Data/hora: 14/06/2024 20:14:30

Biblioteca(s): 	Embrapa Caprinos e Ovinos.	
Data corrente: 	19/10/2004	
Data da última atualização: 	26/07/2023	
Autoria: 	HORIKAWA, S.; TAKAI, T.; TOYOSATO, M.; TAKAHASHI, H.; NODA, M.; KAKIDANI, H.; KUBO, T.; HIROSE, T.; INAYAMA, S.; HAYASHIDA, H.; MIYATA, T.; NUMA, S.	
Título: 	Isolation and structural organization of the human preproenkephalin B gene.	
Ano de publicação: 	1983	
Fonte/Imprenta: 	Nature, v. 306, p. 611-614, Dec. 1983.	
Idioma: 	Inglês	
Conteúdo: 	Abstract: The primary structure of porcine preproenkephalin B has been elucidated by cloning and sequencing cDNA: it contains neoendorphin, dynorphin and leumorphin (containing rimorphin as its amino-terminus). These opioid peptides, each having a leucine-enkephalin structure, act on the kappa-receptor. We have now cloned a human genomic DNA segment containing the preproenkephalin B gene. The structural organization of this gene resembles those of the genes encoding the other opioid peptide precursors, that is, preproenkephalin A and the corticotropin-beta-lipotropin precursor (ACTH-beta-LPH precursor). The primary structure of human preproenkephalin B has been deduced from the gene sequence. The amino acid sequence homology observed between preproenkephalin B and preproenkephalin A, together with the similarity between their gene organizations, suggests that the two genes have been generated from a common ancestor by gene duplication.	
Palavras-Chave: 	Base Sequence; Opioide; Protein precursors; Sequência nucléica.	
Thesagro: 	Clonagem; DNA; Genética.	
Thesaurus Nal: 	Amino acid sequences; Genetics; Molecular cloning.	
Categoria do assunto: 	G Melhoramento Genético	
Registro original: 	Embrapa Caprinos e Ovinos (CNPC)	
Exemplares: 	CNPC - (17251-1) - ADD - AP - DD -  -  -  - DIS