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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
07/06/2019 |
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Data da última atualização: |
30/10/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LIMA, G. G. de; CHEE, B. S.; MORITZ, V. F.; CORTESE, Y. J.; MAGALHAES, W. L. E.; DEVINE, D. M.; NUGENT, M. J. D. |
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Afiliação: |
Gabriel Goetten de Lima, Materials Research Institute, Athlone Institute of Technology; Bor Shin Chee, Materials Research Institute, Athlone Institute of Technology; Vicente Froés Moritz, Materials Research Institute, Athlone Institute of Technology; Yvonne J Cortese, Materials Research Institute, Athlone Institute of Technology; WASHINGTON LUIZ ESTEVES MAGALHAES, CNPF; Declan M Devine, Materials Research Institute, Athlone Institute of Technology; Michael J D Nugent, Materials Research Institute, Athlone Institute of Technology. |
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Título: |
The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Biomedical Physics & Engineering Express, v. 5, n. 4, 045017, Jul. 2019. 13 p. |
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DOI: |
10.1088/2057-1976/ab2547 |
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Idioma: |
Inglês |
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Conteúdo: |
Although freeze-thaw mechanism for producing crosslinked hydrogels is relatively easy and simple, it lacks sufficient integrity and support leading to modifications on its three-dimensional polymeric network arrangement during water removal?drying. Therefore, a strengthening method for obtaining cryogenic spheres of polyvinyl alcohol hydrogels is purposed by dispensing it as liquid droplets into a low temperature solution followed by a modification on its freeze-thaw cycles to confer a good geometry without aggregation. Various materials were incorporated into this hydrogel structure, including poly(acrylic acid) to impart pH sensitivity; hydroxyapatite to improve biocompatibility; and ciprofloxacin as an antimicrobial agent relevant for the treatment of osteomyelitis. The overall network presented a porous structure with a fibrous-like pattern which varied in size and volume, with presence of Ca and P when hydroxyapatite is incorporated. These materials varied the crystalline melting point of the poly(vinyl alcohol) and a linear pHsensitivity function was obtained by the addition of the materials. These hydrogels were found to release ciprofloxacin within 60 min and were able to dissolve at the same time intervals. Therefore, the hydrogel synthesised in this work can be used as an immediate release drug delivery mechanism for the in situ delivery of active pharmaceutical such as ciprofloxacin for a treatment of osteomyelitis. |
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Palavras-Chave: |
Álcool polivinílico; Immediate releas; Liberação de fármaco por via oral; Oral drug delivery; PH-sensitivity; Produto madeireiro. |
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Thesaurus Nal: |
Polyvinyl alcohol. |
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Categoria do assunto: |
X Pesquisa, Tecnologia e Engenharia |
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Marc: |
LEADER 02387naa a2200289 a 4500
001 2109732
005 2019-10-30
008 2019 bl uuuu u00u1 u #d
024 7 $a10.1088/2057-1976/ab2547$2DOI
100 1 $aLIMA, G. G. de
245 $aThe production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system.$h[electronic resource]
260 $c2019
520 $aAlthough freeze-thaw mechanism for producing crosslinked hydrogels is relatively easy and simple, it lacks sufficient integrity and support leading to modifications on its three-dimensional polymeric network arrangement during water removal?drying. Therefore, a strengthening method for obtaining cryogenic spheres of polyvinyl alcohol hydrogels is purposed by dispensing it as liquid droplets into a low temperature solution followed by a modification on its freeze-thaw cycles to confer a good geometry without aggregation. Various materials were incorporated into this hydrogel structure, including poly(acrylic acid) to impart pH sensitivity; hydroxyapatite to improve biocompatibility; and ciprofloxacin as an antimicrobial agent relevant for the treatment of osteomyelitis. The overall network presented a porous structure with a fibrous-like pattern which varied in size and volume, with presence of Ca and P when hydroxyapatite is incorporated. These materials varied the crystalline melting point of the poly(vinyl alcohol) and a linear pHsensitivity function was obtained by the addition of the materials. These hydrogels were found to release ciprofloxacin within 60 min and were able to dissolve at the same time intervals. Therefore, the hydrogel synthesised in this work can be used as an immediate release drug delivery mechanism for the in situ delivery of active pharmaceutical such as ciprofloxacin for a treatment of osteomyelitis.
