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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
02/02/2018 |
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Data da última atualização: |
09/03/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
SANTOS, S. N.; MELO, I. S. de. |
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Afiliação: |
SUIKINAI NOBRE SANTOS, FAPESP; ITAMAR SOARES DE MELO, CNPMA. |
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Título: |
A rapid primary screening method for antitumor using the oomycete Pythium aphanidermatum. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Natural Products Chemistry & Research, v. 4, n. 6, 2016. |
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DOI: |
10.4172/2329-6836.1000241 |
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Idioma: |
Inglês |
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Conteúdo: |
Investigating bioactive components from microbial metabolites can provide potential source for drug discovery. There are a number of traditional antitumor compounds screening assays already described. In this study, we have developed an efficient method to search for antitumor compounds using the Oomycete Pythium aphanidermatum as model on agar plates for high throughtput screening. Antioomycete compounds showed cytotoxic effects in human cancer cells lines due to the possible similarity between the lipid cell membrane of the Pythium species and cancerous cells, suggesting the compounds act through similar mechanisms of inhibition. In this assay, i t is possible to evaluate hundreds of samples, with results in few hours. The Pythium assay was shown to be sensitive for several chemical substances and allowed the detection and isolation of antitumor compounds from microorganisms. This bioassay was shown to be sensitive, rapid, simple and reliable for antitumor activity. It takes just few hours to evaluate the properties of the extracts. |
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Palavras-Chave: |
Antifungal assay; Antitumoral screening. |
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Thesagro: |
Pythium Aphanidermatum. |
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Thesaurus Nal: |
Antineoplastic agents; Screening; secondary metabolites. |
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Categoria do assunto: |
S Ciências Biológicas |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/172110/1/2017AP61.pdf
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Marc: |
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001 2087004
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008 2016 bl uuuu u00u1 u #d
024 7 $a10.4172/2329-6836.1000241$2DOI
100 1 $aSANTOS, S. N.
245 $aA rapid primary screening method for antitumor using the oomycete Pythium aphanidermatum.$h[electronic resource]
260 $c2016
520 $aInvestigating bioactive components from microbial metabolites can provide potential source for drug discovery. There are a number of traditional antitumor compounds screening assays already described. In this study, we have developed an efficient method to search for antitumor compounds using the Oomycete Pythium aphanidermatum as model on agar plates for high throughtput screening. Antioomycete compounds showed cytotoxic effects in human cancer cells lines due to the possible similarity between the lipid cell membrane of the Pythium species and cancerous cells, suggesting the compounds act through similar mechanisms of inhibition. In this assay, i t is possible to evaluate hundreds of samples, with results in few hours. The Pythium assay was shown to be sensitive for several chemical substances and allowed the detection and isolation of antitumor compounds from microorganisms. This bioassay was shown to be sensitive, rapid, simple and reliable for antitumor activity. It takes just few hours to evaluate the properties of the extracts.
650 $aAntineoplastic agents
650 $aScreening
650 $asecondary metabolites
650 $aPythium Aphanidermatum
653 $aAntifungal assay
653 $aAntitumoral screening
700 1 $aMELO, I. S. de
773 $tNatural Products Chemistry & Research$gv. 4, n. 6, 2016.
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Registro original: |
Embrapa Meio Ambiente (CNPMA) |
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| Registros recuperados : 4 | |
| 1. |  | SOUSA, K. A. O. de; LOPES, P. R. C.; CUNHA, J. G. da; SILVA, L. dos S.; CARREIRO, D. de A. Paclobutrazol na redução de vigor de pereira 'santa maria' no Submédio Vale do São Francisco. In: CONGRESSO BRASILEIRO DE FRUTICULTURA, 26., 2019, Juazeiro, BA/Petrolina, PE. Fruticultura de precisão: desafios e oportunidades - anais. Petrolina: Embrapa Semiárido: UNIVASF: SBF, 2019. p. 1559-1562.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido. |
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| 2. | | SOARES FILHO, A. de A.; LINO, J. de O. S.; CUNHA, J. G. da; SANTANA, E. A.; OLIVEIRA, V. R. de; FREITAS, S. T. de. Uso de hexanal para aumentar a vida pós-colheita do umbu. In: CONGRESSO BRASILEIRO DE FRUTICULTURA, 26., 2019, Juazeiro, BA/Petrolina, PE. Fruticultura de precisão: desafios e oportunidades - anais. Petrolina: Embrapa Semiárido: UNIVASF: SBF, 2019. p. 2777-2780.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido. |
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| 3. | | ANDRADE, M. J. K. L.; OLIVEIRA, A. S. DE; SANTOS, W. F. DOS; SILVA, L. DOS S.; CUNHA, J. G. DA; SOUTO, A. G. DE L.; CAVALCANTE, I. H. L. Development of Israeli mango cultivars in the Brazilian semiarid region. Pesquisa Agropecuária Brasileira, v. 58, e03173, 2023. Título em português: Desenvolvimento de cultivares de mangueiras israelenses no semiárido brasileiro.| Biblioteca(s): Embrapa Unidades Centrais. |
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| 4. | | CAVALCANTE, I. H. L.; SILVA, G. J. N. e; CAVACINI, J. A.; AMARIZ, R. A. e; FREITAS, S. T. de; SOUSA, K, A. O. de; SILVA, M. A. da; CUNHA, J. G. da. Metconazole on inhibition of gibberellin biosynthesis and flowering management in mango. Erwerbs-Obstbau, v. 62, n. 1, p. 89-95, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Semiárido. |
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| Registros recuperados : 4 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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