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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
28/08/1995 |
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Data da última atualização: |
12/01/2009 |
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Autoria: |
HALL, C. A.; KELLY, J. D.; CAMPBELL, N. J.; WHITLOCK, H. V.; MARTIN, I. C. A. |
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Título: |
The dose response of several benzimidazole anthelmintics against resistant stains of Haemonchus contortus and Trichostronngylus colubriformis selected with thiabendazole. |
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Ano de publicação: |
1978 |
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Fonte/Imprenta: |
Research in Veterinary Science, v.25, n.3, p.364-367, 1978. |
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Idioma: |
Inglês |
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Conteúdo: |
Doses responses lines for eight benzimidazole anthelmintics and thiophanate were deter-
mined, using standardised strains of thiabendazole selected and resistant Haemonchus
contortus and trichostrongylus colubriformis. Against H contortus, thiophanate, thiabenda-
zole, parbendazole oxibendazole were inactive. Mebendazole was inactive at dose rates of 6.26 and 12.5 mg/kg, although significantly activity occurred at 25 mg/kg. Fenbenda-
zole, cambendazole, oxfendazole and albendazole demonstrated significant activity at
dose rates equal to or greater than the recommended therapetic level. Thiophanate was
inactive against resistant T colubriformis. The remaining compounds only showed signifi-
cant activity when used at dose rates in excess of the recommended therapeutic level.
These results show that a side resistante exists among the benzimidazole anthelmintics
and suggests that changes in dose response lines could be expected to occur if resistant
strains are selected with benzimidazoles other than thiabendazole. |
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Palavras-Chave: |
Antehelmintico; Parasita; Parasite; Resistant. |
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Thesagro: |
Haemonchus Contortus; Resistência. |
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Thesaurus Nal: |
anthelmintics; benzimidazole; thiabendazole; Trichostrongylus colubriformis. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01913naa a2200289 a 4500
001 1785885
005 2009-01-12
008 1978 bl --- 0-- u #d
100 1 $aHALL, C. A.
245 $aThe dose response of several benzimidazole anthelmintics against resistant stains of Haemonchus contortus and Trichostronngylus colubriformis selected with thiabendazole.
260 $c1978
520 $aDoses responses lines for eight benzimidazole anthelmintics and thiophanate were deter- mined, using standardised strains of thiabendazole selected and resistant Haemonchus contortus and trichostrongylus colubriformis. Against H contortus, thiophanate, thiabenda- zole, parbendazole oxibendazole were inactive. Mebendazole was inactive at dose rates of 6.26 and 12.5 mg/kg, although significantly activity occurred at 25 mg/kg. Fenbenda- zole, cambendazole, oxfendazole and albendazole demonstrated significant activity at dose rates equal to or greater than the recommended therapetic level. Thiophanate was inactive against resistant T colubriformis. The remaining compounds only showed signifi- cant activity when used at dose rates in excess of the recommended therapeutic level. These results show that a side resistante exists among the benzimidazole anthelmintics and suggests that changes in dose response lines could be expected to occur if resistant strains are selected with benzimidazoles other than thiabendazole.
650 $aanthelmintics
650 $abenzimidazole
650 $athiabendazole
650 $aTrichostrongylus colubriformis
650 $aHaemonchus Contortus
650 $aResistência
653 $aAntehelmintico
653 $aParasita
653 $aParasite
653 $aResistant
700 1 $aKELLY, J. D.
700 1 $aCAMPBELL, N. J.
700 1 $aWHITLOCK, H. V.
700 1 $aMARTIN, I. C. A.
773 $tResearch in Veterinary Science$gv.25, n.3, p.364-367, 1978.
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Registro original: |
Embrapa Pantanal (CPAP) |
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