650 $aPolyvinyl alcohol
653 $aÁlcool polivinílico
653 $aImmediate releas
653 $aLiberação de fármaco por via oral
653 $aOral drug delivery
653 $aPH-sensitivity
653 $aProduto madeireiro
700 1 $aCHEE, B. S.
700 1 $aMORITZ, V. F.
700 1 $aCORTESE, Y. J.
700 1 $aMAGALHAES, W. L. E.
700 1 $aDEVINE, D. M.
700 1 $aNUGENT, M. J. D.
773 $tBiomedical Physics & Engineering Express$gv. 5, n. 4, 045017, Jul. 2019. 13 p.
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Registro original: |
Embrapa Florestas (CNPF) |
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Biblioteca |
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Tipo/Formato |
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Registro |
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| Registros recuperados : 25 | |
| 4. |  | LIMA, G. G. de; RUIZ, H. Z.; MATOS, M.; HELM, C. V.; LIZ, M. V. de; MAGALHAES, W. L. E. Prediction of yerba mate caffeine content using near infrared spectroscopy. Spectroscopy Letters, v. 52, n. 5, p. 282-287, 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 5. | | MALTA, D. S.; LIMA, G. G. de; LEAL, F. C.; MAROLDI, W. V.; MATHIAS, A. L.; MAGALHAES, W. L. E.; HELM, C. V.; MASSON, M. L. Enhancing the health benefits of yogurt with pinhão seed coat extract: optimization of extraction methods and in vitro bioaccessibility. Journal of Food and Nutrition Research, v. 62, n. 3, p. 199-211, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 6. | | CLARO, F. C.; LIMA, G. G. de; LIMA, T. A. M. de; HANSEL, F. A.; MATOS, M.; AVELINO, F.; OLIVEIRA, D. R.; LOMONACO, D.; MAGALHAES, W. L. E. Characterisation of laccase-mediated lignin polymerisation: implications for molecular weight, thermal stability, and electrical properties. Biomass Conversion and Biorefinery, 2023. First online.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
| Biblioteca(s): Embrapa Florestas. |
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| 7. | | LIMA, G. G. de; CHEE, B. S.; MORITZ, V. F.; CORTESE, Y. J.; MAGALHAES, W. L. E.; DEVINE, D. M.; NUGENT, M. J. D. The production of a novel poly(vinyl alcohol) hydrogel cryogenic spheres for immediate release using a droplet system. Biomedical Physics & Engineering Express, v. 5, n. 4, 045017, Jul. 2019. 13 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 3 |
| Biblioteca(s): Embrapa Florestas. |
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| 8. | | LIMA, T. A. de M. de; LIMA, G. G. de; COSTA, L. N. da; NUGENT, M.; MAGALHAES, W. L. E.; KUROMOTO, N. K. Evaluation of titanium nitride coatings in bandsaw blades for wood splitting by cold plasma. Wood Material Science & Engineering, v. 18, n. 1, p. 130-140, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 9. | | LIMA, G. G. de; FERREIRA, B. D.; MATOS, M.; PEREIRA, B. L.; NUGENT, M. J. D.; HANSEL, F. A.; MAGALHAES, W. L. E. Effect of cellulose size-concentration on the structure of polyvinyl alcohol hydrogels. Carbohydrate Polymers, v. 245, 116612, Oct. 2020. 10 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 10. | | LIMA, G. G. de; BARBOSA, R. R. C.; SANTOS, M. P. de A.; CHEE, B. S.; MAGALHAES, W. L. E.; DEVINE, D. M.; NUGENT, M. J. D. Effect of unidirectional freezing using a thermal camera on polyvinyl (alcohol) for aligned porous cryogels. Quantitative InfraRed Thermography Journal, v. 18, n. 3, p. 177-186, 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Florestas. |
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| 11. | | TIMM, T. G.; LIMA, G. G. de; MATOS, M.; MAGALHAES, W. L. E.; TAVARES, L. B. B. T.; HELM, C. V. Nanosuspension of pinhão seed coat development for a new high-functional cereal bar. Journal of Food Processing and Preservation, v. 44, n. 6, e14464, June 2020. 10 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Florestas. |
