|
|
Registro Completo |
Biblioteca(s): |
Embrapa Amapá. |
Data corrente: |
22/09/2022 |
Data da última atualização: |
14/12/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
MADRID, R. R. M; MATHEWS, P. D.; PATTA, A. C. F.; GONZALES-FLORES, A. P.; RAMIREZ. C. A. B.; RIGONI, V. L. S.; TAVARES-DIAS, M.; MERTINS, O. |
Afiliação: |
RAFAEL R. M. MADRID, UNIVERSIDADE FEDERAL DE SÃO PAULO; PATRICK D. MATHEWS, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANA C. M. F. PATTA, UNIVERSIDADE FEDERAL DE SÃO PAULO; ANAI P. GONZALES-FLORES, INSTITUTE OF RESEARCH OF THE PERUVIAN AMAZON; CARLOS A. B. RAMIREZ, UNIVERSIDADE FEDERAL DE SÃO PAULO; VERA L. S. RIGONI, UNIVERSIDADE FEDERAL DE SÃO PAULO; MARCOS TAVARES DIAS, CPAF-AP; OMAR MERTINS, UNIVERSIDADE FEDERAL DE SÃO PAULO. |
Título: |
Safety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Heliyon, v. 7, n. 1, e05820, Jan. 2021. |
DOI: |
https://doi.org/10.1016/j.heliyon.2020.e05820 |
Idioma: |
Inglês |
Conteúdo: |
The FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anticancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22?170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies. |
Thesagro: |
Peixe. |
Thesaurus Nal: |
Corydoras; Ivermectin. |
Categoria do assunto: |
G Melhoramento Genético |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1146721/1/CPAF-AP-2022-Safety-of-oral-administration-of-high-doses-of-ivermectin.pdf
|
Marc: |
LEADER 01803naa a2200253 a 4500 001 2146721 005 2022-12-14 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.heliyon.2020.e05820$2DOI 100 1 $aMADRID, R. R. M 245 $aSafety of oral administration of high doses of ivermectin by means of biocompatible polyelectrolytes formulation.$h[electronic resource] 260 $c2021 520 $aThe FDA-approved drug ivermectin is applied for treatments of onchocerciasis and lymphatic filariasis. The anticancer and anti-viral activities have been demonstrated stressing possibilities for the drug repurposing and therefore new information on high dosage safety is on demand. We analyzed in vivo tissue responses for high doses of ivermectin using Corydoras fish as animal model. We made intestinal histology and hematologic assays after oral administration of ivermectin transported with polyelectrolytes formulation. Histology showed any apparent damage of intestinal tissues at 0.22?170 mg of ivermectin/kg body weight. Immunofluorescence evidenced delocalization of Myosin-Vb at enterocytes only for the higher dose. Hematology parameters showed random variations after 7 days from administration, but a later apparent recover after 14 and 21 days. The study evaluated the potential of high doses of oral administration of ivermectin formulation, which could be an alternative with benefits in high compliance therapies. 650 $aCorydoras 650 $aIvermectin 650 $aPeixe 700 1 $aMATHEWS, P. D. 700 1 $aPATTA, A. C. F. 700 1 $aGONZALES-FLORES, A. P. 700 1 $aRAMIREZ. C. A. B. 700 1 $aRIGONI, V. L. S. 700 1 $aTAVARES-DIAS, M. 700 1 $aMERTINS, O. 773 $tHeliyon$gv. 7, n. 1, e05820, Jan. 2021.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Amapá (CPAF-AP) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Hortaliças. Para informações adicionais entre em contato com cnph.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Hortaliças. |
Data corrente: |
22/11/2000 |
Data da última atualização: |
22/11/2000 |
Autoria: |
CASTELO BRANCO, M.; FRANCA, F. H.; MEDEIROS, M. A.; LEAL, J. G. T. |
Afiliação: |
EMBRAPA-CNPH, Brasilia, DF. |
Título: |
Use of insecticides for controlling the Brazilian tomato pinworn and the diamonback moth in the Federal District, Brazil: case study. |
Ano de publicação: |
2000 |
Fonte/Imprenta: |
In: INTERNATIONAL CONGRESS OF ENTOMOLOGY, 21.; BRAZILIAN CONGRESS OF ENTOMOLOGY, 18., 2000, Foz do Iguassu, PR. Abstracts... Londrina: SEB / Embrapa Soja, 2000. |
Volume: |
v.2. |
Páginas: |
p.669. |
Série: |
(Embrapa Soja. Documentos, 143). |
Idioma: |
Inglês |
Notas: |
Resumo 2647. |
Palavras-Chave: |
Brasil; Brasilia; Brassicas; Distrito Federal; Pest insects; Resistance. |
Thesagro: |
Cerrado; Controle Químico; Inseticida; Inseto; Lycopersicon Esculentum; Plutella Xylostella; Praga; Resistência; Tomate; Tuta Absoluta. |
Thesaurus NAL: |
Brazil; chemical control; insecticides; tomatoes. |
Categoria do assunto: |
-- |
Marc: |
LEADER 01272naa a2200421 a 4500 001 1768877 005 2000-11-22 008 2000 bl uuuu u00u1 u #d 100 1 $aCASTELO BRANCO, M. 245 $aUse of insecticides for controlling the Brazilian tomato pinworn and the diamonback moth in the Federal District, Brazil$bcase study. 260 $c2000 300 $ap.669. v.2. 490 $a(Embrapa Soja. Documentos, 143).$vv.2. 500 $aResumo 2647. 650 $aBrazil 650 $achemical control 650 $ainsecticides 650 $atomatoes 650 $aCerrado 650 $aControle Químico 650 $aInseticida 650 $aInseto 650 $aLycopersicon Esculentum 650 $aPlutella Xylostella 650 $aPraga 650 $aResistência 650 $aTomate 650 $aTuta Absoluta 653 $aBrasil 653 $aBrasilia 653 $aBrassicas 653 $aDistrito Federal 653 $aPest insects 653 $aResistance 700 1 $aFRANCA, F. H. 700 1 $aMEDEIROS, M. A. 700 1 $aLEAL, J. G. T. 773 $tIn: INTERNATIONAL CONGRESS OF ENTOMOLOGY, 21.; BRAZILIAN CONGRESS OF ENTOMOLOGY, 18., 2000, Foz do Iguassu, PR. Abstracts... Londrina: SEB / Embrapa Soja, 2000.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Hortaliças (CNPH) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Expressão de busca inválida. Verifique!!! |
|
|