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Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
Data corrente: |
02/12/2016 |
Data da última atualização: |
25/09/2017 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
TONUCCI, L. B.; SANTOS, K. M. O. dos; OLIVEIRA, L. L. de; RIBEIRO, S. M. R.; MARTINO, H. S. D. |
Afiliação: |
Livia Bordalo Tonucci, INTA; KARINA MARIA OLBRICH DOS SANTOS, CTAA; Leandro Licursi de Oliveira, UFV; Sonia Machado Rocha Ribeiro, UFV; Hercia Stampini Duarte Martino, UFV. |
Título: |
Clinical application of probiotics in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Clinical Nutrition, v. 36, n. 1, p. 85-92, 2017. |
DOI: |
10.1016/j.clnu.2015.11.011. |
Idioma: |
Inglês |
Conteúdo: |
Background & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of HbA1c (þ0.31 for control group vs 0.65 for probiotic group; p ¼ 0.02), total cholesterol (þ0.55 for control group vs 0.15 for probiotic group; p ¼ 0.04) and LDL-cholesterol (þ0.36 for control group vs 0.20 for probiotic group p ¼ 0.03). Conclusions: Probiotic consumption improved the glycemic control in T2D subjects, however, the intake of fermented milk seems to be involved with others metabolic changes, such as decrease in inflammatory cytokines (TNF-a and resistin) and increase in the acetic acid. MenosBackground & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of Hb... Mostrar Tudo |
Palavras-Chave: |
Gut microbiota; Oxidative; Type 2 diabetes. |
Thesagro: |
Stress. |
Thesaurus Nal: |
inflammation; probiotics. |
Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 02784naa a2200253 a 4500 001 2057801 005 2017-09-25 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1016/j.clnu.2015.11.011.$2DOI 100 1 $aTONUCCI, L. B. 245 $aClinical application of probiotics in type 2 diabetes mellitus$ba randomized, double-blind, placebo-controlled study.$h[electronic resource] 260 $c2017 520 $aBackground & aims: Type 2 diabetes has been associated with dysbiosis and one of the possible routes to restore a healthy gut microbiota is by the regular ingestion of probiotics. We aimed to investigate the effects of probiotics on glycemic control, lipid profile, inflammation, oxidative stress and short chain fatty acids in T2D. Methods: In a double-blind, randomized, placebo-controlled trial, 50 volunteers consumed daily 120 g/d of fermented milk for 6 wk. Participants were assigned into two groups: probiotic group, consuming fermented milk containing Lactobacillus acidophilus La-5 and Bifidobacterium animalis subsp lactis BB-12 (109 colony-forming units/d, each) and control group, consuming conventional fermented milk. Anthropometric measurements, body composition, fasting blood and faecal samples were taken at baseline and after 6 wk. Results: 45 subjects out of 50 (90%) completed follow-up. After 6 wk, there was a significant decrease in fructosamine levels (9.91 mmol/L; p ¼ 0.04) and hemoglobin A1c tended to be lower (0.67%; p ¼ 0.06) in probiotic group. TNF-a and resistin were significantly reduced in probiotic and control groups (1.5 and 1.3 pg/mL, .1 and 2.8 ng/mL, respectively), while IL-10 was significantly reduced ( 0.65 pg/mL; p < 0.001) only in the control group. Fecal acetic acid was increased in both groups (0.58 and 0.59% in probiotic and control groups, respectively; p < 0.01). There was a significant difference between groups concerning mean changes of HbA1c (þ0.31 for control group vs 0.65 for probiotic group; p ¼ 0.02), total cholesterol (þ0.55 for control group vs 0.15 for probiotic group; p ¼ 0.04) and LDL-cholesterol (þ0.36 for control group vs 0.20 for probiotic group p ¼ 0.03). Conclusions: Probiotic consumption improved the glycemic control in T2D subjects, however, the intake of fermented milk seems to be involved with others metabolic changes, such as decrease in inflammatory cytokines (TNF-a and resistin) and increase in the acetic acid. 650 $ainflammation 650 $aprobiotics 650 $aStress 653 $aGut microbiota 653 $aOxidative 653 $aType 2 diabetes 700 1 $aSANTOS, K. M. O. dos 700 1 $aOLIVEIRA, L. L. de 700 1 $aRIBEIRO, S. M. R. 700 1 $aMARTINO, H. S. D. 773 $tClinical Nutrition$gv. 36, n. 1, p. 85-92, 2017.