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| 12. | | LIMA, G. G. de; MATOS, M.; SÁ, F. P. de; MASHIBA, L. N.; MAGALHAES, W. L. E.; RACHWAL, M. F. G.; ZANATTA, J. A. Supraparticles as slow-release fertiliser in seedling potential growth of Eucalyptus urograndis and greenhouse gas fux impacts. Environmental Science and Pollution Research, v. 30, p. 23047-23059, 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Florestas. |
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| 13. | | LIMA, G. G. de; ELTER, J. K.; CHEE, B. S.; MAGALHAES, W. L. E.; DEVINE, D. M.; NUGENT, M. J. D.; SÁ, M. J. C. de. A tough and novel dual-response PAA/P(NiPAAM-co-PEGDMA) IPN hydrogels with ceramics by photopolymerization for consolidation of bone fragments following fracture. Biomedical Materials, v. 14, n. 5, Sept. 2019. 14 p.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 14. | | ALIABADI, M.; CHEE, B. S.; MATOS, M.; CORTESE, Y. J.; NUGENT, M. J. D.; LIMA, T. A. M. de; MAGALHAES, W. L. E.; LIMA, G. G. de. Yerba mate extract in microfibrillated cellulose and corn starch films as a potential wound healing bandage. Polymers, v. 12, 2807, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 15. | | PASKO, R. Z.; TIMM, T. G.; LIMA, G. G. de; HELM, C. V.; LIMA, E. A. de; HENRIQUES, G. S.; TAVARES, L. B. B. In vivo evaluation and nutritional quality of by-products subjected to solid-state fermentation using shiitake culinary-medicinal mushroom, Lentinula edodes (Agaricomycetes). International Journal of Medicinal Mushrooms, v. 24, n. 1, p. 53-66, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Florestas. |
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| 16. | | LOURENÇON, T. V.; LIMA, G. G. de; RIBEIRO, C. S. P.; HANSEL, F. A.; MACIEL, G. M.; SILVA, K. da; WINNISCHOFER, S. M. B.; BOLZON DE MUNIZ, G. I.; MAGALHAES, W. L. E. Antioxidant, antibacterial and antitumoural activities of kraft lignin fromhardwood fractionated by acid precipitation. International Journal of Biological Macromolecules, v. 166, p. 1535-1542, Jan. 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 17. | | MALTA, D. S.; LIMA, G. G. de; ARANTES, M. S. T.; LACERDA, A. E. B. de; MATHIAS, A. L.; MAGALHAES, W. L. E.; HELM, C. V.; MASSON, M. L. Linking geographical origin with nutritional, mineral, and visual proprieties of pinhão (Araucaria angustifolia seed) from the south of Brazil. Journal of Food Science and Technology, v. 87, n.10, p. 4738-4750, Outubro, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 3 |
| Biblioteca(s): Embrapa Florestas. |
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| 18. | | LIMA, G. G. de; MIRANDA, N. B. de; TIMM, T. G.; MATOS, M.; LIMA, T. A. M. de; MAGALHAES, W. L. E.; TAVARES, L. B. B.; HANSEL, F. A.; HELM, C. V. Characterisation and in vivo evaluation of Araucaria angustifolia pinhão seed coat nanosuspension as a functional food source. Food & Function, v. 11, p. 9820-9832, 2020.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 19. | | LIMA, T. A. de M. de; LIMA, G. G. de; CHEE, B. S.; HENN, J. G.; CORTESE, Y. J.; MATOS, M.; HELM, C. V.; MAGALHAES, W. L. E.; NUGENT, M. J. D. Characterization of gels and films produced from pinhão seed coat nanocellulose as a potential use for wound healing dressings and screening of Its compounds towards antitumour effects. Polymers, v. 14, 2776, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| 20. | | LIMA, G. G. de; WILKESIVEK, T.; MATOS, M.; THÁ, E. L.; OLIVEIRA, K. M. G. de; SOUZA, I. R. de; LIMA, T. A. de M. de; CESTARI, M. M.; MAGALHAES, W. L. E.; HANSEL, F. A.; LEME, D. M. A biocide delivery system composed of nanosilica loaded with neem oil is effective in reducing plant toxicity of this biocide. Environmental Pollution, v. 294, 118660, Feb. 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Florestas. |
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| Registros recuperados : 25 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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