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 | Acesso ao texto completo restrito à biblioteca da Embrapa Pecuária Sudeste. Para informações adicionais entre em contato com cppse.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Pecuária Sudeste. |
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Data corrente: |
20/10/2016 |
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Data da última atualização: |
07/11/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PEREIRA, G. L.; MATTEIS, R. de; MEIRA, C. T.; REGITANO, L. C. de A.; SILVA, J. A. II V.; CHARDULO, L. A. L.; CURI, R. A. |
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Afiliação: |
GUILHERME L. PEREIRA, UNESP; RAFAEL DE MATTEIS, UNESP; CAMILA TANGARI MEIRA, UNESP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; JOSINEUDSON AUGUSTO II V. SILVA, UNESP; LUIS ARTHUR L. CHARDULO, UNESP; ROGÉRIO A. CURI, UNESP. |
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Título: |
Comparison of sequence variants in the PDK4 and COX4I2 genes between racing and cutting lines of quarter horses and associations with the speed index. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Journal of Equine Veterinary Science, v.39, p.1-6, 2016. |
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Volume: |
39 |
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Páginas: |
1-6 |
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DOI: |
http://dx.doi.org/10.1016/j.jevs.2015.07.001 |
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Idioma: |
Inglês |
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Conteúdo: |
Different selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A singlenucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX4I2 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX4I2 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX4I2 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic. MenosDifferent selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A singlenucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX4I2 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX4I2 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX4I2 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic... Mostrar Tudo |
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Palavras-Chave: |
Gene candidato; QTL. |
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Thesagro: |
Eqüino; Polimorfismo. |
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Thesaurus Nal: |
Horses. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02509naa a2200289 a 4500
001 2055100
005 2018-11-07
008 2016 bl uuuu u00u1 u #d
024 7 $ahttp://dx.doi.org/10.1016/j.jevs.2015.07.001$2DOI
100 1 $aPEREIRA, G. L.
245 $aComparison of sequence variants in the PDK4 and COX4I2 genes between racing and cutting lines of quarter horses and associations with the speed index.$h[electronic resource]
260 $c2016
300 $a1-6 39
490 $v39
520 $aDifferent selection objectives within the Quarter Horse breed led to the formation of groups with distinct skills, including the racing and cutting lines. With a smaller population size in Brazil, but of great economic representativeness, the racing line is characterized by animals that can reach high speeds over short distances and within a short period of time. The cutting line is destined for functional tests, exploring skills such as agility and obedience. Although the athletic performance of horses is likely to be influenced by a large number of genes, few genetic variants have so far been related to this trait and this was done exclusively in Thoroughbreds, including the g.38973231G>A singlenucleotide polymorphism in the PDK4 gene and the g.22684390C>T single-nucleotide polymorphism in the COX4I2 gene. The results of the present study demonstrate the presence of polymorphic PDK4 and COX4I2 genes in Quarter Horses. The analysis of 296 racing animals and 68 cutting animals revealed significant differences in allele and genotype frequencies between the two lines. The same was not observed when these frequencies were compared between extreme racing performance phenotypes. There were also no significant associations between alleles of the two polymorphisms and the speed index. These results suggest that the alleles of the PDK4 and COX4I2 genes, which are related to better racecourse performance in Thoroughbreds, are probably associated with beneficial adaptations in aerobic metabolism and therefore play secondary roles in sprint racing performance in Quarter Horses, which is mainly anaerobic.
650 $aHorses
650 $aEqüino
650 $aPolimorfismo
653 $aGene candidato
653 $aQTL
700 1 $aMATTEIS, R. de
700 1 $aMEIRA, C. T.
700 1 $aREGITANO, L. C. de A.
700 1 $aSILVA, J. A. II V.
700 1 $aCHARDULO, L. A. L.
700 1 $aCURI, R. A.
773 $tJournal of Equine Veterinary Science$gv.39, p.1-6, 2016.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
20/06/2022 |
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Data da última atualização: |
20/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
BORGES, F. A.; DRAGO, B. C.; BAGGIO, L. O.; BARROS, N. R. de; BRASIL, G. S. P.; SCONTRI, M.; MUSSAGY, C. U.; RIBEIRO, M. C. S.; MILORI, D. M. B. P.; MORAIS, C. P. de; MARANGONI, B. S.; NICOLODELLI, G.; MECWAN, M.; MANDAL, K.; GUERRA, N. B.; MENEGATTI, C. R.; HERCULANO, R. D. |
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Afiliação: |
DEBORA MARCONDES BASTOS PEREIRA, CNPDIA. |
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Título: |
Metronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
International Journal of Biological Macromolecules, v. 211, 2022. |
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Páginas: |
568?579 |
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ISSN: |
0141-8130 |
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DOI: |
https://doi.org/10.1016/j.ijbiomac.2022.05.025 |
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Idioma: |
Inglês |
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Conteúdo: |
Gold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV?Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 ± 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications |
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Palavras-Chave: |
Gold nanoparticles; LIBS; Sustained release. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02515naa a2200385 a 4500
001 2144181
005 2022-06-20
008 2022 bl uuuu u00u1 u #d
022 $a0141-8130
024 7 $ahttps://doi.org/10.1016/j.ijbiomac.2022.05.025$2DOI
100 1 $aBORGES, F. A.
245 $aMetronidazole-loaded gold nanoparticles in natural rubber latex as a potential wound dressing.$h[electronic resource]
260 $c2022
300 $a568?579
520 $aGold nanoparticles (AuNPs) have shown interesting properties and specific biofunctions, providing benefits and new opportunities for controlled release systems. In this research, we demonstrated the use of natural rubber latex (NRL) from Hevea brasiliensis as a carrier of AuNPs and the antibiotic metronidazole (MET). We prepared AuNP-MET-NRL and characterized by physicochemical, biological and in vitro release assays. The effect of AuNPs on MET release was evaluated using UV?Vis and Laser-Induced Breakdown Spectroscopy (LIBS) techniques. AuNPs synthesized by Turkevich and Frens method resulted in a spherical shape with diameters of 34.8 ± 5.5 nm. We verified that there was no emergence or disappearance of new vibrational bands. Qualitatively and quantitatively, we showed that the MET crystals dispersed throughout the NRL. The Young's modulus and elongation values at dressing rupture were in the range appropriate for human skin application. 64.70% of the AuNP-MET complex was released within 100 h, exhibiting a second-order exponential release profile. The LIBS technique allowed monitoring of the AuNP release, indicating the Au emission peak reduction at 267.57 nm over time. Moreover, the dressing displayed an excellent hemocompatibility and fibroblast cell viability. These results demonstrated that the AuNP-MET-NRL wound dressing is a promising approach for dermal applications
653 $aGold nanoparticles
653 $aLIBS
653 $aSustained release
700 1 $aDRAGO, B. C.
700 1 $aBAGGIO, L. O.
700 1 $aBARROS, N. R. de
700 1 $aBRASIL, G. S. P.
700 1 $aSCONTRI, M.
700 1 $aMUSSAGY, C. U.
700 1 $aRIBEIRO, M. C. S.
700 1 $aMILORI, D. M. B. P.
700 1 $aMORAIS, C. P. de
700 1 $aMARANGONI, B. S.
700 1 $aNICOLODELLI, G.
700 1 $aMECWAN, M.
700 1 $aMANDAL, K.
700 1 $aGUERRA, N. B.
700 1 $aMENEGATTI, C. R.
700 1 $aHERCULANO, R. D.
773 $tInternational Journal of Biological Macromolecules$gv. 211, 2022.
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Embrapa Instrumentação (CNPDIA) |
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