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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
06/08/2012 |
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Data da última atualização: |
06/03/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CASTRO, V. L. S. S. de; MAIA, A. de H. N. |
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Afiliação: |
VERA LUCIA SCHERHOLZ S DE CASTRO, CNPMA; ALINE DE HOLANDA NUNES MAIA, CNPMA. |
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Título: |
Prenatal epoxiconazole exposure effects on rat postnatal development. |
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Ano de publicação: |
2012 |
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Fonte/Imprenta: |
Birth Defects Research. Part B. Developmental and Reproductive Toxicology, v. 95, p. 123-129, 2012. |
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Idioma: |
Inglês |
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Conteúdo: |
Although some studies have pointed out to embryo/fetal toxicity, knowledge about the potential toxicity of the fungicide epoxiconazole is still limited. Once the results of these previous studies have raised some concern, this study studied the effects of epoxiconazole maternal exposure on the physical endpoints in the development of rat pups. To accomplish that, the effects of epoxiconazole (50.0, 100.0, and 150.0 mg/kg) were examined when rats were exposed at two different developmental stages: during the first 6 days of pregnancy or in the organogenesis period (6?15 days). After parturition, pups were tested for growth and maturational milestones. Maternal exposure to the fungicide, independently of phase, resulted in significantly early mean time to vaginal opening and delayed time to testes descent in pups. Weight gain rate in pups and their mothers was not affected for the tested exposure period. The findings of this study emphasize that epoxiconazole maternal exposure may lead to alterations in developmental patterns in nursing pups, consistent with the known influence of epoxiconazole on steroid hormone synthesis. |
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Palavras-Chave: |
Endocrine disruptor; Epoxiconazole prenatal exposure; Rat; Teratogenic effects. |
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Thesagro: |
Fungicida; Rato; Toxidez. |
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Thesaurus Nal: |
Biomarkers; developmental toxicity; Endocrine-disrupting chemicals; Fetal development; Fungicides; Rats; reproduction; Reproductive toxicology; Teratogenicity. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 02103naa a2200325 a 4500
001 1930604
005 2023-03-06
008 2012 bl uuuu u00u1 u #d
100 1 $aCASTRO, V. L. S. S. de
245 $aPrenatal epoxiconazole exposure effects on rat postnatal development.$h[electronic resource]
260 $c2012
520 $aAlthough some studies have pointed out to embryo/fetal toxicity, knowledge about the potential toxicity of the fungicide epoxiconazole is still limited. Once the results of these previous studies have raised some concern, this study studied the effects of epoxiconazole maternal exposure on the physical endpoints in the development of rat pups. To accomplish that, the effects of epoxiconazole (50.0, 100.0, and 150.0 mg/kg) were examined when rats were exposed at two different developmental stages: during the first 6 days of pregnancy or in the organogenesis period (6?15 days). After parturition, pups were tested for growth and maturational milestones. Maternal exposure to the fungicide, independently of phase, resulted in significantly early mean time to vaginal opening and delayed time to testes descent in pups. Weight gain rate in pups and their mothers was not affected for the tested exposure period. The findings of this study emphasize that epoxiconazole maternal exposure may lead to alterations in developmental patterns in nursing pups, consistent with the known influence of epoxiconazole on steroid hormone synthesis.
650 $aBiomarkers
650 $adevelopmental toxicity
650 $aEndocrine-disrupting chemicals
650 $aFetal development
650 $aFungicides
650 $aRats
650 $areproduction
650 $aReproductive toxicology
650 $aTeratogenicity
650 $aFungicida
650 $aRato
650 $aToxidez
653 $aEndocrine disruptor
653 $aEpoxiconazole prenatal exposure
653 $aRat
653 $aTeratogenic effects
700 1 $aMAIA, A. de H. N.
773 $tBirth Defects Research. Part B. Developmental and Reproductive Toxicology$gv. 95, p. 123-129, 2012.
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Registro original: |
Embrapa Meio Ambiente (CNPMA) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
15/10/2001 |
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Data da última atualização: |
16/08/2021 |
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Tipo da produção científica: |
Artigo em Anais de Congresso |
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Autoria: |
BARROS, N. N.; SIMPLICIO, A. A. |
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Afiliação: |
CNPC; CNPC. |
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Título: |
Produção intensiva de ovinos de corte: perspectivas e cruzamentos. |
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Ano de publicação: |
2001 |
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Fonte/Imprenta: |
In: SIMPÓSIO MINEIRO DE OVINOCULTURA, 1., 2001, Lavras, MG. Produção de carne no contexto atual: anais. Lavras, MG: UFLA, 2001. p. 21-48. |
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Idioma: |
Português |
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Conteúdo: |
Potencial produtivo do ovino; Mercado de carne e pele de caprinos e ovinos; Fase de producao. |
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Palavras-Chave: |
Ovino de corte. |
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Thesagro: |
Carne; Cruzamento Animal. |
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Thesaurus NAL: |
Brazil; Crossing; Sheep meat. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 00728nam a2200193 a 4500
001 1515395
005 2021-08-16
008 2001 bl uuuu u01u1 u #d
100 1 $aBARROS, N. N.
245 $aProdução intensiva de ovinos de corte$bperspectivas e cruzamentos.$h[electronic resource]
260 $aIn: SIMPÓSIO MINEIRO DE OVINOCULTURA, 1., 2001, Lavras, MG. Produção de carne no contexto atual: anais. Lavras, MG: UFLA, 2001. p. 21-48.$c2001
520 $aPotencial produtivo do ovino; Mercado de carne e pele de caprinos e ovinos; Fase de producao.
650 $aBrazil
650 $aCrossing
650 $aSheep meat
650 $aCarne
650 $aCruzamento Animal
653 $aOvino de corte
700 1 $aSIMPLICIO, A. A.
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