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Registro Completo |
Biblioteca(s): |
Ebooks. |
Data corrente: |
01/02/2013 |
Data da última atualização: |
01/02/2013 |
Autoria: |
NEVE, K. A. |
Afiliação: |
Kim A. Neve. |
Título: |
The Dopamine Receptors. |
Ano de publicação: |
2010 |
Fonte/Imprenta: |
Springer eBooks. |
Páginas: |
XII, 648p. 69 illus., 6 illus. in color. |
Descrição Física: |
digital. |
Série: |
The Receptors |
ISBN: |
9781603273336 |
DOI: |
10.1007/978-1-60327-333-6 |
Idioma: |
Inglês |
Conteúdo: |
Historical Overview/Introduction to the Dopamine Receptors -- Gene and Promoter Structures of the Dopamine Receptors -- Structural Basis of Dopamine Receptor Activation and Function -- Dopamine Receptor Subtype-Selective Drugs: D2-like Receptors -- Dopamine Receptor Subtype-Selective Drugs: D1-like Receptors -- Dopamine Receptor Signaling: Intracellular Pathways to Behavior -- Dopamine Receptor Signaling: Physiology -- Regulation of Dopamine Receptor Trafficking and Responsiveness -- Dopamine Receptor Interacting Proteins (DRIPS) -- Dopamine Receptor Oligomerization -- Dopamine Receptor Knockout mice -- Dopamine Receptors and Behavior -- Imaging Dopamine Receptors in Normal and Disease States -- Dopamine Receptor Modulation of Glutamatergic Neurotransmission -- Dopamine Receptors and the Treatment of Schizophrenia -- Dopamine Receptors and Cortical/Cognitive Function -- Dopamine Receptors and Reward/Addiction -- Genetic Association of Dopamine Receptors with Neuropsychiatric Disorders. .Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors. This second edition of Dopamine Receptors will be of interest to neurobiologists, pharmacologists and molecular biologists who study the brain, as well as neurologists working on psychiatric diseases. MenosHistorical Overview/Introduction to the Dopamine Receptors -- Gene and Promoter Structures of the Dopamine Receptors -- Structural Basis of Dopamine Receptor Activation and Function -- Dopamine Receptor Subtype-Selective Drugs: D2-like Receptors -- Dopamine Receptor Subtype-Selective Drugs: D1-like Receptors -- Dopamine Receptor Signaling: Intracellular Pathways to Behavior -- Dopamine Receptor Signaling: Physiology -- Regulation of Dopamine Receptor Trafficking and Responsiveness -- Dopamine Receptor Interacting Proteins (DRIPS) -- Dopamine Receptor Oligomerization -- Dopamine Receptor Knockout mice -- Dopamine Receptors and Behavior -- Imaging Dopamine Receptors in Normal and Disease States -- Dopamine Receptor Modulation of Glutamatergic Neurotransmission -- Dopamine Receptors and the Treatment of Schizophrenia -- Dopamine Receptors and Cortical/Cognitive Function -- Dopamine Receptors and Reward/Addiction -- Genetic Association of Dopamine Receptors with Neuropsychiatric Disorders. .Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled ma... Mostrar Tudo |
Palavras-Chave: |
Biomedicine; Neurobiology; Neurology; Neurosciences; Pharmaceutical Sciences/Technology; Pharmaceutical technology; Pharmacology/Toxicology. |
Thesaurus Nal: |
human physiology; medicine; toxicology. |
Categoria do assunto: |
-- |
URL: |
https://dx.doi.org/10.1007/978-1-60327-333-6
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Marc: |
LEADER 03128nam a2200277 a 4500 001 1947711 005 2013-02-01 008 2010 bl uuuu u0uu1 u #d 020 $a9781603273336 024 7 $a10.1007/978-1-60327-333-6$2DOI 100 1 $aNEVE, K. A. 245 $aThe Dopamine Receptors.$h[electronic resource] 260 $aSpringer eBooks.$c2010 300 $aXII, 648p. 69 illus., 6 illus. in color.$cdigital. 490 $aThe Receptors 520 $a<P>Historical Overview/Introduction to the Dopamine Receptors -- Gene and Promoter Structures of the Dopamine Receptors -- Structural Basis of Dopamine Receptor Activation and Function -- Dopamine Receptor Subtype-Selective Drugs: D2-like Receptors -- Dopamine Receptor Subtype-Selective Drugs: D1-like Receptors -- Dopamine Receptor Signaling: Intracellular Pathways to Behavior -- Dopamine Receptor Signaling: Physiology -- Regulation of Dopamine Receptor Trafficking and Responsiveness -- Dopamine Receptor Interacting Proteins (DRIPS) -- Dopamine Receptor Oligomerization -- Dopamine Receptor Knockout mice -- Dopamine Receptors and Behavior -- Imaging Dopamine Receptors in Normal and Disease States -- Dopamine Receptor Modulation of Glutamatergic Neurotransmission -- Dopamine Receptors and the Treatment of Schizophrenia -- Dopamine Receptors and Cortical/Cognitive Function -- Dopamine Receptors and Reward/Addiction -- Genetic Association of Dopamine Receptors with Neuropsychiatric Disorders.</P>.<P>Dopamine receptors are among the most validated drug targets for neuropsychiatric disorders such as schizophrenia and Parkinson’s disease, and are potential targets for other disorders such as substance abuse, depression, Tourette’s syndrome, and attention deficit hyperactivity disorder. The new knowledge brought from the creation and characterization of mice deficient in each of the subtypes and the development of increasingly subtype-selective agonists and antagonists has fueled many of the chapters new to this second edition, with the use of knock-out mice and subtype-selective drugs meriting discussion in stand-alone chapters. The field of G protein-coupled receptors has also advanced significantly since the first edition, with a model of GPCR signaling based on linear, compartmentalized pathways having been replaced by a more complex, richer model in which neurotransmitter effects are mediated by a signalplex composed of numerous signaling proteins, including multiple GPCRs, other types of receptors, such as ionotropic receptors, accessory and scaffolding proteins, and effectors. This second edition of <EM>Dopamine Receptors </EM>will be of interest to neurobiologists, pharmacologists and molecular biologists who study the brain, as well as neurologists working on psychiatric diseases.</P> 650 $ahuman physiology 650 $amedicine 650 $atoxicology 653 $aBiomedicine 653 $aNeurobiology 653 $aNeurology 653 $aNeurosciences 653 $aPharmaceutical Sciences/Technology 653 $aPharmaceutical technology 653 $aPharmacology/Toxicology
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