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Registro original: |
Embrapa Agroindústria de Alimentos (CTAA) |
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Registros recuperados : 89 | |
7. | | TONUCCI, L. B.; SANTOS, K. M. O. dos; OLIVEIRA, L. L. de; RIBEIRO, S. M. R.; MARTINO, H. S. D. Clinical application of probiotics in type 2 diabetes mellitus: a randomized, double-blind, placebo-controlled study. Clinical Nutrition, v. 36, n. 1, p. 85-92, 2017.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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10. | | TEIXEIRA, O. R.; BATISTA, C. de S.; COLUSSI, R.; MARTINO, H. S. D.; VANIER, N. L.; BASSINELLO, P. Z. Impact of physicochemical properties on the digestibility of Brazilian whole and polished rice genotypes. Cereal Chemistry, v. 98, n. 5, p. 1066-1080, Sept./Oct. 2021.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Arroz e Feijão. |
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11. | | VEREDIANO, T. A.; AGARWAL, N.; MARTINO, H. S. D.; KOLBA, N.; GRANCIERI, M.; PAES, M. C. D.; TAKO, E. Effect of black corn anthocyanin-rich extract (Zea mays L.) on cecal microbial populations in vivo (Gallus gallus). Nutrients, v. 14, n. 21, 4679, 2022.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Milho e Sorgo. |
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12. | | THOMPSON, V. B. de M.; COSTA, N. N. B.; MARTINO, H. S. D.; PAES, M. C. D. The effect of micronized corn fiber on body weight, glycemia, and lipid metabolism in rats fed cafeteria diet. Food Science and Technology, v. 38, n. 3, p. 462-466, July/Sept. 2018.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Milho e Sorgo. |
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13. | | QUEIROZ, V. A. V.; MENEZES, C. B. de; BARROS, F. A. R. de; MARTINO, H. S. D. O sorgo na alimentação humana. In: PEREIRA FILHO, I. A.; RODRIGUES, J. A. S. (Ed.). Sorgo: o produtor pergunta, a Embrapa responde. Brasília, DF: Embrapa, 2015. cap. 15, p. 247-266. (Coleção 500 perguntas, 500 respostas).Tipo: Capítulo em Livro Técnico-Científico |
Biblioteca(s): Embrapa Milho e Sorgo. |
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16. | | QUEIROZ, V. A. V.; MORAES, E. A.; MARTINO, H. S. D.; PAIVA, C. L.; MENEZES, C. B. de. Potencial do sorgo para uso na alimentação humana. Informe Agropecuário, Belo Horizonte, v. 35, n. 278, p. 7-12, jan./fev. 2014.Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
Biblioteca(s): Embrapa Milho e Sorgo. |
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18. | | TEIXEIRA, O. R.; CARVALHO, R. N.; COLUSSI, R.; MARTINO, H. S. D.; VANIER, N. L.; BASSINELLO, P. Z. Textura, amido resistente e digestibilidade In Vitro do amido de arroz de terras altas refrigerado e congelado após a cocção. In: SEMINÁRIO JOVENS TALENTOS, 15., 2021, Santo Antônio de Goiás. Resumos... Brasília, DF: Embrapa; Santo Antônio de Goiás: Embrapa Arroz e Feijão, 2021. p. 45. Evento online.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Arroz e Feijão. |
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19. | | GOMES, M. J. C.; MARTINO, H. S. D.; KOLBA, N.; CHENG, J.; AGARWAL, N.; ROCHA, M. de M.; TAKO, E. Zinc biofortified Cowpea (Vigna unguiculata L. Walp.) soluble extracts modulate assessed cecal bacterial pulations and gut morphology In Vivo (Gallus gallus). Frontiers in Bioscience - Landmark, v. 27, n. 5, 140, 2022.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Meio-Norte. |
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20. | | MARTINO, H. S. D.; DIAS, D. M.; GOMES, M. J. C.; ALVES, N. E. G.; MOREIRA, M. E. de C.; NUTTI, M. R. Alimentos alvo para a biofortificação apresentam elevada qualidade proteica e ação hipoglicemiante em ratos wistar. In: REUNIÃO DE BIOFORTIFICAÇÃO NO BRASIL, 5., 2015, São Paulo. Anais... Brasília, DF: Embrapa, 2015. p. 70-73 T213. Título equivalente: Staple food crops targeted for biofortification have high protein quality and hypoglycemic effect in wistar rats.Tipo: Artigo em Anais de Congresso |
Biblioteca(s): Embrapa Agroindústria de Alimentos. |
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