|
Registro Completo |
|
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
|
Data corrente: |
22/11/2002 |
|
Data da última atualização: |
22/11/2002 |
|
Autoria: |
ROY, F.; COMBES, B.; VAIMAN, D.; CRIBIU, E. P.; POBEL, T.; DELÉTANG, F.; COMBARNOUS, Y.; GUILLOU, F.; MAUREL, M. C. |
|
Título: |
Humoral immune response to equine chorionic gonadotropin in ewes: association with major histocompatibility complex and interference with subsequent fertility. |
|
Ano de publicação: |
1999 |
|
Fonte/Imprenta: |
Biology of Reproduction and Fertility, v. 61, n. 1, p. 209-218, 1999. |
|
Idioma: |
Inglês |
|
Conteúdo: |
In dairy ewes, lhe use of eCG as a convenient hormone for the induction of ovulation is necessary for out-of-season breeding and artificial insemination (AI). In this report we show lhe presence of anti-eCG antibodies in plasma of treated ewes. The major histocompatibility complex (MHC) was involved in the I individual variability of the humoral immune responses to eCG. We found significant associations between the anti-eCG response phenotype and some MHC class II alleles. The low immune response phenotype was associated with one MHC class II allele only in Lacaune ewes, and the high immune response phenotype was associated with one MHC class II allele both in Manech and in Lacaune ewes. In herds, the impact of residual anti-eCG antibodies on subsequent fertility after AI seems minimal because of an indirect elimination of high-responder ewes I from AI breeding. Therefore, the true magnitude of the association between residual anti-eCG antibody concentration and fertility has been underestimated. An additional experiment I without any high-responder female elimination showed a significant correlation between high residual antibody concentrations and lower lambing rate after AI at a fixed time, possibly because of a delayed preovulatory LH surge. The results suggest that anti-eCC antibody concentration is one risk factor for infertility after AI. |
|
Palavras-Chave: |
eCG; Gonadotropina carionica equina. |
|
Thesagro: |
Imunologia; Ovino; Reprodução Animal. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02196naa a2200277 a 4500
001 1528881
005 2002-11-22
008 1999 bl uuuu u00u1 u #d
100 1 $aROY, F.
245 $aHumoral immune response to equine chorionic gonadotropin in ewes$bassociation with major histocompatibility complex and interference with subsequent fertility.
260 $c1999
520 $aIn dairy ewes, lhe use of eCG as a convenient hormone for the induction of ovulation is necessary for out-of-season breeding and artificial insemination (AI). In this report we show lhe presence of anti-eCG antibodies in plasma of treated ewes. The major histocompatibility complex (MHC) was involved in the I individual variability of the humoral immune responses to eCG. We found significant associations between the anti-eCG response phenotype and some MHC class II alleles. The low immune response phenotype was associated with one MHC class II allele only in Lacaune ewes, and the high immune response phenotype was associated with one MHC class II allele both in Manech and in Lacaune ewes. In herds, the impact of residual anti-eCG antibodies on subsequent fertility after AI seems minimal because of an indirect elimination of high-responder ewes I from AI breeding. Therefore, the true magnitude of the association between residual anti-eCG antibody concentration and fertility has been underestimated. An additional experiment I without any high-responder female elimination showed a significant correlation between high residual antibody concentrations and lower lambing rate after AI at a fixed time, possibly because of a delayed preovulatory LH surge. The results suggest that anti-eCC antibody concentration is one risk factor for infertility after AI.
650 $aImunologia
650 $aOvino
650 $aReprodução Animal
653 $aeCG
653 $aGonadotropina carionica equina
700 1 $aCOMBES, B.
700 1 $aVAIMAN, D.
700 1 $aCRIBIU, E. P.
700 1 $aPOBEL, T.
700 1 $aDELÉTANG, F.
700 1 $aCOMBARNOUS, Y.
700 1 $aGUILLOU, F.
700 1 $aMAUREL, M. C.
773 $tBiology of Reproduction and Fertility$gv. 61, n. 1, p. 209-218, 1999.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
|
