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Registro Completo |
Biblioteca(s): |
Embrapa Florestas; Embrapa Recursos Genéticos e Biotecnologia. |
Data corrente: |
17/05/2017 |
Data da última atualização: |
31/03/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
RESENDE, R. T.; RESENDE, M. D. V. de; SILVA, F. F. S.; AZEVEDO, C. F. A.; TAKAHASHI, E. K. T.; SILVA JUNIOR, O. B. da; GRATTAPAGLIA, D. |
Afiliação: |
RAFAEL TASSINARI RESENDE, UNIVERSIDADE FEDERAL DE VIÇOSA; MARCOS DEON VILELA DE RESENDE, CNPF; FABYANO FONSECA SILVA, UNIVERSIDADE FEDERAL DE VIÇOSA; CAMILA FERREIRA AZEVEDO, UNIVERSIDADE FEDERAL DE VIÇOSA; ELIZABETE KEIKO TAKAHASHI, CENIBRA CELULOSE NIPO BRASILEIRA S.A; ORZENIL BONFIM DA SILVA JUNIOR, Cenargen; DARIO GRATTAPAGLIA, Cenargen. |
Título: |
Regional heritability mapping and genome-wide association identify loci for complex growth, wood and disease resistance traits in Eucalyptus. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
New Phytologist, v. 213, p. 1287-1300, 2017. |
DOI: |
10.1111/nph.14266 |
Idioma: |
Inglês |
Conteúdo: |
Although genome-wide association studies (GWAS) have provided valuable insights into the decoding of the relationships between sequence variation and complex phenotypes, they have explained little heritability. Regional heritability mapping (RHM) provides heritability estimates for genomic segments containing both common and rare allelic effects that individually contribute too little variance to be detected by GWAS. We carried out GWAS and RHM for seven growth, wood and disease resistance traits in a breeding population of 768 Eucalyptus hybrid trees using EuCHIP60K. Total genomic heritabilities accounted for large proportions (64?89%) of pedigree-based trait heritabilities, providing additional evidence that complex traits in eucalypts are controlled by many sequence variants across the frequency spectrum, each with small contributions to the phenotypic variance. RHM detected 26 quantitative trait loci (QTLs) encompassing 2191 single nucleotide polymorphisms (SNPs), whereas GWAS detected 13 single SNP?trait associations. RHM and GWAS QTLs individually explained 5?15% and 4?6% of the genomic heritability, respectively. RHM was superior to GWAS in capturing larger proportions of genomic heritability. Equated to previously mapped QTLs, our results highlighted genomic regions for further examination towards gene discovery. RHM-QTLs bearing a combination of common and rare variants could be useful enhancements to incorporate prior knowledge of the underlying genetic architecture in genomic prediction mode MenosAlthough genome-wide association studies (GWAS) have provided valuable insights into the decoding of the relationships between sequence variation and complex phenotypes, they have explained little heritability. Regional heritability mapping (RHM) provides heritability estimates for genomic segments containing both common and rare allelic effects that individually contribute too little variance to be detected by GWAS. We carried out GWAS and RHM for seven growth, wood and disease resistance traits in a breeding population of 768 Eucalyptus hybrid trees using EuCHIP60K. Total genomic heritabilities accounted for large proportions (64?89%) of pedigree-based trait heritabilities, providing additional evidence that complex traits in eucalypts are controlled by many sequence variants across the frequency spectrum, each with small contributions to the phenotypic variance. RHM detected 26 quantitative trait loci (QTLs) encompassing 2191 single nucleotide polymorphisms (SNPs), whereas GWAS detected 13 single SNP?trait associations. RHM and GWAS QTLs individually explained 5?15% and 4?6% of the genomic heritability, respectively. RHM was superior to GWAS in capturing larger proportions of genomic heritability. Equated to previously mapped QTLs, our results highlighted genomic regions for further examination towards gene discovery. RHM-QTLs bearing a combination of common and rare variants could be useful enhancements to incorporate prior knowledge of the underlying genetic architectur... Mostrar Tudo |
Thesaurus Nal: |
Eucalyptus. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/159955/1/Resende-et-al-2017-New-Phytologist.pdf
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Marc: |
LEADER 02237naa a2200217 a 4500 001 2074137 005 2023-03-31 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1111/nph.14266$2DOI 100 1 $aRESENDE, R. T. 245 $aRegional heritability mapping and genome-wide association identify loci for complex growth, wood and disease resistance traits in Eucalyptus.$h[electronic resource] 260 $c2017 520 $aAlthough genome-wide association studies (GWAS) have provided valuable insights into the decoding of the relationships between sequence variation and complex phenotypes, they have explained little heritability. Regional heritability mapping (RHM) provides heritability estimates for genomic segments containing both common and rare allelic effects that individually contribute too little variance to be detected by GWAS. We carried out GWAS and RHM for seven growth, wood and disease resistance traits in a breeding population of 768 Eucalyptus hybrid trees using EuCHIP60K. Total genomic heritabilities accounted for large proportions (64?89%) of pedigree-based trait heritabilities, providing additional evidence that complex traits in eucalypts are controlled by many sequence variants across the frequency spectrum, each with small contributions to the phenotypic variance. RHM detected 26 quantitative trait loci (QTLs) encompassing 2191 single nucleotide polymorphisms (SNPs), whereas GWAS detected 13 single SNP?trait associations. RHM and GWAS QTLs individually explained 5?15% and 4?6% of the genomic heritability, respectively. RHM was superior to GWAS in capturing larger proportions of genomic heritability. Equated to previously mapped QTLs, our results highlighted genomic regions for further examination towards gene discovery. RHM-QTLs bearing a combination of common and rare variants could be useful enhancements to incorporate prior knowledge of the underlying genetic architecture in genomic prediction mode 650 $aEucalyptus 700 1 $aRESENDE, M. D. V. de 700 1 $aSILVA, F. F. S. 700 1 $aAZEVEDO, C. F. A. 700 1 $aTAKAHASHI, E. K. T. 700 1 $aSILVA JUNIOR, O. B. da 700 1 $aGRATTAPAGLIA, D. 773 $tNew Phytologist$gv. 213, p. 1287-1300, 2017.
