Data/hora: 11/06/2024 04:15:45

Biblioteca(s): 	Embrapa Soja.	
Data corrente: 	10/01/2011	
Data da última atualização: 	17/04/2018	
Autoria: 	MARCARINI, J. C.; TSUBOY, M. S. F.; LUIZ, R. C.; RIBEIRO, L. R.; HOFFMANN-CAMPO, C. B.; MANTOVANI, M. S.	
Afiliação: 	JULIANA CRISTINA MARCARINI, UEL; MARCELA STEFANINI FERREIRA TSUBOY, UEL; RODRIGO CABRAL LUIZ, UEL; LUCIA REGINA RIBEIRO, UNESP Rio Claro; CLARA BEATRIZ HOFFMANN CAMPO, CNPSO; MÁRIO SÉRGIO MANTOVANI, UEL.	
Título: 	Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the falvonoid rutin in HTC hepatic cells.	
Ano de publicação: 	2010	
Fonte/Imprenta: 	Experimental and Toxicologic Pathology, Jena, 2010.	
Páginas: 	7 p.	
DOI: 	10.1016/j.etp.2010.03.005	
Idioma: 	Inglês	
Conteúdo: 	Rutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet.	
Thesagro: 	Citogenetica; Flavonoide; Toxidez.	
Thesaurus Nal: 	Cytotoxicity; Flavonoids.	
Categoria do assunto: 	G Melhoramento Genético	
Registro original: 	Embrapa Soja (CNPSO)	
Exemplares: 	CNPSO - (31717-1) - UPC - AP - PP - 11915 -  - 11915 - DIS