Data/hora: 16/06/2024 00:56:36

Biblioteca(s): 	Embrapa Suínos e Aves.	
Data corrente: 	19/05/2022	
Data da última atualização: 	20/05/2022	
Autoria: 	SANTOS, C. E.; PEIXOTO, J. de O.; FERNANDES, L. T.; MARCELINO, D. E. P.; KAWSKI, V. L.; NEIS, F. T.; LEDUR, M. C.; IBELLI, A. M. G.	
Afiliação: 	CARLOS EDUARDO SANTOS, Unicentro/Guarapuava; JANE DE OLIVEIRA PEIXOTO, CNPSA; LANA TEIXEIRA FERNANDES; DÉBORA ESTER PETRY MARCELINO, FACC; VICKY LILGE KAWSKI, CNPSA; FERNANDA TONELLO NEIS, IFC/Concórdia; MONICA CORREA LEDUR, CNPSA; ADRIANA MERCIA GUARATINI IBELLI, CNPSA.	
Título: 	Upregulated genes in articular cartilage may help to counteract femoral head separation in broilers with 21 days of age.	
Ano de publicação: 	2022	
Fonte/Imprenta: 	Research in Veterinary Science, v. 147, p. 92-95, 2022.	
DOI: 	https://doi.org/10.1016/j.rvsc.2022.04.006	
Idioma: 	Inglês	
Conteúdo: 	Abstract: Femoral head necrosis (FHN) is one of the most common conditions in fast growing broilers, being characterized by separation of articular cartilage from epiphysis and classified as femoral head separation (FHS) or FHS with laceration (FHSL) depending on severity. Although molecular mechanisms involved with this disorder have been observed, its etiology is still unclear. Therefore, the expression of 15 candidate genes, chosen based on previous transcriptomic studies, was evaluated in the articular cartilage (AC) of normal and FHS-affected broilers at 21 days of age. Samples were collected based on the absence or presence of FHS for physical-chemical and qPCR analysis. The AvBD2, RHAG, COL28A1, ADA and ANGPTL7 were upregulated in FHS-affected broilers compared to the healthy group. These genes are involved in immune response, defense against pathogens, inflammation, cellular migration and adhesion, indicating different molecular mechanisms to control FHS progression at early age. Our results can contribute to improve the knowledge on FHN etiology in chickens and other species, such as horse and pigs that are severely affected by bone disorders.	
Palavras-Chave: 	Expressão genética; Femoral head necrosis; Necrose da cabeça femoral; QPCR; Quantitative gene expression.	
Thesagro: 	Ave Domestica; Galinha; Genética Animal; Necrose Animal.	
Thesaurus Nal: 	Chickens; Gene expression.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Suínos e Aves (CNPSA)	
Exemplares: 	CNPSA - (22362-1) - UPC - AP - DD -  -  -  - DIS