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Registro original: |
Embrapa Recursos Genéticos e Biotecnologia (CENARGEN) |
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Registros recuperados : 114 | |
5. | | RESENDE, R. T.; SILVA JUNIOR, O. B.; GRATTAPAGLIA, D. ENVIROTYPING in forest tree breeding: exploitation of genotype by environment interaction to avoid misallocation of genotypes in field deployment. Pesquisa Florestal Brasileira, Colombo, v. 39, (nesp), e201902043, 2019. p. 313-314. Edição especial dos resumos do IUFRO World Congress, 25., 2019, Curitiba.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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7. | | SILVA-JUNIOR, O. B.; GRATTAPAGLIA, D.; NOVAES, E.; COLLEVATTI, R. G. Genome assembly of the Pink Ipê (Handroanthus impetiginosus, Bignoniaceae), a highly valued, ecologically keystone Neotropical timber forest tree. GigaScience, v. 7, p. 1-16, 2018.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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8. | | TANNO, P.; SILVA JUNIOR, O. B. da; RESENDE, L. V.; SOUSA, V. A. de; GRATTAPAGLIA, D. A genotyping array of 3,400 Single Nucleotide Polymorphisms (SNPs) advances the genetic analysis of the iconic tree Araucaria angustifolia, showing that the natural populations ar e more differentiated than previously reported. Pesquisa Florestal Brasileira, Colombo, v. 39, (nesp), e201902043, 2019. p. 188. Edição especial dos resumos do IUFRO World Congress, 25., 2019, Curitiba.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Florestas. |
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12. | | SILVA JUNIOR, O. B.; LIRA, M.; BUSO, G. S. C.; AMARAL, Z. P. S.; GRATTAPAGLIA, D. Descoberta e genotipagem de SNPs em cajueiro via sequencimento de representações genômicas reduzidas. In. CONGRESSO BRASILEIRO DE RECURSOS GENÉTICOS, 3., 2014, Santos. Anais... Brasília, DF: Sociedade Brasileira de Recursos Genéticos, 2014. Resumo. 658. 1 CD-ROM.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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16. | | CARNEIRO, F. de A.; MARRACCINI, P.; SILVA JUNIOR, O. B. da; GRATTAPAGLIA, D.; ANDRADE, A. C. Development and validation of a 26K Axiom® SNP array for Coffea canephora. In: SIMPÓSIO INTERNACIONAL DE GENÉTICA E MELHORAMENTO, 8., 2017, Viçosa, MG. Ômicas: do gene ao fenótipo. [Proceedings...] Viçosa, MG: UFV, 2017.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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17. | | CARNEIRO, F. de A.; MARRACCINI, P.; SILVA JUNIOR, O. B. da; GRATTAPAGLIA, D.; ANDRADE, A. C. Development and validation of a 26K Axiom® SNP array for Coffea canephora. In: SIMPÓSIO INTERNACIONAL DE GENÉTICA E MELHORAMENTO, 8., 2017, Viçosa, MG. Ômicas: do gene ao fenótipo. [Proceedings...] Viçosa, MG: UFV, 2017.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Café. |
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18. | | GRATTAPAGLIA, D.; SILVA JUNIOR, O. B. da; RESENDE, L. V.; SILVA, P. I. T. A five-species 50K Axiom SNP microarray allows high quality genotyping of coffee, cashew, cassava, brazilian pine and eucalyptus. In: PLANT AND ANIMAL GENOME CONFERENCE, 25., 2017, San Diego. [Abstracts...]. San Diego, CA: [s.n.], 2017.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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Registros recuperados : 114 | |
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