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Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
23/09/2002 |
Data da última atualização: |
23/09/2002 |
Autoria: |
TOKUDA, T.; MATSUI, T.; ITO, J.; TORII, S.; YANO, H. |
Título: |
The changes in body weight and plasma metabolite levels during leptin injection are caused by the reduction of food intake in sheep. |
Ano de publicação: |
2000 |
Fonte/Imprenta: |
Animal Science, v.70, n.2, p.343-348, 2000. |
Idioma: |
Inglês |
Conteúdo: |
Leptin is thought to act on the central nervous system as an important regulator of food intake and body weight in mire. To examine the actions of leptin in sheep, we injected recombinant mouse leptin into the lateral cerebral ventricle of ewes. Six ewes were intracerebroventricularly cannulated and given free access to forage and water. The ewes were injected with phosphate-buffered saline (PBS) as a vehicle for 5 days through the cannula and then with PBS + leptin for 7 days consecutively. Although food intake and body weight did not change during PBS injection, lhe administration of leptin decreased food intake and body weight. Plasma glucose levels decreased and plasma non-esterified fatty acid levels increased on the last few days of leptin administration. Approximately 2 weeks after normal food intake was recovered, the amount of diet was individually reduced in accordance with the recorded food intake during the leptin administration in each sheep. During food restriction, body weight and plasma metabolite concentrations were similarly changed as during the leptin-administration period. These results indicate that leptin decreases food intake in sheep. Moreover, it is likely that the changes in body weight and plasma metabolites were mainly induced by the suppression of food intake during leptin injection. |
Palavras-Chave: |
Ácidos graxos; Consumo voluntário; Peso corporal. |
Thesagro: |
Glicose; Nutrição Animal; Ovino. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02009naa a2200241 a 4500 001 1528621 005 2002-09-23 008 2000 bl uuuu u00u1 u #d 100 1 $aTOKUDA, T. 245 $aThe changes in body weight and plasma metabolite levels during leptin injection are caused by the reduction of food intake in sheep. 260 $c2000 520 $aLeptin is thought to act on the central nervous system as an important regulator of food intake and body weight in mire. To examine the actions of leptin in sheep, we injected recombinant mouse leptin into the lateral cerebral ventricle of ewes. Six ewes were intracerebroventricularly cannulated and given free access to forage and water. The ewes were injected with phosphate-buffered saline (PBS) as a vehicle for 5 days through the cannula and then with PBS + leptin for 7 days consecutively. Although food intake and body weight did not change during PBS injection, lhe administration of leptin decreased food intake and body weight. Plasma glucose levels decreased and plasma non-esterified fatty acid levels increased on the last few days of leptin administration. Approximately 2 weeks after normal food intake was recovered, the amount of diet was individually reduced in accordance with the recorded food intake during the leptin administration in each sheep. During food restriction, body weight and plasma metabolite concentrations were similarly changed as during the leptin-administration period. These results indicate that leptin decreases food intake in sheep. Moreover, it is likely that the changes in body weight and plasma metabolites were mainly induced by the suppression of food intake during leptin injection. 650 $aGlicose 650 $aNutrição Animal 650 $aOvino 653 $aÁcidos graxos 653 $aConsumo voluntário 653 $aPeso corporal 700 1 $aMATSUI, T. 700 1 $aITO, J. 700 1 $aTORII, S. 700 1 $aYANO, H. 773 $tAnimal Science$gv.70, n.2, p.343-348, 2000.
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Embrapa Caprinos e Ovinos (CNPC) |
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