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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
14/03/2017 |
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Data da última atualização: |
14/03/2017 |
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Autoria: |
KONO, Y.; ARAI, K.; SENTSUI, H.; MATSUKAWA, S. I.; ITOHARA, S. |
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Título: |
Protection against bovine leukemia virus infection in sheep by active and passive immunization. |
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Ano de publicação: |
1986 |
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Fonte/Imprenta: |
Japanese Journal of Veterinary Science v. 48, n. 1, p. 117-126, Feb. 1986. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The protective effect of active and passive immunization against bovine leukemia virus (BLV) infection was tested in sheep. Eight sheep were immunized 3 times at 2-week interval with concentrated BLV antigen treated with Triton X-100. Two weeks after the last immunization, when antibody titers to glycoprotein (gp) (gp antibody) were 32 to 256, 4 of the 8 immunized sheep were challenged with infected sheep blood and remained uninfected. These 8 sheep were challenged or rechallenged when their gp antibody titers fell to 1 to 8, and all animals were infected. Of 10 sheep immunized passively with various doses of immunoglobulin obtained from infected sheep serum, animals that had gp antibody titers of 64 showed protection against challenge inoculation. To sum up the relationship between serum antibody titers and protective effect, all sheep that had gp antibody titers of 64 or more and half the sheep that had titers of 32 showed resistance to infection. Resistance was observed in only one of the 13 sheep that had titers of 16 or less. |
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Palavras-Chave: |
Leukaemia. |
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Thesagro: |
Leucemia; Ovino. |
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Thesaurus Nal: |
Sheep. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 01654naa a2200217 a 4500
001 2067019
005 2017-03-14
008 1986 bl uuuu u00u1 u #d
100 1 $aKONO, Y.
245 $aProtection against bovine leukemia virus infection in sheep by active and passive immunization.
260 $c1986
520 $aAbstract: The protective effect of active and passive immunization against bovine leukemia virus (BLV) infection was tested in sheep. Eight sheep were immunized 3 times at 2-week interval with concentrated BLV antigen treated with Triton X-100. Two weeks after the last immunization, when antibody titers to glycoprotein (gp) (gp antibody) were 32 to 256, 4 of the 8 immunized sheep were challenged with infected sheep blood and remained uninfected. These 8 sheep were challenged or rechallenged when their gp antibody titers fell to 1 to 8, and all animals were infected. Of 10 sheep immunized passively with various doses of immunoglobulin obtained from infected sheep serum, animals that had gp antibody titers of 64 showed protection against challenge inoculation. To sum up the relationship between serum antibody titers and protective effect, all sheep that had gp antibody titers of 64 or more and half the sheep that had titers of 32 showed resistance to infection. Resistance was observed in only one of the 13 sheep that had titers of 16 or less.
650 $aSheep
650 $aLeucemia
650 $aOvino
653 $aLeukaemia
700 1 $aARAI, K.
700 1 $aSENTSUI, H.
700 1 $aMATSUKAWA, S. I.
700 1 $aITOHARA, S.
773 $tJapanese Journal of Veterinary Science$gv. 48, n. 1, p. 117-126, Feb. 1986.
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Embrapa Caprinos e Ovinos (CNPC) |
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