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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
09/06/2017 |
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Data da última atualização: |
09/06/2017 |
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Autoria: |
MATHIESON, R. A.; KITTS, W. D. |
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Título: |
Binding of phyto-oestrogen and oestradiol-17 beta by cytoplasmic receptors in the pituitary gland and hypothalamus of the ewe. |
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Ano de publicação: |
1980 |
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Fonte/Imprenta: |
Journal of Endocrinology, v. 85, n. 2, p. 317-325, Apr. 1980. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The binding of the phyto-oestrogens, genistein and coumestrol by oestrogen receptors in pituitary and hypothalamic cytosol of the ewe was studied in relation to the binding of [3H]-oestradiol-17 beta. It was determined that the interaction of these compounds was competitive. The apparent dissociation constant for oestradiol-17 beta in ewe pituitary cytosol was determined to be 0 x 26 +/- 0 x 12 (S.E.M.) nmol/l. Apparent inhibition constants for coumestrol and genistein were determined to be 60 and 170 nmol/l respectively. These results suggested that phyto-oestrogens can interfere with the normal oestrogen feedback mechanisms with respect to release of gonadotrophine in the ewe. |
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Palavras-Chave: |
Chemical Phenomena; Oestrogens; Releasing hormones. |
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Thesaurus Nal: |
coumestrol; cytosol; Estrogens; Ewes; Genistein; Hypothalamus; Pituitary gland; receptors; Sheep. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 01470naa a2200277 a 4500
001 2070662
005 2017-06-09
008 1980 bl uuuu u00u1 u #d
100 1 $aMATHIESON, R. A.
245 $aBinding of phyto-oestrogen and oestradiol-17 beta by cytoplasmic receptors in the pituitary gland and hypothalamus of the ewe.
260 $c1980
520 $aAbstract: The binding of the phyto-oestrogens, genistein and coumestrol by oestrogen receptors in pituitary and hypothalamic cytosol of the ewe was studied in relation to the binding of [3H]-oestradiol-17 beta. It was determined that the interaction of these compounds was competitive. The apparent dissociation constant for oestradiol-17 beta in ewe pituitary cytosol was determined to be 0 x 26 +/- 0 x 12 (S.E.M.) nmol/l. Apparent inhibition constants for coumestrol and genistein were determined to be 60 and 170 nmol/l respectively. These results suggested that phyto-oestrogens can interfere with the normal oestrogen feedback mechanisms with respect to release of gonadotrophine in the ewe.
650 $acoumestrol
650 $acytosol
650 $aEstrogens
650 $aEwes
650 $aGenistein
650 $aHypothalamus
650 $aPituitary gland
650 $areceptors
650 $aSheep
653 $aChemical Phenomena
653 $aOestrogens
653 $aReleasing hormones
700 1 $aKITTS, W. D.
773 $tJournal of Endocrinology$gv. 85, n. 2, p. 317-325, Apr. 1980.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
