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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
02/02/2018 |
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Data da última atualização: |
09/03/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, S. N.; MELO, I. S. de. |
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Afiliação: |
SUIKINAI NOBRE SANTOS, FAPESP; ITAMAR SOARES DE MELO, CNPMA. |
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Título: |
A rapid primary screening method for antitumor using the oomycete Pythium aphanidermatum. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Natural Products Chemistry & Research, v. 4, n. 6, 2016. |
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DOI: |
10.4172/2329-6836.1000241 |
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Idioma: |
Inglês |
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Conteúdo: |
Investigating bioactive components from microbial metabolites can provide potential source for drug discovery. There are a number of traditional antitumor compounds screening assays already described. In this study, we have developed an efficient method to search for antitumor compounds using the Oomycete Pythium aphanidermatum as model on agar plates for high throughtput screening. Antioomycete compounds showed cytotoxic effects in human cancer cells lines due to the possible similarity between the lipid cell membrane of the Pythium species and cancerous cells, suggesting the compounds act through similar mechanisms of inhibition. In this assay, i t is possible to evaluate hundreds of samples, with results in few hours. The Pythium assay was shown to be sensitive for several chemical substances and allowed the detection and isolation of antitumor compounds from microorganisms. This bioassay was shown to be sensitive, rapid, simple and reliable for antitumor activity. It takes just few hours to evaluate the properties of the extracts. |
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Palavras-Chave: |
Antifungal assay; Antitumoral screening. |
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Thesagro: |
Pythium Aphanidermatum. |
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Thesaurus Nal: |
Antineoplastic agents; Screening; secondary metabolites. |
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Categoria do assunto: |
S Ciências Biológicas |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/172110/1/2017AP61.pdf
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Marc: |
LEADER 01732naa a2200217 a 4500
001 2087004
005 2018-03-09
008 2016 bl uuuu u00u1 u #d
024 7 $a10.4172/2329-6836.1000241$2DOI
100 1 $aSANTOS, S. N.
245 $aA rapid primary screening method for antitumor using the oomycete Pythium aphanidermatum.$h[electronic resource]
260 $c2016
520 $aInvestigating bioactive components from microbial metabolites can provide potential source for drug discovery. There are a number of traditional antitumor compounds screening assays already described. In this study, we have developed an efficient method to search for antitumor compounds using the Oomycete Pythium aphanidermatum as model on agar plates for high throughtput screening. Antioomycete compounds showed cytotoxic effects in human cancer cells lines due to the possible similarity between the lipid cell membrane of the Pythium species and cancerous cells, suggesting the compounds act through similar mechanisms of inhibition. In this assay, i t is possible to evaluate hundreds of samples, with results in few hours. The Pythium assay was shown to be sensitive for several chemical substances and allowed the detection and isolation of antitumor compounds from microorganisms. This bioassay was shown to be sensitive, rapid, simple and reliable for antitumor activity. It takes just few hours to evaluate the properties of the extracts.
650 $aAntineoplastic agents
650 $aScreening
650 $asecondary metabolites
650 $aPythium Aphanidermatum
653 $aAntifungal assay
653 $aAntitumoral screening
700 1 $aMELO, I. S. de
773 $tNatural Products Chemistry & Research$gv. 4, n. 6, 2016.
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Registro original: |
Embrapa Meio Ambiente (CNPMA) |
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Registro |
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Registro Completo
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
15/12/2010 |
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Data da última atualização: |
12/07/2019 |
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Tipo da produção científica: |
Folder/Folheto/Cartilha |
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Autoria: |
MATTOS, M. L. T.; MADAIL, J. C. M. |
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Afiliação: |
MARIA LAURA TURINO MATTOS, CPACT; JOAO CARLOS MEDEIROS MADAIL, CPACT. |
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Título: |
Educação ambiental em propriedade familiar. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
Pelotas: Embrapa Clima Temperado, 2010. |
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Páginas: |
2 p. |
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Descrição Física: |
1 folder. |
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Idioma: |
Português |
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Palavras-Chave: |
Boas práticas. |
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Thesagro: |
Agricultura familiar; Educação; Educação ambiental; Qualidade da água. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/37324/1/Educacao.ambiental.pdf
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Marc: |
LEADER 00527nam a2200181 a 4500
001 1870064
005 2019-07-12
008 2010 bl uuuu u0uu1 u #d
100 1 $aMATTOS, M. L. T.
245 $aEducação ambiental em propriedade familiar.$h[electronic resource]
260 $aPelotas: Embrapa Clima Temperado$c2010
300 $a2 p.$c1 folder.
650 $aAgricultura familiar
650 $aEducação
650 $aEducação ambiental
650 $aQualidade da água
653 $aBoas práticas
700 1 $aMADAIL, J. C. M.
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Registro original: |
Embrapa Clima Temperado (CPACT) |
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