado](/consulta/web/img/desmarcado.png) | BORZI, M. M.; PIZA, V. T.; MONTASSIER, M. F. S.; MORA, A. G.; OKINO, C. H.; REISCHAK, D.; MENDONÇA, A.; MONTASSIER, H. J. Development of a microplate immunocapture (IC) RT-PCR assays for the detection of avian influenza virus (AIV) and infectious bronchitis virus (IBV). In: BRAZILIAN CONGRESS OF VIROLOGY, 23.; MERCOSUR MEETING OF VIROLOGY, 7., 2012, Foz do Iguaçu. Virus and Research? Foz do Iguaçu: SBV, 2012. p.468-469. Journal of the Brazilian Society for Virology, v. 17, n. 2, suppl. 1, 2012. Projeto/Plano de Ação: 11.11.11.111.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Suínos e Aves. |
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Registros recuperados : 25 | |
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