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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
09/02/1996 |
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Data da última atualização: |
09/02/1996 |
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Autoria: |
DINEEN, J. K.; GREGG, P.; WINDON, R. G.; DONALD, A. D.; KELLY, J. D. |
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Título: |
The role of immunologically specific and non-specific components of resistance in cross-protection to intestinal nematodes. |
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Ano de publicação: |
1977 |
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Fonte/Imprenta: |
International Journal for Parasitology, v.7, n.3, p.211-215, 1977. |
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Idioma: |
Inglês |
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Conteúdo: |
Vaccination of 6-8-month-old Merino sheep with irradiated Trichostrongylus colubriformis larvae gave a high level of protection (81%) against single-species challenge with normal infective larvae of the same species. The level of protection (34%) was substantially redu-
ced against challenge with a closely related species (T. vitrinus) and no significant protec-
tion occurred against single-species challenge with a generically unrelated nematode (Ne-
matodirus spathiger). These results suggest that antigen(s) which stimaulate protective im-
munity are shared by the related Trichostrongylus species but not by N. spathiger. By con-
trast with the results obtained for single-species challenge, vaccination with irradiated T. colubriformis produced 98-100% protection against all 3 species in animals challenged si-
multaneously with infective larvae of the 3 species. Comparison of the levels of protection recorded following the 2 types of challenge indicate that although a specific antigenic trigger is required to provoke an appropriate response, the reults obtained, particularly in the case of N. spathiger, suggest that the terminal effector mechanisms is not immunologi-
cal specific. The implications of thse conclusions are discussed in relation the theories of the mechanism of resistance to gastrointestinal nematodes and the potential efficacy of vaccination in the field. |
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Palavras-Chave: |
Cross-protection; Immunological specificity; Intestinal nematode; Parasita; Parasite; Resistance; Resistancia; T; vitrinus. |
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Thesagro: |
Imunologia; Intestino; Nematóide. |
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Thesaurus Nal: |
Nematodirus spathiger; Trichostrongylus colubriformis. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02343naa a2200337 a 4500
001 1787207
005 1996-02-09
008 1977 bl --- 0-- u #d
100 1 $aDINEEN, J. K.
245 $aThe role of immunologically specific and non-specific components of resistance in cross-protection to intestinal nematodes.
260 $c1977
520 $aVaccination of 6-8-month-old Merino sheep with irradiated Trichostrongylus colubriformis larvae gave a high level of protection (81%) against single-species challenge with normal infective larvae of the same species. The level of protection (34%) was substantially redu- ced against challenge with a closely related species (T. vitrinus) and no significant protec- tion occurred against single-species challenge with a generically unrelated nematode (Ne- matodirus spathiger). These results suggest that antigen(s) which stimaulate protective im- munity are shared by the related Trichostrongylus species but not by N. spathiger. By con- trast with the results obtained for single-species challenge, vaccination with irradiated T. colubriformis produced 98-100% protection against all 3 species in animals challenged si- multaneously with infective larvae of the 3 species. Comparison of the levels of protection recorded following the 2 types of challenge indicate that although a specific antigenic trigger is required to provoke an appropriate response, the reults obtained, particularly in the case of N. spathiger, suggest that the terminal effector mechanisms is not immunologi- cal specific. The implications of thse conclusions are discussed in relation the theories of the mechanism of resistance to gastrointestinal nematodes and the potential efficacy of vaccination in the field.
650 $aNematodirus spathiger
650 $aTrichostrongylus colubriformis
650 $aImunologia
650 $aIntestino
650 $aNematóide
653 $aCross-protection
653 $aImmunological specificity
653 $aIntestinal nematode
653 $aParasita
653 $aParasite
653 $aResistance
653 $aResistancia
653 $aT
653 $avitrinus
700 1 $aGREGG, P.
700 1 $aWINDON, R. G.
700 1 $aDONALD, A. D.
700 1 $aKELLY, J. D.
773 $tInternational Journal for Parasitology$gv.7, n.3, p.211-215, 1977.
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Registro original: |
Embrapa Pantanal (CPAP) |
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