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Registro Completo |
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Biblioteca(s): |
Embrapa Unidades Centrais. |
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Data corrente: |
01/04/2016 |
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Data da última atualização: |
29/12/2017 |
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Autoria: |
LIMA, L. R. de; MENDES, H. M. F.; SORIANI, F. M.; SOUZA, D. G. de; ALVES, G. E. S.; TEIXEIRA, M. M.; FALEIROS, R. R. |
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Afiliação: |
LEONARDO R. DE LIMA, UFMG; HELOISA M. F. MENDES, UFMG; FREDERICO M. SORIANI, IBC/UFMG; DANIELLE G. DE SOUZA, ICB/UFMG; GERALDO ELENO S. ALVES, UFMG; MAURO M. TEIXEIRA, ICB/UFMG; RAFAEL R. FALEIROS, UFMG. |
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Título: |
Histologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagnist. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Pesquisa Veterinária Brasileira, Rio de Janeiro, v. 36, n. 1, p. 13-18, jan. 2016. |
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Idioma: |
Inglês |
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Conteúdo: |
With the hypothesis that blocking chemokine signaling can ameliorate acute laminitis, the aim was to evaluate the therapeutic effect of intravenous DF1681B, a selective antagonist for CXCR1 and CXCR2 (chemokine receptors), in an oligofructose equine laminitis model. To twelve mixed breed clinically healthy hoses with no previous history of hoof-related lameness was administered oligofructose (10g/kg given by nasogastric tube) and divided into two groups: treated (intravenous DF1681B at 30mg/kg 6, 12, 18, and 24h after oligofructose) and non-treated groups. Laminar biopsies were performed before and 12, 36, and 72h after administering oligofructose. Samples were stained with periodic acid-Schiff (PAS) and scored from 0 to 6 according to epidermal cell and basal membrane changes. The IL-1β, IL-6, and CXCL1 RNA expressions were determined by RT-PCR. Parametric and non-parametric tests were used to compare times within each group (P<0.05). The PAS grades and IL-1β and IL-6 RNA expression increased in the non-treated group, but remained constant in the treated horses. In conclusion, DF1681B therapy reduced laminar inflammation and epidermal deterioration in treated horses. CXCR1/2 blockage should be considered therapeutically for equine acute laminitis. |
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Palavras-Chave: |
CXC receptors; Laminite; Neutrófilo; Quimiocina; Receptores CXC. |
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Thesaurus Nal: |
Chemokines; Horses; Laminitis; Neutrophils. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/141897/1/Histologic-and-inflamatory-lamellar.pdf
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Marc: |
LEADER 02150naa a2200301 a 4500
001 2042319
005 2017-12-29
008 2016 bl uuuu u00u1 u #d
100 1 $aLIMA, L. R. de
245 $aHistologic and inflammatory lamellar changes in horses with oligofructose-induced laminitis treated with a CXCR1/2 antagnist.
260 $c2016
520 $aWith the hypothesis that blocking chemokine signaling can ameliorate acute laminitis, the aim was to evaluate the therapeutic effect of intravenous DF1681B, a selective antagonist for CXCR1 and CXCR2 (chemokine receptors), in an oligofructose equine laminitis model. To twelve mixed breed clinically healthy hoses with no previous history of hoof-related lameness was administered oligofructose (10g/kg given by nasogastric tube) and divided into two groups: treated (intravenous DF1681B at 30mg/kg 6, 12, 18, and 24h after oligofructose) and non-treated groups. Laminar biopsies were performed before and 12, 36, and 72h after administering oligofructose. Samples were stained with periodic acid-Schiff (PAS) and scored from 0 to 6 according to epidermal cell and basal membrane changes. The IL-1β, IL-6, and CXCL1 RNA expressions were determined by RT-PCR. Parametric and non-parametric tests were used to compare times within each group (P<0.05). The PAS grades and IL-1β and IL-6 RNA expression increased in the non-treated group, but remained constant in the treated horses. In conclusion, DF1681B therapy reduced laminar inflammation and epidermal deterioration in treated horses. CXCR1/2 blockage should be considered therapeutically for equine acute laminitis.
650 $aChemokines
650 $aHorses
650 $aLaminitis
650 $aNeutrophils
653 $aCXC receptors
653 $aLaminite
653 $aNeutrófilo
653 $aQuimiocina
653 $aReceptores CXC
700 1 $aMENDES, H. M. F.
700 1 $aSORIANI, F. M.
700 1 $aSOUZA, D. G. de
700 1 $aALVES, G. E. S.
700 1 $aTEIXEIRA, M. M.
700 1 $aFALEIROS, R. R.
773 $tPesquisa Veterinária Brasileira, Rio de Janeiro$gv. 36, n. 1, p. 13-18, jan. 2016.
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Registro original: |
Embrapa Unidades Centrais (AI-SEDE) |
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Registro Completo
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Biblioteca(s): |
Embrapa Recursos Genéticos e Biotecnologia. |
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Data corrente: |
06/01/2011 |
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Data da última atualização: |
03/02/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
SANTOS, D. M.; VERLY, R. M.; PILÓ VELOSO, D.; MARIA, M. de; CARVALHO, M. A. R. de; CISALPINO, P. S.; SOARES, B. M.; DINIZ, C. G.; FARIAS, L. M.; MOREIRA, D. F. F.; FRÉZARD, F.; BEMQUERER, M. P.; PIMENTA, A. M. C.; LIMA, M. E. de. |
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Afiliação: |
MARCELO PORTO BEMQUERER, CENARGEN. |
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Título: |
LyeTx I, a potent antimicrobial peptide from the venom of the spider Lycosa erythrognatha. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
Amino Acids, v. 39, p. 135-144, 2010. |
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Idioma: |
Inglês |
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Palavras-Chave: |
Antimicrobial peptide; Lycosa erythrognatha; LyeTx I; Spider venom. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/181851/1/Santos2010-Article-LyeTxIAPotentAntimicrobialPept.pdf
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Marc: |
LEADER 00897naa a2200313 a 4500
001 1871814
005 2023-02-03
008 2010 bl uuuu u00u1 u #d
100 1 $aSANTOS, D. M.
245 $aLyeTx I, a potent antimicrobial peptide from the venom of the spider Lycosa erythrognatha.$h[electronic resource]
260 $c2010
653 $aAntimicrobial peptide
653 $aLycosa erythrognatha
653 $aLyeTx I
653 $aSpider venom
700 1 $aVERLY, R. M.
700 1 $aPILÓ VELOSO, D.
700 1 $aMARIA, M. de
700 1 $aCARVALHO, M. A. R. de
700 1 $aCISALPINO, P. S.
700 1 $aSOARES, B. M.
700 1 $aDINIZ, C. G.
700 1 $aFARIAS, L. M.
700 1 $aMOREIRA, D. F. F.
700 1 $aFRÉZARD, F.
700 1 $aBEMQUERER, M. P.
700 1 $aPIMENTA, A. M. C.
700 1 $aLIMA, M. E. de
773 $tAmino Acids$gv. 39, p. 135-144, 2010.
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Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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