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Registro Completo |
Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
Data corrente: |
11/09/2018 |
Data da última atualização: |
11/09/2018 |
Autoria: |
MCHARDY, N.; WOOLLON, R. M.; CLAMPITT, R. B.; JAMES, J. A.; CRAWLEY, R. J. |
Título: |
Efficacy, toxicity and metabolism of imidocarb dipropionate in the treatment of Babesia ovis infection in sheep. |
Ano de publicação: |
1986 |
Fonte/Imprenta: |
Research in Veterinary Science, v. 41, n. 1, p. 14-20, Jul. 1986. |
Idioma: |
Inglês |
Conteúdo: |
Abstract: An intramuscular dose of 1.2 mg kg-1 of imidocarb dipropionate (IMDP) was effective in controlling fatal infections with Babesia ovis in sheep. The sheep were infected by the intravenous injection of sheep blood containing B ovis. A severe recrudescence of infection occurred in most sheep 10 to 14 days after therapy but this could be controlled by a second dose of 1.2 mg kg-1 IMDP. Studies on the toxicology, residues and metabolism of IMDP showed this to be a safe dosage regimen. Transient or mild signs of toxicity were seen at 2.4 and 4.8 mg kg-1 IMDP. Severe toxicity was observed in sheep treated with 9.6 mg kg-1. |
Palavras-Chave: |
Imidocarb dipropionate. |
Thesaurus Nal: |
Babesiosis; Blood; Creatinine; Drug evaluation; Drug therapy; Imidocarb; Magnesium; Parasitology; Sheep diseases; Urea. |
Categoria do assunto: |
H Saúde e Patologia |
Marc: |
LEADER 01464naa a2200301 a 4500 001 2095389 005 2018-09-11 008 1986 bl uuuu u00u1 u #d 100 1 $aMCHARDY, N. 245 $aEfficacy, toxicity and metabolism of imidocarb dipropionate in the treatment of Babesia ovis infection in sheep. 260 $c1986 520 $aAbstract: An intramuscular dose of 1.2 mg kg-1 of imidocarb dipropionate (IMDP) was effective in controlling fatal infections with Babesia ovis in sheep. The sheep were infected by the intravenous injection of sheep blood containing B ovis. A severe recrudescence of infection occurred in most sheep 10 to 14 days after therapy but this could be controlled by a second dose of 1.2 mg kg-1 IMDP. Studies on the toxicology, residues and metabolism of IMDP showed this to be a safe dosage regimen. Transient or mild signs of toxicity were seen at 2.4 and 4.8 mg kg-1 IMDP. Severe toxicity was observed in sheep treated with 9.6 mg kg-1. 650 $aBabesiosis 650 $aBlood 650 $aCreatinine 650 $aDrug evaluation 650 $aDrug therapy 650 $aImidocarb 650 $aMagnesium 650 $aParasitology 650 $aSheep diseases 650 $aUrea 653 $aImidocarb dipropionate 700 1 $aWOOLLON, R. M. 700 1 $aCLAMPITT, R. B. 700 1 $aJAMES, J. A. 700 1 $aCRAWLEY, R. J. 773 $tResearch in Veterinary Science$gv. 41, n. 1, p. 14-20, Jul. 1986.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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