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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
14/08/2020 |
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Data da última atualização: |
10/09/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
LIMA, A. O. de; KOLTES, J. E.; DINIZ, W. J. S.; OLIVEIRA, P. S. N. de; CESAR, A. S. M.; TIZIOTO, P. L.; AFONSO, J.; SOUZA, M. de S.; PETRINI, J.; ROCHA, M. I. P.; CARDOSO, T. F.; ZERLOTINI NETO, A.; COUTINHO, L. L.; MOURÃO, G. B.; REGITANO, L. C. de A. |
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Afiliação: |
ANDRESSA O. DE LIMA, UFSCar; JAMES E. KOLTES, Iowa State University; WELLISON J. S. DINIZ, UFSCar; PRISCILA S. N. DE OLIVEIRA; ALINE S. M. CESAR, Esalq/USP; POLYANA C. TIZIOTO, NGS Genomic Solution; JULIANA AFONSO, UFSCar; MARCELA M. DE SOUZA, Iowa State University; JULIANA PETRINI, UNIFAL; MARINA I. P. ROCHA, UFSCar; TAINÃ F. CARDOSO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ L. COUTINHO, Esalq/USP; GERSON B. MOURÃO, Esalq/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Potential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses. |
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Ano de publicação: |
2020 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 11, p. 1-14, Mar. 2020. |
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DOI: |
https://doi.org/10.3389/fgene.2020.00189 |
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Idioma: |
Inglês |
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Notas: |
Article 189. Na publicação: Luciana C. A. Regitano. |
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Conteúdo: |
Feed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass, and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle. |
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Palavras-Chave: |
Biomarcadores; Expressão gênica; Feed efficiency; Hub genes; Longissimus thoracis; Systems biology; WGCNA. |
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Thesagro: |
Bos Indicus. |
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Thesaurus Nal: |
Gene expression. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/215312/1/AP-Potential-biomarkers-2020.pdf
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Marc: |
LEADER 02711naa a2200421 a 4500
001 2124356
005 2020-09-10
008 2020 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.3389/fgene.2020.00189$2DOI
100 1 $aLIMA, A. O. de
245 $aPotential biomarkers for feed efficiency-related traits in nelore cattle identified by co-expression network and integrative genomics analyses.$h[electronic resource]
260 $c2020
500 $aArticle 189. Na publicação: Luciana C. A. Regitano.
520 $aFeed efficiency helps to reduce environmental impacts from livestock production, improving beef cattle profitability. We identified potential biomarkers (hub genes) for feed efficiency, by applying co-expression analysis in Longissimus thoracis RNA-Seq data from 180 Nelore steers. Six co-expression modules were associated with six feed efficiency-related traits (p-value ≤ 0.05). Within these modules, 391 hub genes were enriched for pathways as protein synthesis, muscle growth, and immune response. Trait-associated transcription factors (TFs) ELF1, ELK3, ETS1, FLI1, and TCF4, were identified with binding sites in at least one hub gene. Gene expression of CCDC80, FBLN5, SERPINF1, and OGN was associated with multiple feed efficiency-related traits (FDR ≤ 0.05) and were previously related to glucose homeostasis, oxidative stress, fat mass, and osteoblastogenesis, respectively. Potential regulatory elements were identified, integrating the hub genes with previous studies from our research group, such as the putative cis-regulatory elements (eQTLs) inferred as affecting the PCDH18 and SPARCL1 hub genes related to immune system and adipogenesis, respectively. Therefore, our analyses contribute to a better understanding of the biological mechanisms underlying feed efficiency in bovine and the hub genes disclosed can be used as biomarkers for feed efficiency-related traits in Nelore cattle.
650 $aGene expression
650 $aBos Indicus
653 $aBiomarcadores
653 $aExpressão gênica
653 $aFeed efficiency
653 $aHub genes
653 $aLongissimus thoracis
653 $aSystems biology
653 $aWGCNA
700 1 $aKOLTES, J. E.
700 1 $aDINIZ, W. J. S.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aCESAR, A. S. M.
700 1 $aTIZIOTO, P. L.
700 1 $aAFONSO, J.
700 1 $aSOUZA, M. de S.
700 1 $aPETRINI, J.
700 1 $aROCHA, M. I. P.
700 1 $aCARDOSO, T. F.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
700 1 $aMOURÃO, G. B.
700 1 $aREGITANO, L. C. de A.
773 $tFrontiers in Genetics$gv. 11, p. 1-14, Mar. 2020.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
03/03/2005 |
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Data da última atualização: |
11/07/2014 |
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Autoria: |
LOPES, C. E. V.; MOURÃO JÚNIOR, M.; ARCO-VERDE, M. F.; XAUD, H. A. M. |
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Título: |
Percepção de agricultores sobre o uso de sistemas agroflorestais na comunidade do Apiaú, Roraima. |
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Ano de publicação: |
2004 |
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Fonte/Imprenta: |
In: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p. 530-531. |
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Série: |
(Embrapa Florestas. Documentos, 98). |
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ISSN: |
1517-536X |
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Idioma: |
Português |
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Palavras-Chave: |
Apiaú; Roraima; Sistema agroflorestal. |
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Thesagro: |
Agricultura Familiar. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 00784naa a2200217 a 4500
001 1310237
005 2014-07-11
008 2004 bl uuuu u00u1 u #d
022 $a1517-536X
100 1 $aLOPES, C. E. V.
245 $aPercepção de agricultores sobre o uso de sistemas agroflorestais na comunidade do Apiaú, Roraima.
260 $c2004
490 $a(Embrapa Florestas. Documentos, 98).
650 $aAgricultura Familiar
653 $aApiaú
653 $aRoraima
653 $aSistema agroflorestal
700 1 $aMOURÃO JÚNIOR, M.
700 1 $aARCO-VERDE, M. F.
700 1 $aXAUD, H. A. M.
773 $tIn: CONGRESSO BRASILEIRO DE SISTEMAS AGROFLORESTAIS, 5., 2004, Curitiba. SAFs: desenvolvimento com proteção ambiental: anais. Colombo: Embrapa Florestas, 2004. p. 530-531.
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Embrapa Florestas (CNPF) |
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