Data/hora: 02/06/2024 01:58:15

Biblioteca(s): 	Embrapa Pantanal.	
Data corrente: 	17/07/2014	
Data da última atualização: 	19/05/2017	
Autoria: 	BORSATO, D. M.; PRUDENTE, A. S.; DOLL-BOSCARDIN, P. M.; BORSATO, A. V.; LUZ, C. F. P.; MAIA, B. H. L. N. S.; CABRINI, D. A.; OTUKI, M. F.; MIGUEL, M. D.; FARAGO, P. V.; MIGUEL, O. G.	
Afiliação: 	DÉBORA M. BORSATO, UFPR; ARTHUR S. PRUDENTE, UFPR; PATRÍCIA M. DOLL BOSCARDIN, UEPG; AURELIO VINICIUS BORSATO, CPAP; CYNTHIA F. P. LUZ, INSTITUTO DE BOTÂNICA; BEATRIZ H. L. N. S. MAIA, UFPR; DANIELA A. CABRINI, UFPR; MICHEL F. OTUKI, UEPG; MARILIS D. MIGUEL, UFPR; PAULO V. FARAGO, UEPG; OBDULIO G. MIGUEL, UFPR.	
Título: 	Topical anti-inflammatory activity of a monofloral honey of Mimosa scabrella provided by Melipona marginata during winter in southern Brazil.	
Ano de publicação: 	2014	
Fonte/Imprenta: 	Journal of Medicinal Food, v. 17, n. 7, p. 817-825, 2014.	
ISSN: 	1096-620X	
DOI: 	10.1089/jmf.2013.0024	
Idioma: 	Inglês	
Conteúdo: 	Melipona marginata is an endangered species of stingless bee from Brazil that produces honey with particular physicochemical features and a remarkable exotic flavor. To the best of our knowledge, this is the first report devoted to exploring the medicinal potential of this honey. Thus, the aim of this paper was to investigate the potential anti-inflammatory activity of honey extract from M. marginata on skin inflammation. The honey sample was classified as a monofloral honey of Mimosa scabrella. The presence of 11 phenolic compounds as kaempferol and caffeic acid was detected using the highperformance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-UV-ESI-MS) method. The anti-inflammatory activity was measured using a 12-O-tetradecanoylphorbol-13-acetate-induced ear edema model of inflammation in mice. The topical application of the M. marginata honey extract (1.0 mg/ear) was able to reduce ear edema with an inhibitory effect of 54 ? 5%. This extract decreased the myeloperoxidase activity in 75 ? 3%, which suggests a lower leucocyte infiltration that was confirmed by histological analysis. This extract also provided a reduction of 55 ? 14% in the production of reactive oxygen species. This anti-inflammatory activity could be due to a synergic effect of the phenolic compounds identified in the honey sample. Taken together, these results open up new possibilities for the use of M. marginata honey extract in skin disorders.	
Palavras-Chave: 	Ear edema; HPLC-UV-ESI-MS analysis; Monofloral honey; Pollen analysis; Stingless bee.	
Thesagro: 	Mimosa Scabrella.	
Thesaurus Nal: 	phenolic compounds.	
Categoria do assunto: 	--	
Registro original: 	Embrapa Pantanal (CPAP)	
Exemplares: 	CPAP - (59052-1) - UPC - AP - PP - SP17917 -  - 17917 - DIS