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Registro Completo |
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Biblioteca(s): |
Embrapa Pantanal. |
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Data corrente: |
20/08/2003 |
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Data da última atualização: |
27/03/2017 |
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Autoria: |
FOURNIER, D.; BRIDE, J. M.; HOFFMANN, F.; KARCH, F. |
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Afiliação: |
Centre de Recherche d'Antibes, Laboratoire de Biologie des Invertebres, Antibes, France; Department of Zoology and Animal Bioloogy, University of Geneva, Cheone-Bougeries, Geneva, Swirtzerland. |
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Título: |
Acetylcholinesterase two types of modifications confer resistance to insecticide. |
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Ano de publicação: |
1992 |
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Fonte/Imprenta: |
Journal of Biological Chemistry, v.267, n.20, p.14270-14274, 1992. |
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Idioma: |
Inglês |
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Conteúdo: |
Quantitative and qualitative changes in acetylcholinesterase confer resistance to insecticides. We have constructed several Drosophila melanogaster strains producing various amounts of enzyme by P-mediated transformation. Toxicological analysis of these strains demonstrates that resistance to organophosphorus insecticides is correlated with the amount of acetylcholinesterase in the central nervous system. Resistance may also be qualitatively determined. Comparison of the Drosophila acetylcholinesterase gene between a resistant strain caught in the wild and a wild type susceptible strain only revealed one nucleotide transition resulting in the replacement of a phenylalanine by a tyrosine. Flies mutant for acetylcholinesterase and rescued with a minigene mutagenised for this same transition produced an altered enzyme which renders flies resistant to pesticides. |
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Palavras-Chave: |
Fly; Insectecide; Insetecida; Resistance. |
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Thesagro: |
Drosophila Melanogaster; Mosca; Resistência. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01518naa a2200241 a 4500
001 1810850
005 2017-03-27
008 1992 bl --- 0-- u #d
100 1 $aFOURNIER, D.
245 $aAcetylcholinesterase two types of modifications confer resistance to insecticide.
260 $c1992
520 $aQuantitative and qualitative changes in acetylcholinesterase confer resistance to insecticides. We have constructed several Drosophila melanogaster strains producing various amounts of enzyme by P-mediated transformation. Toxicological analysis of these strains demonstrates that resistance to organophosphorus insecticides is correlated with the amount of acetylcholinesterase in the central nervous system. Resistance may also be qualitatively determined. Comparison of the Drosophila acetylcholinesterase gene between a resistant strain caught in the wild and a wild type susceptible strain only revealed one nucleotide transition resulting in the replacement of a phenylalanine by a tyrosine. Flies mutant for acetylcholinesterase and rescued with a minigene mutagenised for this same transition produced an altered enzyme which renders flies resistant to pesticides.
650 $aDrosophila Melanogaster
650 $aMosca
650 $aResistência
653 $aFly
653 $aInsectecide
653 $aInsetecida
653 $aResistance
700 1 $aBRIDE, J. M.
700 1 $aHOFFMANN, F.
700 1 $aKARCH, F.
773 $tJournal of Biological Chemistry$gv.267, n.20, p.14270-14274, 1992.
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Registro original: |
Embrapa Pantanal (CPAP) |
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