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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
16/12/2003 |
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Data da última atualização: |
10/08/2023 |
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Autoria: |
KALRA, S. P.; DUBE, M. G.; SAHU, A.; PHELPS, C. P.; KALRA, P. S. |
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Título: |
Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. |
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Ano de publicação: |
1991 |
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Fonte/Imprenta: |
Proceedings National Academy Science, v. 88, n. 23, p. 10931-10935, Dec. 1991. |
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DOI: |
10.1073/pnas.88.23.10931 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Feeding in mammals is a periodic behavior; however, knowledge of how the brain signals an intermittent eating pattern is scanty. Recent indirect evidence indicates that one of the signals encoded in the structure of neuropeptide Y (NPY) is to stimulate robust feeding. Therefore, two series of experiments were undertaken to characterize NPY secretion within the paraventricular nucleus (PVN) in association with eating behavior in the rat. Dynamic changes in NPY concentration in several hypothalamic sites and release in the PVN were assessed before and during the course of food consumption in rats trained to eat daily only for 4 h. Only in the PVN were NPY concentrations elevated before the introduction of food and, thereafter, levels decreased significantly during the course of eating. A similar temporal pattern in NPY release into the PVN interstitium was evident in samples collected by push-pull cannula perfusion in unrestrained rats. In addition, in food-deprived rats displaying a robust drive for feeding, NPY release in the PVN was also markedly enhanced in the shape of high-amplitude secretory episodes as compared to a lower release rate in rats receiving food ad libitum. The higher rate of NPY release in fasted rats returned to the control range after 24 h of ad libitum food supply. These findings of intense and dynamic NPY neurosecretory activity within a discrete hypothalamic site in association with an increased drive for food consumption demonstrate that NPY release in the PVN is an important orexigenic signal for periodic eating behavior. These results have important global implications for elucidating the underlying causes of the pathophysiology of eating disorders--anorexia nervosa, bulimia, and obesity--as well as constituting a specific contextual model for the formulation and testing of suitable NPY receptor agonists and antagonists for therapeutic intervention. MenosAbstract: Feeding in mammals is a periodic behavior; however, knowledge of how the brain signals an intermittent eating pattern is scanty. Recent indirect evidence indicates that one of the signals encoded in the structure of neuropeptide Y (NPY) is to stimulate robust feeding. Therefore, two series of experiments were undertaken to characterize NPY secretion within the paraventricular nucleus (PVN) in association with eating behavior in the rat. Dynamic changes in NPY concentration in several hypothalamic sites and release in the PVN were assessed before and during the course of food consumption in rats trained to eat daily only for 4 h. Only in the PVN were NPY concentrations elevated before the introduction of food and, thereafter, levels decreased significantly during the course of eating. A similar temporal pattern in NPY release into the PVN interstitium was evident in samples collected by push-pull cannula perfusion in unrestrained rats. In addition, in food-deprived rats displaying a robust drive for feeding, NPY release in the PVN was also markedly enhanced in the shape of high-amplitude secretory episodes as compared to a lower release rate in rats receiving food ad libitum. The higher rate of NPY release in fasted rats returned to the control range after 24 h of ad libitum food supply. These findings of intense and dynamic NPY neurosecretory activity within a discrete hypothalamic site in association with an increased drive for food consumption demonstrate that NP... Mostrar Tudo |
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Palavras-Chave: |
Feeding habits; Neuropepitídeo; Opioide; Reference Values; Stereotaxic Techniques. |
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Thesagro: |
Consumo Alimentar; Endocrinologia; Peptídeo; Rato. |
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Thesaurus Nal: |
Appetite; Endocrinology; Feeding behavior; Food deprivation; Hormone metabolism; Neuropeptide Y; Paraventricular hypothalamic nucleus; Physiology; Radioimmunoassays; Rats. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 03107naa a2200409 a 4500
001 1530071
005 2023-08-10
008 1991 bl uuuu u00u1 u #d
024 7 $a10.1073/pnas.88.23.10931$2DOI
100 1 $aKALRA, S. P.
245 $aNeuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food.$h[electronic resource]
260 $c1991
520 $aAbstract: Feeding in mammals is a periodic behavior; however, knowledge of how the brain signals an intermittent eating pattern is scanty. Recent indirect evidence indicates that one of the signals encoded in the structure of neuropeptide Y (NPY) is to stimulate robust feeding. Therefore, two series of experiments were undertaken to characterize NPY secretion within the paraventricular nucleus (PVN) in association with eating behavior in the rat. Dynamic changes in NPY concentration in several hypothalamic sites and release in the PVN were assessed before and during the course of food consumption in rats trained to eat daily only for 4 h. Only in the PVN were NPY concentrations elevated before the introduction of food and, thereafter, levels decreased significantly during the course of eating. A similar temporal pattern in NPY release into the PVN interstitium was evident in samples collected by push-pull cannula perfusion in unrestrained rats. In addition, in food-deprived rats displaying a robust drive for feeding, NPY release in the PVN was also markedly enhanced in the shape of high-amplitude secretory episodes as compared to a lower release rate in rats receiving food ad libitum. The higher rate of NPY release in fasted rats returned to the control range after 24 h of ad libitum food supply. These findings of intense and dynamic NPY neurosecretory activity within a discrete hypothalamic site in association with an increased drive for food consumption demonstrate that NPY release in the PVN is an important orexigenic signal for periodic eating behavior. These results have important global implications for elucidating the underlying causes of the pathophysiology of eating disorders--anorexia nervosa, bulimia, and obesity--as well as constituting a specific contextual model for the formulation and testing of suitable NPY receptor agonists and antagonists for therapeutic intervention.
650 $aAppetite
650 $aEndocrinology
650 $aFeeding behavior
650 $aFood deprivation
650 $aHormone metabolism
650 $aNeuropeptide Y
650 $aParaventricular hypothalamic nucleus
650 $aPhysiology
650 $aRadioimmunoassays
650 $aRats
650 $aConsumo Alimentar
650 $aEndocrinologia
650 $aPeptídeo
650 $aRato
653 $aFeeding habits
653 $aNeuropepitídeo
653 $aOpioide
653 $aReference Values
653 $aStereotaxic Techniques
700 1 $aDUBE, M. G.
700 1 $aSAHU, A.
700 1 $aPHELPS, C. P.
700 1 $aKALRA, P. S.
773 $tProceedings National Academy Science$gv. 88, n. 23, p. 10931-10935, Dec. 1991.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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