Data/hora: 20/06/2024 03:10:58

Biblioteca(s): 	Embrapa Agricultura Digital.	
Data corrente: 	14/05/2010	
Data da última atualização: 	19/10/2010	
Autoria: 	MARTIN, M.; KETTMANN, R.; DEQUIEDT, F.	
Afiliação: 	MAUD MARTIN, GxABT/ULg; RICHARD KETTMANN, GxABT/ULg; FRANCK DEQUIEDT, GxABT/ULg.	
Título: 	Recent insights into Protein Phosphatase 2A structure and regulation: the reasons why PP2A is no longer considered as a lazy passive housekeeping enzyme.	
Ano de publicação: 	2010	
Fonte/Imprenta: 	Biotechnologie, Agronomie Société et Environnement, Gembloux, v. 14, n. 1, p. 243-252, 2010.	
Idioma: 	Inglês	
Notas: 	The full text of this article is available on - le texte intégral de cet article est disponible sur: http://www.presseagro.be/base/text/v14n1/243.pdf & http://popups.ulg.ac.be/Base.	
Conteúdo: 	Although intracellular signal transduction is often portrayed as a protein kinase "domino effect", the counterbalancing function of phosphatases, and thus the control of phosphatase activity, is equally relevant to proper regulation of cellular function. Protein Phosphatase 2A (PP2A) is a widely expressed family of protein phosphatases made of a core dimer, composed of a catalytic (C) subunit and a structural (A) subunit, in association with a third variable regulatory (B) subunit. Although viewed as a constitutive housekeeping enzyme in the past, PP2A is a highly regulated phosphatase and is emerging as an important regulator of multiple cellular processes involving protein phosphorylation. The regulation of PP2A is mainly accomplished by the identity of the regulatory B-type subunit, which determines substrate specificity, subcellular localization and catalytic activity of the PP2A holoenzyme. In agreement with this, recent findings on the structure and post-translational modifications of PP2A emphasize the importance of PP2A holoenzyme composition in its regulation and pleiotropic activities.	
Palavras-Chave: 	Estrutura da fosfatase 2A; Holoenzyme composition; Phosphatase; PP2A; Regulatory subunits; Subunidade regulatória.	
Thesagro: 	Enzima.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Agricultura Digital (CNPTIA)	
Exemplares: 	CNPTIA - (14854-1) - ADD - AP - PP -  -  -  - DIS