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Registro Completo |
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Biblioteca(s): |
Embrapa Clima Temperado. |
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Data corrente: |
27/12/2023 |
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Data da última atualização: |
27/12/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MELLO, J. E. DE; LUDUVICO, K. P.; SANTOS, A. DOS; TEIXEIRA, F. C.; CARDOSO, J. DE S.; AGUIAR, M. S. S. DE; CUNICO, W.; VIZZOTTO, M.; STEFANELLO, F.; SPANEVELLO, R. |
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Afiliação: |
JULIA EISENHARDT DE MELLO, UNIVERSIDADE FEDERAL DE PELOTAS; KARINA PEREIRA LUDUVICO, UNIVERSIDADE FEDERAL DE PELOTAS; ALESSANDRA DOS SANTOS, UNIVERSIDADE FEDERAL DE PELOTAS; FERNANDA CARDOSO TEIXEIRA, UNIVERSIDADE FEDERAL DE PELOTAS; JULIANE DE SOUZA CARDOSO, UNIVERSIDADE FEDERAL DE PELOTAS; MAYARA SANDRIELLY SOARES DE AGUIAR, UNIVERSIDADE FEDERAL DE PELOTAS; WILSON CUNICO, UNIVERSIDADE FEDERAL DE PELOTAS; MARCIA VIZZOTTO FOSTER, CPACT; FRANCIELI STEFANELLO, UNIVERSIDADE FEDERAL DE PELOTAS; ROSELIA SPANEVELLO, UNIVERSIDADE FEDERAL DE PELOTAS. |
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Título: |
Therapeutic potential of blackberry extract in the preventing memory defcits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Metabolic Brain Disease, v. 38, p. 1261–1272, 2023. |
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DOI: |
https://doi.org/10.1007/s11011-023-01175-w |
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Idioma: |
Inglês |
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Conteúdo: |
The blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholinesterase activities of Rubus sp. are associated with memory improvement; hence, it can potentially be used for the treatment of neurodegenerative diseases. MenosThe blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholi... Mostrar Tudo |
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Thesagro: |
Amora; Amora Preta; Extrato; Extrato de Fruta. |
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Thesaurus Nal: |
Rubus. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02619naa a2200301 a 4500
001 2160274
005 2023-12-27
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s11011-023-01175-w$2DOI
100 1 $aMELLO, J. E. DE
245 $aTherapeutic potential of blackberry extract in the preventing memory defcits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia.$h[electronic resource]
260 $c2023
520 $aThe blackberry (Rubus sp.) is a popular fruit that has a high concentration of phenolic compounds. Pharmacological investigations have demonstrated the important biological activities of the blackberry extract, such as neuroprotective actions. This study aimed to evaluate the efects of blackberry extract on memory and neurochemical parameters in rats subjected to scopolamine (SCO)-induced amnesia. Male rats were divided into fve groups: I, control (saline); II, SCO; III, SCO +Rubus sp. (100 mg/kg); IV, SCO+Rubus sp. (200 mg/kg); and V, SCO+donepezil (5 mg/kg). Blackberry extract and donepezil were orally administered for 10 days. On day 11, group I received saline, and groups II, III, IV, and V received SCO (1 mg/kg) intraperitoneally after object recognition behavioral training. Twenty-four hours after the training session, animals were subjected to an object recognition test. Finally, the animals were euthanized, and the cerebral cortex, hippocampus, and cerebellum were collected to evaluate the oxidative stress and acetylcholinesterase (AChE) activity. Rubus sp. extract prevented memory impairment induced by SCO in a manner similar to that of donepezil. Additionally, Rubus sp. extract and donepezil prevented the increase in AChE activity induced by SCO in all the evaluated brain structures. SCO induced oxidative damage in the cerebral cortex, hippocampus, and cerebellum, which was prevented by Rubus sp. and donepezil. Our results suggest that the antioxidant and anticholinesterase activities of Rubus sp. are associated with memory improvement; hence, it can potentially be used for the treatment of neurodegenerative diseases.
650 $aRubus
650 $aAmora
650 $aAmora Preta
650 $aExtrato
650 $aExtrato de Fruta
700 1 $aLUDUVICO, K. P.
700 1 $aSANTOS, A. DOS
700 1 $aTEIXEIRA, F. C.
700 1 $aCARDOSO, J. DE S.
700 1 $aAGUIAR, M. S. S. DE
700 1 $aCUNICO, W.
700 1 $aVIZZOTTO, M.
700 1 $aSTEFANELLO, F.
700 1 $aSPANEVELLO, R.
773 $tMetabolic Brain Disease$gv. 38, p. 1261–1272, 2023.
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| 11. |  | SILVA, D. S.; MELLO, J. S. R.; CASTRO, I. M. Rapida determinacao de teobromina, teofilina e cafeina por HPLC em bebida de guarana e achocolatados. In: CONGRESSO BRASILEIRO DE CIENCIA E TECNOLOGIA DE ALIMENTOS, 17., 2000, Fortaleza, CE. Livro de resumos... Fortaleza: SBCTA, 2000. v.4 , p. 2.43, 2000.| Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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